Herpes Simplex Virus Type 2 Antibody in Patients Attending Antenatal or STD Clinics

Cunningham, Anthony L.; Lee, Francis K.; Ho, David; Field, Peter R.; Law, Carmella; Packham, D. R.; McCrossin, Ian; Sjögren‐Jansson, Eva; Jeansson, Stig; Nahmias, André J.

doi:10.1097/00006254-199401000-00004

Cited by 7 publications

(10 citation statements)

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“…HSV-2 infections have increased in some communities 20 23 but appear relatively static in western Sydney. A study in 1986 with 229 consecutive specimens from antenatal patients using identical laboratory methods showed a prevalence of 14.5%, 11 while the current study showed a prevalence of 12.5%.…”

Section: Discussioncontrasting

confidence: 57%

Neonatal herpes prevention: a minor public health problem in some communities

Mindel

Taylor²,

Tideman³

et al. 2000

Sexually Transmitted Infections

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Background: Neonatal herpes is a condition with high morbidity and mortality. The greatest risk occurs when the mother acquires herpes simplex virus (HSV) towards the end of pregnancy. A study from Seattle has suggested that the risk of acquisition of HSV during pregnancy was 3.7%. In Australia, HSV-2 infection is less common in pregnant women than in the United States. Consequently we conducted a study to establish HSV seroprevalence and the rate of HSV seroconversion in this population. Methods: The study was conducted at Westmead Hospital, Sydney, between June 1995 and April 1998. Women completed a questionnaire covering risk factors for the acquisition of genital herpes. A serum sample during pregnancy and a specimen of cord blood were obtained and tested for antibodies to HSV-2 using a type specific indirect enzyme linked immunosorbent assay (ELISA). Equivocal results were resolved by western blot. A subset of the paired sera was tested for antibodies to HSV-1. The data were analysed using SPSS. Results: 326 of the 2616 (12.5%) women were HSV-2 seropositive. Three women (0.15%) acquired HSV-2 infection during pregnancy. None of the three babies of these mothers developed neonatal herpes. 416 maternal cord pairs were tested for HSV-1 antibodies and 330 (79.3%) were positive. No HSV-1 seroconversions occurred. Conclusions: In this population, HSV acquisition was uncommon (0.34% per year) and neonatal herpes was rare. A cost eVective analysis suggested that type specific serology to screen pregnant women and their partners in low prevalence communities was not cost eVective. (Sex Transm Inf 2000;76:287-291)

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Section: Discussioncontrasting

confidence: 57%

Neonatal herpes prevention: a minor public health problem in some communities

Mindel

Taylor²,

Tideman³

et al. 2000

Sexually Transmitted Infections

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“…Such studies have found a wide range of seroprevalence of HSV-2, which varies according to the populations studied, from 11.3% in women attending antenatal clinics to over 70% in commercial sex workers. [6][7][8] Various population-based studies conducted in developed and developing countries have reported HSV-2 seroprevalence in the range of 5.6-42.2%. [9][10][11][12] However, very few populationbased studies on the seroprevalence of HSV-2 have been carried out in India.…”

mentioning

confidence: 99%

Community-based study on seroprevalence of herpes simplex virus type 2 infection in New Delhi

Chawla¹,

Bhalla²,

Singh³

et al. 2008

Indian J Med Microbiol

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“…Because it is almost exclusively sexually transmitted and leads to the production of lifelong antibodies and because seropositivity is associated with higher risk sexual behavior in selected populations [6,7], it has been suggested that HSV-2 antibody could be used as a biologic marker of risk behavior [8]. HSV-2 is also of interest in subSaharan Africa for other reasons: It increases the risk of HIV transmission and acquisition [9], and it is increasingly recognized that its role in the etiology of genital ulceration in African populations has been underestimated [10].…”

mentioning

confidence: 99%

Antibody to Herpes Simplex Virus Type 2 as a Marker of Sexual Risk Behavior in Rural Tanzania

Obasi¹,

Mosha²,

Quigley³

et al. 1999

J INFECT DIS

155

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A serosurvey was conducted in a random sample of 259 women and 231 men in 12 rural communities in Mwanza Region, Tanzania, using a type-specific ELISA for Herpes simplex virus type 2 (HSV-2) infection. Seroprevalence rose steeply with age to approximately 75% in women >=25 years old and 60% in men >=30. After adjusting for age and residence, HSV-2 prevalence was higher in women who were married, in a polygamous marriage, Treponema pallidum hemagglutination assay (TPHA)-positive, had more lifetime sex partners, or who had not traveled. Prevalence was higher in men who were married, had lived elsewhere, had more lifetime partners, had used condoms, or were TPHA-positive. HSV-2 infection was significantly associated with recent history of genital ulcer. The association between HSV-2 infection and lifetime sex partners was strongest in those <25 years old in both sexes. This association supports the use of HSV-2 serology as a marker of risk behavior in this population, particularly among young people.

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Herpes Simplex Virus Type 2 Antibody in Patients Attending Antenatal or STD Clinics

Cited by 7 publications

References 0 publications

Neonatal herpes prevention: a minor public health problem in some communities

Neonatal herpes prevention: a minor public health problem in some communities

Community-based study on seroprevalence of herpes simplex virus type 2 infection in New Delhi

Antibody to Herpes Simplex Virus Type 2 as a Marker of Sexual Risk Behavior in Rural Tanzania

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