Herpes simplex virus-infected squamous cell carcinoma: a case report

Brown, Sarah H.; States, Vanessa; Afghan, Abaseen Khan; Satyanarayana, Gowri

doi:10.1186/s12879-021-06995-8

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…Cancer cells are vulnerable to superimposed viral infections, including HSV-1, which likely led to the findings in this case. 127 HSV-2 causes most genital herpes and has been epidemiologically associated with cervical cancer. It has been found in prostate cancer cells.…”

Section: Human Oncogenic Dna Virusesmentioning

confidence: 99%

The Role of DNA Viruses in Human Cancer

2023

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This review discusses the possible involvement of infections-associated cancers in humans, with virus infections contributing 15% to 20% of total cancer cases in humans. DNA virus encoded proteins interact with host cellular signaling pathways and control proliferation, cell death and genomic integrity viral oncoproteins are known to bind cellular Deubiquitinates (DUBs) such as cyclindromatosis tumor suppressor, ubiquitin-specific proteases 7, 11, 15 and 20, and A-20 to improve their intracellular stability and cellular signaling pathways and finally transformation. Human papillomaviruses (cervical carcinoma, oral cancer and laryngeal cancer); human polyomaviruses (mesotheliomas, brain tumors); Epstein-Barr virus (B-cell lymphoproliferative diseases and nasopharyngeal carcinoma); Kaposi’s Sarcoma Herpesvirus (Kaposi’s Sarcoma and primary effusion lymphomas); hepatitis B (hepatocellular carcinoma (HCC)) cause up to 20% of malignancies around the world.

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Section: Human Oncogenic Dna Virusesmentioning

confidence: 99%

The Role of DNA Viruses in Human Cancer

2023

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“…HSV strains 1 and 5 were identified in six of 30 samples. HSV was previously reported in samples from HNSCC and OSCC patients and its association with the progression of cancer was claimed [50][51][52] Enterovirus has been associated with malignant glioma 53 . SV was reported in samples of osteosarcoma and prostate cancer [54][55][56] .…”

Section: Discussionmentioning

confidence: 97%

The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants and fusions

Frenkel-Morgenstern,

Bhattacharya,

Yaniv

et al. 2024

Preprint

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Circulating cell-free DNA (cfDNA) has been widely used as a prognostic marker for different cancers. In this study, we used cfDNA from oral squamous cell carcinoma (OSCC) patients to study various correlation factors that could improve the disease early-stage diagnostics and/or prognosis. We found that OSCC patient cfDNA concentration can serve as an indicator of tumor stage, malignancy, and survival prognosis. Deep genome sequencing of cfDNA revealed genomic alterations, such as copy number variations, fusion gene identification, and viral integrations. Copy number variation analysis suggested correlation with amplification and deletion in chromosome 1 at loci 1q, 2q, 3p, 3q and 8q22. Moreover, at these loci, amplification of TP53, PIK3CA and other genes related to keratinization in OSCC patients were observed. In addition, we identified the novel fusion gene, TRMO-TRNT1 ‘chimera’, in seven high-grade tumor samples. The parental genes of this chimera, TRMO and TRNT1, are known to play roles in tRNA modification and DNA repair, respectively. Therefore, our study indicates that liquid biopsy may thus serve as a sensitive tool to study OSCC patient genomic alterations by exploring cfDNA circulating in the plasma, by means of an easy-to-use blood test. Finally, we detected integrations of human papilloma virus, simian virus, and enterovirus in the OSCC samples, that may point to the origins of OSCC.

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“…HSV strains 1 and 5 were identified in six of 30 samples. HSV was previously reported in samples from HNSCC and OSCC patients and its association with the progression of cancer was claimed 50–52 Enterovirus has been associated with malignant glioma 53 . SV was reported in samples of osteosarcoma and prostate cancer 54–56 .…”

Section: Discussionmentioning

confidence: 99%

“…HSV strains 1 and 5 were identified in 6 of 30 samples. HSV was previously reported in samples of HNSCC and OSCC patients and its association with the progression of cancer was claimed (Mosmann et al ., 2019; Wołaçewicz et al ., 2020; Brown et al ., 2022). Enterovirus has been associated with malignant glioma (Zhang et al ., 2020).…”

Section: Discussionmentioning

confidence: 99%

The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants, fusions and oncoviruses

Bhattacharya,

Yaniv,

Yosefof

et al. 2023

Preprint

View full text Add to dashboard Cite

Circulating cell-free DNA (cfDNA) has been widely used as a prognostic marker of different cancers. In this study, we used cfDNA from oral squamous cell carcinoma (OSCC) patients to study various correlation factors that could improve early-stage diagnostics and prognosis. We found that OSCC patient cfDNA concentration can serve as an indicator of tumor stage, malignancy, and survival prognosis. Deep genome sequencing of cfDNA revealed genomic alterations, such as copy number variation, fusion gene identification, and viral integration. Copy number variation analysis suggested correlation with amplification and deletions in chromosome 1 at loci 1q, 2q, 3p, 3q and 8q22. Moreover, at these loci, amplification ofTP53, PIK3CAand other genes related to keratinization in relapsed OSCC was observed. In addition, we identified a novel fusion gene,TRMO-TRNT1, in seven high-grade tumor samples. The parent genes of this chimera,TRMOandTRNT1, are known to play roles in tRNA modification and DNA repair. Liquid biopsy may thus serve as a sensitive tool to study OSCC patient genomic alterations by addressing cfDNA circulating in the plasma, using an easy-to-use blood test. Finally, we detected integrations of human papilloma virus, simian virus and enterovirus that may point to the origins of OSCC.

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Herpes simplex virus-infected squamous cell carcinoma: a case report

Cited by 8 publications

References 12 publications

The Role of DNA Viruses in Human Cancer

The Role of DNA Viruses in Human Cancer

The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants and fusions

The applications of circulating cell-free DNA for oral squamous cell carcinoma patients as non-invasive diagnostics of structural variants, fusions and oncoviruses

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