Herpes Simplex Virus Hepatitis in Infants: Clinical Outcomes and Correlates of Disease Severity

Whole Blood Polymerase Chain Reaction in a Neonate with Disseminated Herpes Simplex Virus Infection and Liver Failure

“…Of note, in this series seven of the infants were diagnosed with infection due to HSV-1 and four infants with HSV-2, highlighting the fact that HSV-1 can cause genital infection in adults and severe disease in the neonate. A second case series of 15 infants with HSV hepatitis suggested the following predictors of more severe disease: positive PCR, lack of skin lesions, and degree of severity of coagulopathy, thrombocytopenia, and cholestasis 9. There have been several case reports of successful treatment of fulminant hepatic failure from neonatal HSV with liver transplantation, underscoring the value of early consultation with a liver transplant center 10…”

Neonatal acute liver failure: a diagnosis challenge

“…Post-transplant course may be favorable, even in children with active viral load, and requires long-term treatment with acyclovir. 7,8 Enteroviruses are ribonucleic acid (RNA) viruses of the Picornaviridae family and, even though they cause a mild disease in adults, they may be the cause of NALF. A maternal history of recent respiratory disease or diarrhea must give rise to the suspicion of this etiology.…”

Insuficiencia hepática aguda neonatal: un desafío diagnóstico

“…La evolución postrasplante puede ser favorable, aun en niños con viremia activa, y requiere tratamiento prolongado con aciclovir. 7,8 Los enterovirus son virus de ácido ribonucleico (ARn) de la familia Picornaviridae y, aunque originan una enfermedad leve en el adulto, pueden ser causa de IHAn. El antecedente materno de una enfermedad diarreica o respiratoria reciente nos debe hacer sospechar esta etiología.…”