Herpes simplex induced necrotizing tonsillitis in an immunocompromised patient with ulcerative colitis

Jansen, Laura E.; Vos, Xander G; Löwenberg, Mark

doi:10.12998/wjcc.v4.i2.60

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…Only 2 herpetic tonsillitis cases, 3 herpetic pharyngitis cases, and 1 herpetic laryngitis case in adults have been reported. [7][8][9][10][11] We report the first case of herpetic nasopharyngitis. It is worth noting that in all of these cases, the onset was gradual.…”

Section: Discussionmentioning

confidence: 99%

Acute Herpetic Nasopharyngitis in an Adult Patient: A Case Report and Literature Review

Kuo

Piccillo

DeGiovanni

et al. 2022

Ann Otol Rhinol Laryngol

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Objective: To report a case of herpes virus-associated nasopharyngitis in an adult patient. Methods: The patient’s medical record was reviewed for demographic and clinical data. For literature review, all case reports or other publications published in English literature were identified using Pubmed with the MeSH terms “herpes,” “nasopharyngitis,” and “upper respiratory infection.” Results: A 40-year-old male presented for nasal congestion and a suspected nasal mass. Computed tomography of the sinuses revealed edematous changes in the nasopharynx which exerted a downward mass effect at the right aspect of the soft palate. Flexible fiberoptic laryngoscopy (FFL) revealed a lesion arising from the posterior aspect of the soft palate with extension into the posterior nasal cavity as well as copious mucopurulent secretions consistent with a superimposed acute sinusitis. Rigid nasal endoscopy demonstrated a friable and ulcerated lesion arising from the aforementioned anatomical location. Biopsy of this lesion and subsequent immunohistochemical analysis revealed a diagnosis of herpetic nasopharyngitis. Conclusions: Herpetic infection should be in the differential diagnosis of patients presenting with atypical symptoms of nasopharyngitis. Early accurate diagnosis and appropriate specific management can limit the duration of disease course and prevent further complications.

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Section: Discussionmentioning

confidence: 99%

Acute Herpetic Nasopharyngitis in an Adult Patient: A Case Report and Literature Review

Kuo

Piccillo

DeGiovanni

et al. 2022

Ann Otol Rhinol Laryngol

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“…Following from this, it would not be unexpected for patients on TNF α inhibitors to have increased rates of viral herpes infections. Indeed, there are a large number of reports of herpes zoster infections in patients on Infliximab as well as case reports of HSV-1 encephalitis, necrotizing tonsillitis, and diffuse cutaneous infection in patients treated with Infliximab [29–32]. Therefore, it would not be unreasonable to believe that HSV reactivation could cause viral hepatitis in a patient on a TNF α inhibitor.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Hepatic Failure in a Patient with Crohn’s Disease on Infliximab Possibly Related to Reactivation of Herpes Simplex Virus 2 Infection

Golds

Worobetz

2016

Case Reports in Hepatology

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HSV hepatitis is a rare but often fatal cause of liver failure which tends to affect immunocompromised individuals. Early treatment with Acyclovir has been shown to reduce mortality in HSV hepatitis making recognition of the condition critically important. Here, we present a case of HSV hepatitis in a young woman with Crohn's disease on Prednisone, Azathioprine, and Infliximab. We discuss the clinical presentation of HSV hepatitis as well as the possible causes of hepatitis in a patient on these medications. This case helps demonstrate the importance of early clinical suspicion for HSV in undifferentiated fulminate liver failure. It is also the first reported case of HSV hepatitis in a patient on Infliximab, raising the possibility of HSV reactivation in patients on Infliximab.

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“…Herpes simplex virus (HSV) infection (more specifically HSV-1) can cause an atypical viral tonsillitis. The typical vesicular lesions seen around the lips in HSV-1 can spread to other parts of the oral cavity, including the tonsils and thus give the impression of tonsillitis (Jansen et al, 2016).…”

Section: Herpes Simplex Virusmentioning

confidence: 99%

Tonsillitis

Castro

Mahamud

Garg

et al. 2023

InnovAiT: Education and inspiration for general practice

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Tonsillitis is a common condition characterised by the inflammation of lymphoid tissue within the pharynx, with associated inflammation of the rest of the pharynx (pharyngitis). The tonsils belong to Waldeyer’s ring, the ring of mucous-associated lymphoid tissue in the pharynx consisting of the palatine tonsils (known as the tonsils), tubal tonsils (posterior to the Eustachian tube), lingual tonsil (on the tongue base) and the pharyngeal tonsils (adenoids). Tonsillitis commonly refers to inflammation of the palatine tonsils, located laterally within the oropharynx. They lie within a capsule between the anterior arch and posterior arch, comprised of the muscles palatoglossus and palatopharyngeus respectively.

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Herpes simplex induced necrotizing tonsillitis in an immunocompromised patient with ulcerative colitis

Cited by 5 publications

References 10 publications

Acute Herpetic Nasopharyngitis in an Adult Patient: A Case Report and Literature Review

Acute Herpetic Nasopharyngitis in an Adult Patient: A Case Report and Literature Review

Fulminant Hepatic Failure in a Patient with Crohn’s Disease on Infliximab Possibly Related to Reactivation of Herpes Simplex Virus 2 Infection

Tonsillitis

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