“…In our review of 40 cases of postoperative neurosurgical patients with HSV diagnosis following craniotomy, 12 (30%) patients died and 1 had unreported outcome due to hospital transfer. [1][2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26,[30][31][32][33][34][35][36] Fever, headache, and altered mental status were common presenting symptoms and started anywhere from POD 1 to POD 90, with a majority occurring in a delayed fashion between PODs 7 and 12. 1-4, 6-24, 26, 30-36 Surgical site varied and does not alone explain potential reactivation of HSV, although it is unknown how many of these patients received perioperative steroids.…”