Heritability of Recurrent Tonsillitis

Abstract

To estimate the relative contribution of genetic and environmental effects on the variance in the liability of recurrent tonsillitis.

Recurrent otitis media and tonsillitis: common disease predisposition

“…A substantial genetic predisposition for otitis media [6][7][8] and tonsillectomy [9] has previously been reported. Heritability estimates of otitis media [10] and tonsillitis [11] based on the present study population has also previously been reported. Genetic effects, comprising both additive and non-additive effects, explained 62% of the liability to recurrent tonsillitis and there were no sex differences in the genetic source or in the size of the genetic effects.…”

Pattern of Otolaryngological Diseases among Paediatric Population Attending ENT OPD in a Tertiary Care Centre, Dhaka

“…The underlying cause of epistaxis is local inflammatory lesion, infection, trauma usually by nose pricking. 12 Most of bleeding is self limiting. There is scanty availability of data on prevalence of epistaxis in children.…”

Toll-Like Receptor 4 Gene ( TLR4 ), but Not TLR2 , Polymorphisms Modify the Risk of Tonsillar Disease Due to Streptococcus pyogenes and Haemophilus influenzae

“…This suggests that TLR4 mutations might act in concert with other genetic changes or acquired factors to influence the complex immunologic response to pathogens. For example, the cocolonization of interspecies (GAS versus Haemophilus influenzae) might be common, and these species may have evolved to have specific mechanisms for targeting one another (14). Thus, the altered immune responses due to the presence of a functional polymorphism could facilitate the colonization of one species (for example, that of GAS in tonsils), preventing the colonization of the other (e.g., Haemophilus influenzae).…”

“…Therefore, the emerging and still unanswered questions are why are some individuals more susceptible to tonsillar infections, as well as why do some of them suffer from infections by specific bacteria? Although environmental factors, such as day care attendance or the number of siblings, influence the morbidity from common bacteria (1), it is noteworthy that a genetic predisposition for tonsillar disease has also been observed (14).…”