“…there appears to be an association with an inflammatory cell infiltrate predominantly made up of eosinophils, which may be the cause of BM disruption [5,15,17]. The release of major basic protein (MBP) from eosinophils and its subsequent association with antigens present in damaged tissue was proposed [15] to present the immune system with a novel antigenic complex, leading to autoantibody synthesis and possibly providing an inflammatory cell chemotactic stimulus. Interestingly, it has been shown that a constituent of blister fluid converted normodense guinea-pig eosinophils to a hypodense, activated state [18].…”