Herpes Simplex Virus Type 2 Seroprevalence Among Different National Populations of Middle East and North African Men

Dargham, Soha R.; Nasrallah, Gheyath K.; Al-Absi, Enas S.; Mohammed, Layla; Aldisi, Rana; Nofal, Mariam Y.; Abu‐Raddad, Laith J.

doi:10.1097/olq.0000000000000791

Cited by 24 publications

(31 citation statements)

References 23 publications

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“…We provided a comprehensive assessment of C trachomatis epidemiology in the Middle East and north Africa. 2,3 Unexpectedly, given this region's sexually conservative norms and low observed levels of several viral STIs, 10,11,[187][188][189] C trachomatis current infection prevalence was 3% in the population at large, similar to WHO prevalence estimates for this region of about 3% in 2012 3 and about 3•5% in 2016. 190 The prevalence was also in line with WHO estimates for the Western Pacific region (about 4%) and European region (about 3%), 190 where broad C trachomatis control programmes, including opportunistic testing, are stand ard in some highincome countries, [191][192][193] but higher than that for Southeast Asia region (about 1•5%) and lower than that for the African region (about 5%) and the region of the Americas (about 5•5%).…”

Section: Discussionsupporting

confidence: 61%

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Smolak

Chemaitelly

Hermez

et al. 2019

The Lancet Global Health

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Background The epidemiology of Chlamydia trachomatis in the Middle East and north Africa is poorly understood. We aimed to provide a comprehensive epidemiological assessment of C trachomatis infection in the Middle East and north Africa. Methods We did a systematic review of C trachomatis infection as well as a meta-analysis and meta-regression of C trachomatis prevalence. We searched PubMed and Embase, as well as regional and national databases up to March 13, 2019, using broad search terms with no language or year restrictions. Any document or report including biological measures for C trachomatis prevalence or incidence was eligible for inclusion. We extracted all measures of current (genital or rectal), recent, and ever infection with C trachomatis. We estimated pooled average prevalence in different populations using random-effects meta-analysis. Factors associated with prevalence and sources of betweenstudy heterogeneity were determined using meta-regression. Findings We identified a total of 1531 citations, of which 255 reports contributed to 552 C trachomatis prevalence measures from 20 countries. No incidence measures were identified. Pooled prevalence of current genital infection was 3•0% (95% CI 2•3-3•8) in general populations, 2•8% (1•0-5•2) in intermediate-risk populations, 13•2% (7•2-20•7) in female sex workers, 11•3% (9•0-13•7) in infertility clinic attendees, 12•4% (7•9-17•7) in women with miscarriage, 12•4% (9•4-15•7) in symptomatic women, and 17•4% (12•5-22•8) in symptomatic men. Pooled prevalence of current rectal infection was 7•7% (4•2-12•0) in men who have sex with men. Substantial between-study heterogeneity was found. Multivariable meta-regression explained 29•0% of variation. Population type was most strongly associated with prevalence. Additional associations were found with assay type, sample size, country, and sex, but not with sampling methodology or response rate (about 90% of studies used convenience sampling and >75% had unclear response rate). There was no evidence for temporal variation in prevalence between 1982 and 2018. Interpretation C trachomatis prevalence in the Middle East and north Africa is similar to other regions, but higher than expected given its sexually conservative norms. High prevalence in infertility clinic attendees and in women with miscarriage suggests a potential role for C trachomatis in poor reproductive health outcomes in this region.

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Section: Discussionsupporting

confidence: 61%

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Smolak

Chemaitelly

Hermez

et al. 2019

The Lancet Global Health

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“…For the control group, we utilized samples from healthy blood donors collected before 2019 and used in previous studies ( Nasrallah et al, 2017 , Smatti et al, 2017 , Humphrey et al, 2019 , Al-Qahtani et al, 2016 , Dargham et al, 2018 , Nasrallah et al, 2018 , Smatti et al, 2020 , Al Kahlout et al, 2019 ). The healthy blood donors had a median age of 36.0 (30.3-45.0) with 82.9% males and 8.6% females.…”

