Herpes Simplex Virus Reactivation and Disease during Treatment for Childhood Acute Lymphoblastic Leukemia

Lauten, Melchior; Güttel, Christian; Härtel, Christoph; Erdlenbruch, Bernhard

doi:10.1055/s-0033-1354387

Cited by 5 publications

(6 citation statements)

References 12 publications

(13 reference statements)

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“…The viral replication and slight inflammatory cell infiltration in the nervous tissues observed on day ten post-infection suggested that the virus was transmitted to target tissues, likely through axial retrograde transport along peripheral nerves [ 37 ]. In clinical observations of humans infected by HSV1, vesicular lesions in the oral skin and other tissues, where the viral genome can be detected, are associated with histopathological changes [ 52 ]. These findings indicated a similarity of the HSV1 infectious process in macaques and humans.…”

Section: Discussionmentioning

confidence: 99%

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features

Fan

Cai

et al. 2017

Viruses

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As one of the major pathogens for human herpetic diseases, herpes simplex virus type 1 (HSV1) causes herpes labialis, genital herpes and herpetic encephalitis. Our aim here was to investigate the infectious process of HSV1 in rhesus macaques and the pathological features induced during this infection. Clinical symptoms that manifested in the rhesus macaque during HSV1 infection included vesicular lesions and their pathological features. Viral distribution in the nervous tissues and associated pathologic changes indicated the typical systematic pathological processes associated with viral distribution of HSV1. Interestingly, vesicular lesions recurred in oral skin or in mucosa associated with virus shedding in macaques within four to five months post-infection, and viral latency-associated transcript (LAT) mRNA was found in the trigeminal ganglia (TG) on day 365 post-infection. Neutralization testing and enzyme-linked immunospot (ELISpot) detection of specific T cell responses confirmed the specific immunity induced by HSV1 infection. Thus, rhesus macaques could serve as an infectious model for HSV1 due to their typical clinical symptoms and the pathological recurrence associated with viral latency in nervous tissues.

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Section: Discussionmentioning

confidence: 99%

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features

Fan

Cai

et al. 2017

Viruses

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“…Five children (four boys, one girl; median age 5 years, range, 1‐12 years) with systemic HSV infection (two patients with HSV type 1, unspecified in three patients) were reported (Table 1). 31,32 All patients suffered from ALL. All patients had a severe clinical course including hepatitis, pneumonitis, or encephalitis.…”

Section: Resultsmentioning

confidence: 99%

Systemic viral infection in children receiving chemotherapy for acute leukemia

Buus-Gehrig

Bochennek

Hennies

et al. 2020

Pediatric Blood & Cancer

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Systemic viral diseases frequently occur in allogeneic hematopoietic stem cell transplantation, but data in children receiving chemotherapy for acute leukemia are scarce. We therefore collected and analyzed the published data on symptomatic infection from cytomegalovirus, herpes simplex virus, varicella zoster virus, parvovirus B19, or adenovirus in pediatric acute leukemia. Reports on 68 children were identified, of whom 16 patients have died from the infection. Further studies have to (1) evaluate the true incidence of these infections in pediatric acute leukemia, (2) their impact on outcome, and (3) whether a subpopulation of patients could benefit from screening and prophylactic strategies. K E Y W O R D S acute leukemia, adenovirus, child, cytomegalovirus, herpes simplex virus, parvovirus B19, systemic viral disease, varicella zoster virus We performed a MEDLINE (including MEDLINE In Process) search to identify relevant English-language articles indexed from January 1, 2000, up to December 31, 2019. The search included a combination of indexed terms and free text terms (child OR adolescent OR pediatr*); (cancer OR malignancy OR leukemia); (parvovirus OR b19)/(adenovirus)/(varicella or VZV)/(cytomegalovirus or CMV)/(herpes simplex virus or HSV). The hits were screened manually by two of the authors (CBG and TL). Only case reports and case series about systemic infections or studies on the prevalence of viremia with CMV, HSV, VZV, PVB19, and ADV, respectively, occurring in children

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“…El segundo grupo viral importante son los virus herpes, estos son los causantes de episodios febriles en hasta 10% de los pacientes con leucemia y puede estar presente hasta en el 50% de los casos de mucositis por quimioterapia, especialmente en la población pediátrica. La presentación clínica más relevante es la meningoencefalitis (115,131). Esta infección no es exclusiva de los VHS tipo 1 ya que VHS-2 han sido también descritos asociados a ciclos de BEP (Bleomicina, fosfato de etopósido y cisplatino) en reporte de casos incluyendo clínica atípica con necrosis retiniana aguda bilateral (131,132).…”

Section: Asociadas Al Tratamiento Antineoplásicounclassified

“…Esta infección no es exclusiva de los VHS tipo 1 ya que VHS-2 han sido también descritos asociados a ciclos de BEP (Bleomicina, fosfato de etopósido y cisplatino) en reporte de casos incluyendo clínica atípica con necrosis retiniana aguda bilateral (131,132). Estos pacientes se han reportado en TOS y TPH con hallazgos de LCR y tratamiento similar al establecido en otras poblaciones con Aciclovir como principal agente farmacológico (115,132).…”

Section: Asociadas Al Tratamiento Antineoplásicounclassified

Fístula esófago-espondilorraquídea en paciente tratado con radioterapia y quimioterapia

Cordero-Jiménez

Tenor-Serrano

Muñoz-Palza

et al. 2012

Acta Otorrinolaringológica Española

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Herpes Simplex Virus Reactivation and Disease during Treatment for Childhood Acute Lymphoblastic Leukemia

Cited by 5 publications

References 12 publications

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features

The Characteristics of Herpes Simplex Virus Type 1 Infection in Rhesus Macaques and the Associated Pathological Features

Systemic viral infection in children receiving chemotherapy for acute leukemia

Fístula esófago-espondilorraquídea en paciente tratado con radioterapia y quimioterapia

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