Herpes simplex virus type 2 or human herpesvirus 8 infection and prostate cancer risk: A meta-analysis

Abstract

Abstract. Prostate cancer is the second most frequently diagnosed type of cancer and the sixth leading cause of cancer mortality among males worldwide. The aim of this study was to investigate the association between the infection by herpes simplex virus type 2 (HSV-2) or human herpesvirus 8 (HHV-8) and the risk of prostate cancer. A systematic literature search was performed using PubMed, Cochrane Library, Web of Science, Scopus, CNKI and CBM. The association of HSV-2 or HHV-8 infection with the risk of prostate cancer was separately assessed. Estimates of the odds ratio (OR) with 95% confidence interval (CI) were pooled by the fixed-or random-effects model. A total of 11 articles with 2,996 cases and 3,875 controls were included in this meta-analysis. HSV-2 infection was associated with increased prostate cancer risk (OR=1.209; 95% CI, 1.003-1.456). Results of the stratified analysis suggested that such an association existed among participants from North and South America (OR=1.226; 95% CI, 1.000-1.503). No significant correlation was observed in the HHV-8 group (OR=1.106; 95% CI, 0.765-1.598). Further investigations and large-sample studies are required to elucidate the possible mechanism underlying viral carcinogenesis and the association between herpes virus infection and the risk of prostate cancer.

Prospective study of human herpesvirus type 8 serostatus and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

“…In one of the first studies to investigate HHV-8 infection and PCa, Hoffman and colleagues (9) observed a positive association between HHV-8 seropositivity and PCa in a series of case-control studies, most notably one conducted among Afro-Caribbean men from Tobago (Table 1). Subsequent studies, however, have observed null and sometimes even suggestive inverse findings between HHV-8 seropositivity and PCa (10-15), particularly those published before the execution of the present study (10-12). Therefore, to further inform the possible relation between HHV-8 infection and PCa, and to investigate the reproducibility of previous suggestive inverse findings, we conducted a case-control study sampled from the placebo arm of the Prostate Cancer Prevention Trial (PCPT).…”

Increased Expression of Herpes Virus-Encoded hsv1-miR-H18 and hsv2-miR-H9-5p in Cancer-Containing Prostate Tissue Compared to That in Benign Prostate Hyperplasia Tissue

“…Several epidemiologic studies have suggested possible associations between STIs and CaP [ 17 - 19 ], but the data are inconsistent. A recent meta-analysis suggested that herpes virus type 2 infection is associated with an increased risk of CaP (odds ratio, 1.209; 95% confidence interval [CI], 1.003–1.456) [ 20 ]. However, another meta-analysis showed that men who reported never having had an STI were at increased risk for CaP (summary relative risk [SRR], 1.49; 95% CI, 1.19–1.92), and that men with gonorrheal infection also showed an increased risk of CaP (SRR, 1.20; 95% CI, 1.05–1.37) [ 6 ].…”

Virus encoded circulatory miRNAs for early detection of prostate cancer

“…However, this is still contradictory since other epidemiological studies could not find same association [ 23 – 25 ]. Therefore, an elaborate and comprehensive demonstration of the association between herpes virus infection and prostate cancer risk is of significance [ 24 ]. Further investigations and large-sample studies are required to and the relationship between herpes virus infection and prostate cancer risk.…”