Heronamides with unreported skeletons from deep-sea Streptomyces: discovery and biosynthesis

Abstract

Heronamides M-Q (1−5), five new polyketide macrolactams, among which 1 and 2 feature unreported 6/6/6/5/5-pentacyclic and 6/9/6/5-tetracyclic skeletons, respectively; along with four known heronamides (6−9) were isolated from the deep-sea-derived...