Heritable and Nonheritable Rumen Bacteria Are Associated with Different Characters of Lactation Performance of Dairy Cows

Zang, Xin-Wei; Sun, Hui-Zeng; Xue, Mingyuan; Zhang, Zhe; Plastow, Graham; Yang, Tong; Guan, Le Luo; Liu, Jianxin

doi:10.1128/msystems.00422-22

Cited by 13 publications

(17 citation statements)

References 56 publications

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“…The animal care and experimental procedures were approved by the Animal Care Committee of Zhejiang University (Hangzhou, China). Seventeen pairs of mother cows and their respective offspring were selected from a cohort of 361 healthy mid-lactation Holstein dairy cows housed at a commercial dairy farm [ 6 ], based on their pedigree records. The animals were reared under the same dairy farm environment and management with a concentrate-to-forage ratio of 57:43 (dry matter basis) [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Seventeen pairs of mother cows and their respective offspring were selected from a cohort of 361 healthy mid-lactation Holstein dairy cows housed at a commercial dairy farm [ 6 ], based on their pedigree records. The animals were reared under the same dairy farm environment and management with a concentrate-to-forage ratio of 57:43 (dry matter basis) [ 6 ]. Rumen contents were collected using an oral stomach tube before morning feeding and were used to measure volatile fatty acids (VFAs).…”

Section: Methodsmentioning

confidence: 99%

“…[ 5 ] identified 39 genera of core rumen bacteria that have significant heritability and showed significantly higher explanatory power for dairy cow’s phenotypes compared to other nonheritable core microbes. Similarly, our previous study found 32 heritable bacteria at species level and identified 63 host single nucleotide polymorphisms (SNP) associated with heritable bacteria [ 6 ]. In beef cattle, 59 rumen microbial taxa (at various classification levels) were identified to be heritable and 5 SNP were identified that were associated with both rumen heritable microbial taxa and feed efficiency traits [ 4 ].…”

Section: Introductionmentioning

confidence: 93%

“…This is because the rumen microbiota in adult cows and their offspring exhibit a more stable composition and function compared to newborn or young cows. Our previous study revealed that heritable bacteria had a more significant average contribution to the lactation phenotype compared to nonheritable bacteria [ 6 ]. However, it remained unknown whether heritable bacteria can be transmitted from mother to offspring.…”

Section: Introductionmentioning

confidence: 99%

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Genotype-associated heritable rumen bacteria can be a stable microbiota passed to the offspring

Zang,

Sun,

Xue

et al. 2024

ISME Communications

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Recent studies have reported that some rumen microbes are “heritable” (those have significant narrow sense heritability) and can significantly contribute to host phenotype variations. However, it is unknown if these heritable rumen bacteria can be passed to the next generation. In this study, the rumen bacteria from mother cows (sampled in 2016) and their offspring (sampled in 2019) were assessed to determine if vertical transmission occurred between the two generations. The analysis of relationship between host genotypes and heritable bacterial abundances showed that potential of five host genotypes can affect the relative abundances of two unclassified species level heritable bacteria (Pseudoscardovia, and p-251-o5). The G allele of BTB-01532239 and A allele of ARS-BFGL-NGS-8960 were associated with a higher relative abundance of p-251-o5. The A allele of BTB-00740910 and BovineHD1300021786, and G allele of BovineHD1900005868 were associated with a higher relative abundance of Pseudoscardovia. The mother-offspring comparison revealed that the heritable rumen bacteria had higher compositional similarity than nonheritable bacteria between two generations, and the predicted heritable microbial functions had higher stability than those from non-heritable bacteria. These findings suggest that a high stability exists in heritable rumen bacteria, which could be passed to the next generation in dairy cows.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genotype-associated heritable rumen bacteria can be a stable microbiota passed to the offspring

