Herpes Simplex Virus

Cole, Shannon

doi:10.1016/j.cnur.2020.05.004

Cited by 37 publications

(39 citation statements)

References 19 publications

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“…Herpesviruses are enveloped viruses that are divided into three subfamilies: alphaherpesvirinae, betaherpesvirinae, and gammaherpesvirinae ( Figure 2 ) [ 148 ]. The human alphaherpesvirinae subfamily is composed of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), as well as varicella-zoster virus (VZV) [ 149 , 150 ]. The human betaherpesvirinae subfamily contains cytomegalovirus (HCMV), human herpesvirus 6 (HHV-6), and human herpesvirus 7 (HHV-7), while human herpes virus 4 and 8, which correspond to Epstein-Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), respectively, belong to the gammaherpesvirinae subfamily [ 148 ].…”

Section: Modulation Of Neutral Lipid Metabolism By Double-stranded Dn...mentioning

confidence: 99%

Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections

Farías

Diethelm‐Varela

Navarro

et al. 2022

Cells

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Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and cholesterol esters that are coated by a phospholipid monolayer and associated proteins. LDs are known to play important roles in the storage and availability of lipids in the cell and to serve as a source of energy reserve for the cell. However, these structures have also been related to oxidative stress, reticular stress responses, and reduced antigen presentation to T cells. Importantly, LDs are also known to modulate viral infection by participating in virus replication and assembly. Here, we review and discuss the interplay between neutral lipid metabolism and LDs in the replication cycle of different DNA viruses, identifying potentially new molecular targets for the treatment of viral infections.

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Section: Modulation Of Neutral Lipid Metabolism By Double-stranded Dn...mentioning

confidence: 99%

Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections

Farías

Diethelm‐Varela

Navarro

et al. 2022

Cells

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“…Herpes simplex virus (HSV) belongs to the Herpesviridae family and the Alphaherpesvirinae subfamily [1]. HSV mainly afects the skin and mucosal membranes [2]. Tere are two types of HSV: type 1 (HSV-1), which is transmitted primarily by oral-to-oral contact and commonly causes herpes labialis (also known as orofacial herpes, cold sores, or fever blisters), and type 2 (HSV-2), which is predominantly transmitted sexually (it is considered a Sexually Transmitted Infection) and constitutes the leading cause of genital lesions [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…HSV mainly afects the skin and mucosal membranes [2]. Tere are two types of HSV: type 1 (HSV-1), which is transmitted primarily by oral-to-oral contact and commonly causes herpes labialis (also known as orofacial herpes, cold sores, or fever blisters), and type 2 (HSV-2), which is predominantly transmitted sexually (it is considered a Sexually Transmitted Infection) and constitutes the leading cause of genital lesions [2][3][4][5]. In exceptional cases, HSV-1 could be responsible for genital herpes and HSV-2 could cause herpes labialis [6].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study

Kituashvili

Kvirkvelia

Galdava

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Background. Previous in vitro and in vivo studies indicated that walnut extract has a therapeutic effect on herpes simplex infections. This study aimed to evaluate the efficacy and tolerance of Lazolex® Gel (Iveriapharma, Tbilisi, Georgia), an emollient gel to treat mucocutaneous lesions caused by herpes simplex virus. Methods. A single-center, single-arm, open-label, phase II clinical trial was conducted with 30 patients divided into two groups: 15 patients with herpes simplex virus type 1 (HSV-1) infections and 15 with herpes simplex virus type 2 (HSV-2). All received topical treatment with Lazolex® Gel four times a day for 10 days. The efficacy and tolerance of the treatment were evaluated on day 10 and day 20 of the study. Recurrence rates were also evaluated both prior to treatment with Lazolex® and over a 4-year follow-up period subsequent to treatment. Results. The median effective time to resolution of symptoms (itching, burning, and pain) was 1.97 days in the HSV-1 group and 3.11 days in the HSV-2 group. The median effective time for vesicles and erosion to disappear was 3.64 days in the HSV-1 group and 3.88 days for the HSV-2 group. Finally, the median effective time for inflammatory signs to disappear was 5.70 and 4.32 days, respectively. Following treatment with Lazolex® Gel, the frequency of outbreaks decreased from a median of 2.00 and 1.00 times per year in the HSV-1 and HSV-2 cohorts to 0.25 and 0.00 ( p = 0.001 and p = 0.003 ), respectively. Conclusions. Topical treatment with Lazolex® Gel applied to lesions four times a day for 10 days was shown to be effective and safe in the treatment of herpes simplex mucocutaneous infections and dramatically reduced the rate of recurrence. Clinical trial was approved by Drug Agency of Ministry of Labour, Health and Social Affairs of Georgia, registration # DA Nº CT-000032, date of approval 01.10.2007.

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“…Although the evidence is inconclusive, MG and TV infection in pregnancy have also been associated with preterm birth [6]. Neonates can become infected with HSV at birth from an infected mother, with potential involvement of the central nervous system and fatal consequences [7]. Both CT and NG can cause irreparable damage to the fallopian tubes, leading to infertility in women [8], and a possible role of these organisms in the reduction of sperm quality and fertility in males has been suggested [9].…”

Section: Introductionmentioning

confidence: 99%

Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections

Caruso

Giammanco

Virruso

et al. 2021

IJERPH

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Sexually transmitted infections (STIs) continue to exert a considerable public health and social burden globally, particularly for developing countries. Due to the high prevalence of asymptomatic infections and the limitations of symptom-based (syndromic) diagnosis, confirmation of infection using laboratory tools is essential to choose the most appropriate course of treatment and to screen at-risk groups. Numerous laboratory tests and platforms have been developed for gonorrhea, chlamydia, syphilis, trichomoniasis, genital mycoplasmas, herpesviruses, and human papillomavirus. Point-of-care testing is now a possibility, and microfluidic and high-throughput omics technologies promise to revolutionize the diagnosis of STIs. The scope of this paper is to provide an updated overview of the current laboratory diagnostic tools for these infections, highlighting their advantages, limitations, and point-of-care adaptability. The diagnostic applicability of the latest molecular and biochemical approaches is also discussed.

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Herpes Simplex Virus

Cited by 37 publications

References 19 publications

Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections

Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections

Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study

Current and Future Trends in the Laboratory Diagnosis of Sexually Transmitted Infections

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