Heroin use and neuropsychological impairments: comparison of intravenous and inhalational use

Ghosh, Abhishek; Shaktan, Alka; Nehra, Ritu; Basu, Debasish; Verma, Abhishek; Rana, Devender Kumar; Modi, Manish; Ahuja, Chirag

doi:10.1007/s00213-023-06332-8

Cited by 4 publications

(2 citation statements)

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“…It is presently unknown if these findings also extend to female rats or if opioid inhalation produces effects similar to those observed after injection. The importance of the latter is especially highlighted by the findings of Ghosh and colleagues (2023).…”

Section: Introductionmentioning

confidence: 99%

“…For example, memory impairments resulting from opioid abuse have been reported in adult (Kroll et al 2018; Ornstein et al 2000) and adolescent humans (Vo et al 2014). One recent study, which studied a number of cognitive domains in heroin users, found that cognitive impairment was specifically related to the route of administration) used (Ghosh et al 2023); intravenous injection was associated with memory deficits while inhalation was associated with decreased ability to maintain attentional set. Injecting rodents with opioid drugs can likewise impair performance on tests of impulsivity (Pattij et al 2009), cognitive flexibility (You et al 2022), and working memory (Braida et al 1994).…”

Section: Introductionmentioning

confidence: 99%

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Persistent effects of repeated adolescent and adult heroin vapor inhalation in female Wistar rats

Gutierrez,

Taffe

2024

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Adolescent drug exposure has been associated with more severe mental health outcomes related to substance abuse and anxiety disorders. The aim of the present study was to contrast the long-term effects of repeated heroin vapor inhalation during adolescence with similar heroin exposure in adulthood. Groups of female Wistar rats underwent twice daily 30-minute sessions of heroin or propylene glycol (control) vapor inhalation from postnatal days (PND) 36-45 or PND 85-94, respectively. Nociception was assessed after vapor inhalation sessions and forty days later, for the Adolescent-Exposed and Adult-Exposed groups. Anxiety-like behavior was assessed with an elevated plus-maze (EPM) and spatial learning was assessed with a Barnes maze. Acute effects of naloxone (0.3 mg/kg, i.p.) and heroin (0.5 and 1.0 mg/kg, s.c.) on thermal nociception were determined on PND 140/189 and PND 149/198, respectively. Repeated heroin vapor inhalation produced anti-nociceptive tolerance across sessions in both adolescent and adult rats, with the adolescents exhibiting more complete tolerance. Heroin vapor inhalation produced anxiolytic effects, regardless of age of exposure. There were no effects of heroin on spatial learning. Naloxone produced acute hyperalgesia in all but the Adolescent-Exposed heroin group, and heroin anti-nociception was blunted in both heroin-exposed groups at the highest heroin dose. Repeated heroin vapor inhalation can produce lasting effects on nociception and anxiety-like behavior that persist for months after the exposure. Importantly, these findings suggest that adolescent exposure to heroin vapor produces specific effects on nociception that are not observed when exposure occurs in adulthood.

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Section: Introductionmentioning

confidence: 99%