Heritability of reproductive hormones in adult male twins

Kuijper, E.A.M.; Lambalk, Cornelis B.; Boomsma, Dorret I.; Sluis, Sophie van der; Blankenstein, Marinus A.; Geus, Eco J. C. de; Posthuma, Daniëlle

doi:10.1093/humrep/dem145

Cited by 56 publications

(39 citation statements)

References 40 publications

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“…Thus, higher levels of testosterone in males lead to increased reproductive fitness early in life while causing decreased fitness later in life due to a higher risk of prostate cancer (Summers and Crespi 2008). Both testosterone (Kuijper et al 2007;Harris et al 1998) and estrogen (Martini et al 2001) are heritable; thus, there is a need for researches to step in and link heritability of reproductive hormones to that of the longevity. Table 1 presents a list of the above musculoskeletal traits that have been extensively studied by several cohort studies, along with their change with age.…”

Section: Biochemical and Endocrine Serum Markersmentioning

confidence: 99%

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Karasik

2010

AGE

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Genetic study can provide insight into the biologic mechanisms underlying inter-individual differences in susceptibility to (or resistance to) organisms' aging. Recent advances in molecular genetics and genetic epidemiology provide the necessary tools to perform a study of the genetic sources of biological aging. However, to be successful, the genetic study of a complex condition requires a heritable phenotype to be developed and validated. Genome-wide association studies offer an unbiased approach to identify new candidate genes for human diseases. It is hypothesized that convergent results from multiple aging-related traits will point out the genes responsible for the general aging of the organism. This perspective focuses on the musculoskeletal aging as an example of an approach to identify a downstream common pathway that summarizes aging processes. Since the musculoskeletal traits are linked to the state of many vital functions, disability, and ultimately survival rates, we postulate that there is significance in studying musculoskeletal aging. Construction of an integrated phenotype of aging can be achieved based on shared genetics among multiple musculoskeletal biomarkers. Valid biomarkers from other systems of the organism should be similarly explored. The new composite aging score needs to be validated by determining whether it predicts all-cause mortality, incidences of major chronic diseases, and disability late in life. Comprehensive databases on biomarkers of musculoskeletal aging in multiple large cohort studies, along with information on various health outcomes, are needed to validate the proposed measure of biological aging.

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Section: Biochemical and Endocrine Serum Markersmentioning

confidence: 99%

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Karasik

2010

AGE

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“…For example, testosterone has familial correlations and genetic determinants (8 ), and estrogen also correlates with genetic polymorphisms (7,9,10 ). Results of recent studies in twins showed a high heritability of plasma sex hormone concentrations among adult male twins, with heritability of 57% for testosterone (11,12 ).…”

confidence: 99%

Association of SRD5A2 Variants and Serum Androstane-3α,17β-Diol Glucuronide Concentration in Chinese Elderly Men

Jiang¹,

Tang²,

Ohlsson

et al. 2010

Clinical Chemistry

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BACKGROUND:Results of recent studies have demonstrated that genetic variants of the enzyme steroid 5␣ reductase type II (SRD5A2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3␣,17␤-diol-glucuronide (3␣-diol-G). However, this association was not consistently found among different ethnic groups. Thus, we aimed to determine whether the association with SRD5A2 genetic variations exists in a cohort of healthy Chinese elderly men, by examining 2 metabolite conjugates: androstane-3␣,l7␤-diol-3-glucuronide (3␣-diol-3G) and androstane-3␣,17␤-diol-17-glucuronide (3␣-diol-17G).

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“…It is important to note, however, that the level of free testosterone is not determined solely by genes, and that in adult men environmental influences account for roughly 50% of the variance in testosterone level. 35,36 Further examination of this relationship will need to establish candidate genetic and environmental factors that influence testosterone levels in order to determine if they indeed interact with APOE genotype.…”

mentioning

confidence: 99%

Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men

Panizzon

Hauger²,

Dale³

et al. 2010

Neurology

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Heritability of reproductive hormones in adult male twins

Abstract: All measured hormones are highly heritable. A difference in the FSH-inhibin B feedback system between DZ twin males and MZ twin males could not be confirmed.

Cited by 56 publications

References 40 publications

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

How pleiotropic genetics of the musculoskeletal system can inform genomics and phenomics of aging

Association of SRD5A2 Variants and Serum Androstane-3α,17β-Diol Glucuronide Concentration in Chinese Elderly Men

Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men

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