Zang,

Sun,

Xue

et al. 2024

ISME Communications

Self Cite

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“…The scale of broad-sense heritability ranges from 0 to 1, where a value of 1 indicates that all variance is attributed to genetics. Heritability was classi ed into high (H 2 > 0.4), moderate (0.2 < H 2 < 0.4) and low (H 2 < 0.2) based on the range of the values (Zang et al 2022).…”

Section: Relationships Between Wheat Varieties and Fungal Communitiesmentioning

confidence: 99%

Linking root-associated fungal communities, wheat evolutionary patterns, and productivity: overlooked roles of rare taxa

Kang,

Zheng,

Feng

et al. 2023

Preprint

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Background and Aims The intricate relationships between root-associated fungal communities and wheat plants can potentially impact plant health, crop yield, and quality. However, the interplay among various wheat varieties, fungal communities, and wheat productivity remains understudied. Methods In this study, 95 wheat varieties in China were selected. Plant and soil samples were collected during two wheat growth stages (regreening and heading). DNA extraction and genotyping were performed, and fungal ASVs were categorized based on abundance. Fungal community diversity, assembly mechanisms, and relationships were examined. Co-occurrence networks were used to identify keystone taxa. Relationships between wheat genetics, quality, yield, and fungal communities were assessed. Broad-sense heritability (H2) of root-associated ASVs was calculated. Results Abundant and core taxa significantly influenced fungal community structure, with stochastic processes mainly driving the assembly. Regreening stage's rhizosphere harbored keystone taxa, though a weak but meaningful connection existed between wheat genetic distance and rare taxa at the heading stage. Wheat quality and yield were significantly (P < 0.05) influenced by rare rhizosphere taxa during regreening stage, while heading stage yield correlated positively with keystone taxa and Glomeromycota. Rhizosphere abundant subcommunity was more specialized in enriching taxa with low and moderate heritability, while rare subcommunity was better at recruiting high-heritability (H2 > 0.4) taxa. Conclusions Abundant and core taxa played a substantial role in shaping fungal communities during wheat growth, but less abundant rhizosphere species were also vital, as they attained keystone status, showed genetic ties to the host, and were related to wheat quality and yield with higher heritability.

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Deciphering functional groups of rumen microbiome and their underlying potentially causal relationships in shaping host traits

Xue,

Xie,

Zang

et al. 2024

iMeta

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Over the years, microbiome research has achieved tremendous advancements driven by culture‐independent meta‐omics approaches. Despite extensive research, our understanding of the functional roles and causal effects of the microbiome on phenotypes remains limited. In this study, we focused on the rumen metaproteome, combining it with metatranscriptome and metabolome data to accurately identify the active functional distributions of rumen microorganisms and specific functional groups that influence feed efficiency. By integrating host genetics data, we established the potentially causal relationships between microbes‐proteins/metabolites‐phenotype, and identified specific patterns in which functional groups of rumen microorganisms influence host feed efficiency. We found a causal link between Selenomonas bovis and rumen carbohydrate metabolism, potentially mediated by bacterial chemotaxis and a two‐component regulatory system, impacting feed utilization efficiency of dairy cows. Our study on the nutrient utilization functional groups in the rumen of high‐feed‐efficiency dairy cows, along with the identification of key microbiota functional proteins and their potentially causal relationships, will help move from correlation to causation in rumen microbiome research. This will ultimately enable precise regulation of the rumen microbiota for optimized ruminant production.

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Heritable and Nonheritable Rumen Bacteria Are Associated with Different Characters of Lactation Performance of Dairy Cows

Cited by 13 publications

References 56 publications

Genotype-associated heritable rumen bacteria can be a stable microbiota passed to the offspring

Genotype-associated heritable rumen bacteria can be a stable microbiota passed to the offspring

Linking root-associated fungal communities, wheat evolutionary patterns, and productivity: overlooked roles of rare taxa

Deciphering functional groups of rumen microbiome and their underlying potentially causal relationships in shaping host traits

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