2016
DOI: 10.1099/jgv.0.000341
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Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection

Abstract: Herpes simplex virus (HSV) was originally implicated in the aetiology of cervical cancer, and although high-risk human papillomavirus (HPV) is now the accepted causative agent, the epidemiological link between HSV and HPV-associated cancers persists. The annexin A2 heterotetramer (A2t) has been shown to mediate infectious HPV type 16 (HPV16) uptake by human keratinocytes, and secretory leukocyte protease inhibitor (SLPI), an endogenous A2t ligand, inhibits HPV16 uptake and infection. Interestingly, HSV infecti… Show more

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Cited by 18 publications
(19 citation statements)
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“…17,18 Conversely, reductions in the amount of SLPI secreted by epithelial cells was shown to promote HPV16 infection through annexin A2 in vitro . 19 …”
Section: Introductionmentioning
confidence: 99%
“…17,18 Conversely, reductions in the amount of SLPI secreted by epithelial cells was shown to promote HPV16 infection through annexin A2 in vitro . 19 …”
Section: Introductionmentioning
confidence: 99%
“…Cofactor action of Herpesviruses in HPV-induced tumor diseases is connected not only with their influence on HPV oncoproteins Е6 and та Е7 [13] but inflammation [14] and immune suppression development [15]. Genital herpes is one of the most wide-spread common disease with sexual way of transmission, and differs from other disease of this group by its life carriage.…”
Section: Results and Discussion In Patients Serum With Cu Hpvi Withomentioning
confidence: 99%
“…Do kraja 1970-ih smatralo se da je etiološki agens u cervikalnom i oralnom karcinomu Herpes Simplex virus. Iako je visokorizični HPV sada identifikovan kao uzrok karcinoma grlića materice, HSV se smatra važnim kofaktorom u njegovoj pojavi 24 . Svetska prevalencaija OSCC-a, koja je bila pozitivna za HSV-1, bila je oko 15%; najveća prevalenca ija od 55% zabeležena je u Velikoj Britaniji.…”
Section: Herpes Simplex Virus (Hsv)unclassified
“…Ispitanici pozitivni na HPV infekciju koji su takođe seropozitivni na HSV -1 imaju dvostruko veći rizik od razvoja karcinoma skvamoznih ćelija u poređenju sa HSV -1-seronegativnim osobama sa sličnom izloženošću HPV-u. Ovi nalazi pokazuju da HSV i HPV mogu delovati sinergistički u razvoju karcinoma 24 .…”
Section: Herpes Simplex Virus (Hsv)unclassified