Section: Methodsmentioning

confidence: 99%

“…The healthy blood donors had a median age of 36.0 (30.3-45.0) with 82.9% males and 8.6% females. Details about the collection, transport, and storage methods of the control samples were described elsewhere ( Nasrallah et al, 2017 , Smatti et al, 2017 , Humphrey et al, 2019 , Al-Qahtani et al, 2016 , Dargham et al, 2018 , Nasrallah et al, 2018 , Smatti et al, 2020 , Al Kahlout et al, 2019 ). The control group included samples that are seropositive for various viruses, including all other human coronaviruses (HCoV).…”

Section: Methodsmentioning

confidence: 99%

Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies

Yassine¹,

Al-Jighefee²,

Al-Sadeq³

et al. 2021

International Journal of Infectious Diseases

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Highlights Performances of five commercial ELISA (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG was evaluated. Samples used in this study are from diverse national background and the negative group contains samples that are seropositive for all other HCoV. All assays showed low sensitivity during the early stages (≤7 from symptom onset); however, it was greatly improved overtime. Lionex showed the highest specificity (98.6%), followed by EDI and Dia.Pro (97.1%,), NovaTec (85.7%), and AnshLabs (75.7%). Lionex, which measures antibodies to the S1 protein, demonstrated the best performance and doesn’t cross-react with any other HCoV.

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“…We recently provided measures of HSV-1 seroprevalence (18) and HSV-2 seroprevalence (19) in 10 national Middle Eastern and North African populations currently living in Qatar, including Qatari citizens. One of the findings was an unexpectedly low seroprevalence of HSV-1 in Pakistanis, suggesting that HSV-1 seroprevalence in populations from the Indian subcontinent could be lower than global levels; the reasons for this low seroprevalence are still not known.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Herpes simplex virus types 1 and 2 in Indian and Filipino migrant populations in Qatar: a cross-sectional survey

Nasrallah¹,

Dargham²,

Harfouche³

et al. 2020

East Mediterr Health J

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Background: The epidemiology of herpes simplex virus infections is of growing interest but information on its seroprevalence in many countries is scarce. Aims: This study aimed to measure the seroprevalence of herpes simplex virus type 1 and type 2 in Filipino and Indian men living in Qatar. Methods: Blood serum specimens were collected from male blood donors aged ≥ 18 years in Qatar from 2013 to 2016. HerpeSelect® 1/2 and Euroline-WB assays were used to measure antibodies to herpes simplex virus types 1 and 2 in 120 Filipino and 325 Indian men. Results: The seroprevalence of herpes simplex virus-1 was 84.9% (95% confidence interval (CI): 78.4-90.0%) in Filipino men and 48.3% (95% CI: 43.6-53.0%) in Indian men. The seroprevalence of herpes simplex virus-2 was 8.3% (95% CI: 4.6-13.7%) in Filipinos and 3.7% (95% CI: 2.2-5.9%) in Indians. The seroprevalence of herpes simplex virus types 1 and 2 increased with age, but this trend was only statistically significant in Indian men (P = 0.013 and P = 0.011 respectively). Conclusions: The seroprevalence rates of herpes simplex virus-2 in Filipino and Indian men living in Qatar were similar to those found in the Philippines and India. However, the seroprevalence of herpes simplex virus-1 in Indians, while similar to that found in India, was substantially lower than that of other countries in Asia and developing countries worldwide, which needs further investigation.

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Herpes Simplex Virus Type 2 Seroprevalence Among Different National Populations of Middle East and North African Men

Abstract: Herpes simplex virus type 2 seroprevalence among male blood donors from different Middle East and North Africa nationalities was in the range of few percentage points.Supplemental digital content is available in the text.

Cited by 24 publications

References 23 publications

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Epidemiology of Chlamydia trachomatis in the Middle East and north Africa: a systematic review, meta-analysis, and meta-regression

Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies

Seroprevalence of Herpes simplex virus types 1 and 2 in Indian and Filipino migrant populations in Qatar: a cross-sectional survey

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