Herpes Serology for Dermatologists

Goldman, Barry

doi:10.1001/archderm.136.9.1158

Cited by 31 publications

(30 citation statements)

References 18 publications

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“…122 Viral shedding in the absence of clinical symptoms or in people unaware of their infectious status accounts for almost 70% of all genital HSV2 infections. 24,59,64,123 Women are at a greater overall risk of acquiring genital herpes and, in particular, HSV1-induced genital disease compared with men. 48,59,64 Viral transmission is also more than 4 times more likely from male to female than vice versa.…”

Section: Genital Herpesmentioning

confidence: 99%

Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management

Fatahzadeh¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

440

431

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Section: Genital Herpesmentioning

confidence: 99%

Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management

Fatahzadeh¹,

Schwartz²

2007

Journal of the American Academy of Dermatology

440

431

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“…Which group of patients will benefit from an additional type-specific serology is still under debate [44]. …”

Section: Discussionmentioning

confidence: 99%

The Heterogeneous Clinical Spectrum of Genital Herpes

Lautenschlager

Eichmann²

2001

Dermatology

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Background and Objective: Most data of genital herpes have been collected in STD clinics in the USA where unrecognized forms accounted for 80% of HSV-2 infections. Our aim was to study the clinical features in an outpatient clinic of dermatology. Methods: The charts of 170 patients, previously monitored prospectively for a HIV prevalence study, with culture-confirmed genital herpes or herpetic infection with HSV-2 at any other site presenting between 1995 and 1999 were analyzed. Results: 111 (65%) men and 59 (35%) women were identified with a mean age of 44 years. Only 49% had a typical cluster of genital lesions. Eighty-six (51%) presented with either lesions at extragenital sites [mostly the buttocks 33/170 (19%), thigh 10/170 (6%), anal region 9/170 (5%) and fingers 8/170 (5%)] or showed morphologically atypical forms of isolated genital lesions [single ulcer 16/170 (9%), erosion 6/170 (4%), crust 3/170 (2%) and fissure, edema or erythema each 1/170 (1%)]. Women significantly presented more often with extragenital infections of HSV-2 [36/59 (61%)] than men [18/111 (16%)]. Conclusions: More than half of the patients with genital herpes of a mainly immunocompetent population presented with atypical manifestations. The underdiagnosis of genital herpes seems largely due to misinterpretation of atypical genital and extragenital lesions.

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“…The time required for serological diagnosis is longer than that available for the initiation of treatment [65]. The definitive epidemiological test has been the Western Blot; however, this is generally only available in research institutes and is very expensive [69]. Recently, new serological tests for specific antibodies for HSV-1 and HSV-2 have become commercially available [70][71][72].…”

Section: Herpesmentioning

confidence: 99%

“…During recurrences, samples should preferentially be collected in the vesicular phase, not when lesions are crusted [74]. Moreover, most patients who are seropositive according to Western Blot are unaware of their symptoms (unrecognized infection), or they present subclinical infection and do not undergo culture [69]. Diagnostic technology examining nucleic acids has also proved to be viable for the detection and typing of HSV and may be able to substitute culture as the definitive method [75,76].…”

Section: Herpesmentioning

confidence: 99%

Sexually-transmitted viral diseases in women: clinical and epidemiological aspects and advances in laboratory diagnosis

Pinto¹,

Baggio²,

Guedes³

2005

Braz J Infect Dis

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Sexually transmitted diseases (STDs) have long been known, but they have only recently been recognized as causes of significant long-term morbidity, mainly as a result of increased knowledge concerning viral STDs. The relationship of these diseases with conditions such as anogenital cancer and acquired immunodeficiency syndrome (AIDS) has made viral STDs an important issue in the healthcare of women and infants, and in reproductive health. The evolution of the AIDS pandemic is now characterized by growing differences between rich and poor nations. New diagnostic tools include rapid tests of blood, urine and saliva samples. New techniques, such as computerized cytology, have been developed for the diagnosis of human papillomavirus (HPV). Women infected with HIV are at a greater risk of being co-infected with HPV, and they are also more prone to the progression and persistence of HPV lesions. The herpes simplex virus presents high rates of co-infection with HIV, and it plays a particularly important role in increasing transmission rates of this virus.

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Herpes Serology for Dermatologists

Cited by 31 publications

References 18 publications

Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management

Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management

The Heterogeneous Clinical Spectrum of Genital Herpes

Sexually-transmitted viral diseases in women: clinical and epidemiological aspects and advances in laboratory diagnosis

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