Herpes gestationis may present itself as a paraneoplastic syndrome of choriocarcinoma—a case report

Djahansouzi, S.; Nestle-Kraemling, Carolin; Dall, P.; Bender, H. G.; Hanstein, Bettina

doi:10.1016/s0090-8258(03)00070-2

Cited by 24 publications

(11 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,3,4 In a small number of cases, the disease can be a paraneoplastic manifestation of trophoblastic tumors, hydatiform mole, or choriocarcinoma. 5,6 It sometimes relapses with the onset of menses or use of oral contraceptives postpartum but quickly remits after their discontinuation. 4,7,8 In PG, an immune response against the hemidesmosomal protein BP180, also designated as type XVII collagen or BPAG2, is executed.…”

Section: Epidemiology and Clinical Presentationmentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

View full text Add to dashboard Cite

Section: Epidemiology and Clinical Presentationmentioning

confidence: 99%

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Sadik

Lima

Zillikens

2016

Clinics in Dermatology

View full text Add to dashboard Cite

“…PG is a perinatal, autoimmune, pruritic, and vesiculobullous skin disorder, pathophysiologically resembling bullous pemphigoid. PG also occurs in moles [9–12] and choriocarcinomas [13, 14]. PG should be differentiated from several perinatal pruritic dermatoses such as pruritic urticarial papules and plaques of pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole

Matsumoto¹,

Osada

Kaneko³

et al. 2013

Case Reports in Obstetrics and Gynecology

View full text Add to dashboard Cite

Pemphigoid gestationis (PG) is a rare, perinatal, autoimmune, and blistering dermatosis. Only few cases of PG involving hydatidiform moles have been reported. Complete hydatidiform moles are usually evacuated by dilatation and curettage. We report a patient with a massive complete hydatidiform mole that underwent spontaneous expulsion; she subsequently developed PG. A 19-year-old unmarried nulligravid woman was referred to our hospital following excessive vaginal bleeding after an uncertain amenorrheal period. The patient presented with preshock vital signs, severe anemia, and a positive urine pregnancy test. Imaging examinations revealed a massive intrauterine mass (19 × 15 × 10 cm), suggesting a complete hydatidiform mole. She was hospitalized and treated with blood transfusion. Sixteen hours after hospitalization, the massive molar mass underwent spontaneous expulsion and bleeding ceased. Three days after the expulsion, she developed pruritic skin lesions including papules, erythemas, and bullae, which spread over her entire body. Skin biopsy revealed PG and subepidermal blister formation and linear complement C3 deposition along the basement membrane zone, and the serum anti-BP180 antibody level was found to be high on measurement. She was effectively treated with 50 mg/day of oral prednisolone. Her skin lesions disappeared, leaving pigmentation.

show abstract

“…De même, la faible fréquence de l'antigène HLA Dr4 chez les Afro-américains peut expliquer pour partie la rareté de la PG dans cette population [1]. Dans d'exceptionnelles observations, une PG a évolué comme un syndrome paranéoplasique en révélant un choriocarcinome [10] ; elle peut également être associée à une môle hydatiforme.…”

Section: éPidémiologieunclassified

Pemphigoïde gravidique

Estève¹

2010

La Presse Médicale

View full text Add to dashboard Cite

Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis associated with pregnancy. Its previous designation, herpes gestationis, is obsolete. PG is characterized by a subepidermic separation induced by the presence of peripheral blood autoantibodies against two hemidesmosomal antigens: BPAG1 and BPAG2. Clinical diagnosis is confirmed by histology and positive cutaneous immunofluorescence tests. The most discriminant examination for other pruritic dermatoses of pregnancy is the enzyme-linked immunosorbent assay (Elisa) NC16A BP 180. First-line treatment is local corticosteroid therapy; if local treatment fails, general corticosteroid therapy should be administered. The prognosis is good for mother and child, except that there is a risk of preterm delivery and of moderate fetal growth restriction. Management in a specialized setting is therefore necessary. Recurrence is possible during subsequent pregnancies.

show abstract

Herpes gestationis may present itself as a paraneoplastic syndrome of choriocarcinoma—a case report

Cited by 24 publications

References 3 publications

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Pemphigoid gestationis: Toward a better understanding of the etiopathogenesis

Pemphigoid Gestationis after Spontaneous Expulsion of a Massive Complete Hydatidiform Mole

Pemphigoïde gravidique

Contact Info

Product

Resources

About