Heroin Addiction Impairs Human Cortical Plasticity

Shen, Ying; Cao, Xinyu; Shan, Chunlei; Dai, Wenjun; Yuan, Ti‐Fei

doi:10.1016/j.biopsych.2016.06.013

Cited by 41 publications

(41 citation statements)

References 10 publications

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“…Furthermore, muscular dystrophy may itself change sensory feedback from muscle spindles, which could modify sensorimotor plasticity [12,33]. Hence, rPAS abnormalities may also be considered as an additional epiphenomenon of a multisystem syndrome as the DM1 is.…”

Section: Discussionmentioning

confidence: 99%

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

et al. 2017

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Myotonic dystrophy type 1 (DM1) is the most prevalent adult muscular dystrophy, often accompanied by impairments in attention, memory, visuospatial and executive functions. Given that DM1 is a multi-system disorder, it requires a multi-disciplinary approach, including effective rehabilitation programs, focusing on the central nervous system neuroplasticity, in order to develop patient-tailored rehabilitative procedures for motor function recovery. Herein, we performed a transcranial magnetic stimulation (TMS) study aimed at investigating central motor conduction time, sensory-motor plasticity, and cortical excitability in 7 genetically defined DM1 patients. As compared to healthy individuals, DM1 patients showed a delayed central motor conduction time and an abnormal sensory-motor plasticity, with no alteration of cortical excitability. These findings may be useful to define patient-tailored motor rehabilitative programs.

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Section: Discussionmentioning

confidence: 99%

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

et al. 2017

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“…Treatment of depression was the first major therapeutic goal set for TMS [4]. Other potential applications include schizophrenia [5], Parkinson’s disease [6], Alzheimer’s disease [7], and various addictions [8–11]. In recent years, it has been demonstrated that depression is a disease affecting multiple brain regions [12, 13], which are associated with reward circuits [14, 15], such as the nucleus accumbens (NA), the ventral tegmentum area (VTA), amygdala, and medial prefrontal, cingulate.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation

Ueno

2017

PLoS ONE

101

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Stimulation of deeper brain structures by transcranial magnetic stimulation (TMS) plays a role in the study of reward and motivation mechanisms, which may be beneficial in the treatment of several neurological and psychiatric disorders. However, electric field distributions induced in the brain by deep transcranial magnetic stimulation (dTMS) are still unknown. In this paper, the double cone coil, H-coil and Halo-circular assembly (HCA) coil which have been proposed for dTMS have been numerically designed. The distributions of magnetic flux density, induced electric field in an anatomically based realistic head model by applying the dTMS coils were numerically calculated by the impedance method. Results were compared with that of standard figure-of-eight (Fo8) coil. Simulation results show that double cone, H- and HCA coils have significantly deep field penetration compared to the conventional Fo8 coil, at the expense of induced higher and wider spread electrical fields in superficial cortical regions. Double cone and HCA coils have better ability to stimulate deep brain subregions compared to that of the H-coil. In the mean time, both double cone and HCA coils increase risk for optical nerve excitation. Our results suggest although the dTMS coils offer new tool with potential for both research and clinical applications for psychiatric and neurological disorders associated with dysfunctions of deep brain regions, the selection of the most suitable coil settings for a specific clinical application should be based on a balanced evaluation between stimulation depth and focality.

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“…Preclinical studies of heroin addiction have revealed neural system disturbances, including abnormal alteration of dendritic spines, mitochondrial dysfunction, and neuronal apoptosis . In human studies, chronic heroin users were reported to exhibit diffuse gray and white matter injury, abnormal functional organization, and diminished cortical plasticity . These findings support the presence of structural and functional damage in patients with HD.…”

Section: Introductionmentioning

confidence: 79%

NGF gene polymorphisms are not associated with heroin dependence in a Taiwanese male population

et al. 2018

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Heroin Addiction Impairs Human Cortical Plasticity

Cited by 41 publications

References 10 publications

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

Toward a more personalized motor function rehabilitation in Myotonic dystrophy type 1: The role of neuroplasticity

Comparison of the induced fields using different coil configurations during deep transcranial magnetic stimulation

NGF gene polymorphisms are not associated with heroin dependence in a Taiwanese male population

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