Heritability of mandibular cephalometric variables in twins with completed craniofacial growth

Šidlauskas, Mantas; Šalomskienė, Loreta; Andriuškevičiūtė, Irena; Šidlauskienė, Monika; Labanauskas, Žygimantas; Vasiliauskas, Arūnas; Kupčinskas, Limas; Juzėnas, Simonas; Šidlauskas, Antanas

doi:10.1093/ejo/cjv062

Cited by 45 publications

(86 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The heritability in our study was highest with 79% for the ratio of lower anterior face height to anterior face height (LAFH/AFH). This finding is according to pertinent literature, which showed that heritability seems to have more influence on anterior vertical parameters than posterior . Furthermore, it seems that the lower third of the face is under strong genetic control .…”

Section: Discussionsupporting

confidence: 80%

“…This is on par with former studies on siblings that indicated that the heritability of skeletal craniofacial variables increases with age . Previous studies on several skeletal cephalometric parameters indicated high heritability, with higher heritability values among vertical, compared with horizontal variables; however, Sidlauskas et al stated that horizontal linear variables were more genetically determined than vertical variables.…”

Section: Discussionsupporting

confidence: 49%

“…According to Manfredi et al anterior vertical parameters show greater heritability than posterior ones, while the shape of the mandible shows greater heritability than its size . The latter finding was confirmed by recent evidence indicating that the angular measurements representing mandibular skeletal morphology (mandibular form) had greater genetic determination than its absolute size …”

Section: Introductionmentioning

confidence: 82%

See 2 more Smart Citations

Vertical growth in mono‐and dizygotic twins: A longitudinal cephalometric cohort study

Hersberger-Zurfluh

Papageorgiou

Motro

et al. 2019

Orthod Craniofacial Res

View full text Add to dashboard Cite

Objective The aims of this longitudinal analysis of untreated monozygotic and dizygotic twins were to investigate vertical changes of the craniofacial structures during growth, to determine the concordance between genetically twins and to assess the genetic component for the various aspects of vertical growth. Settings and sample population The sample consisted of 34 pairs of untreated monozygotic twins (23 male, 11 female) and 30 untreated dizygotic siblings of multiple birth (8 male, 8 female and 14 mixed) from the Forsyth Moorrees Twin Study (1959‐1975); lateral cephalograms taken from 6 to 18 years of age were analysed at 3‐year intervals. Materials and Methods Cephalograms were traced, and longitudinal changes between twins in six angular and proportional vertical cephalometric variables (SN‐NL, ML‐NL, SN‐ML, y‐axis, PFH/AFH and LAFH/AFH) were analysed with intraclass correlation coefficients and linear regression modelling. Results The concordance between monozygotic/dizygotic twins at 18 years of age was moderate to high with intraclass correlation coefficient values between 0.51 and 0.66. Additionally, sex differences in concordance at 18 years of age were found for three variables. High heritability (66%‐79%) was observed for 5 of the 6 variables (LAFH/AFH, ML‐NL, y‐axis, SN‐ML, PFH/AFH), while SN‐NL showed limited heritability (34%). Conclusions Although monozygotic/dizygotic twins share at least part of their genetic material, differences in the vertical dimension were found. This supports the complex developmental mechanism of the human face and the varying influence of genetic and environmental factors.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 82%

See 1 more Smart Citation

Vertical growth in mono‐and dizygotic twins: A longitudinal cephalometric cohort study

Hersberger-Zurfluh

Papageorgiou

Motro

et al. 2019

Orthod Craniofacial Res

View full text Add to dashboard Cite

show abstract

“…The current investigation confirmed high heritability of the gonial angle, cervical lordosis, hyoid position and the velopharyngeal and hypopharyngeal dimensions. The high genetic influence of gonial angle and the hyoid position have been reported in previous reports . Although previous studies suggested the heritability of structures of the oropharynx, the heritability of oropharyngeal dimensions seemed to be lower than those of velopharynx and hypopharynx from aforementioned results.…”

Section: Discussionmentioning

confidence: 58%

“…For better understanding of the precise contribution of genetic and environmental background of OSA, investigating heritability of the airway anatomy would be necessary. The genetic influences of skeletal and soft tissue structures in normal subjects have been proposed . In addition to normal subjects, OSA patients have also presented familial similarities of craniofacial structures related to the airway dimensions …”

Section: Introductionmentioning

confidence: 99%

Heritability of the airway structure and head posture using twin study

Kang

Sung

Song

et al. 2018

J of Oral Rehabilitation

View full text Add to dashboard Cite

Inherited traits of obstructive sleep apnoea (OSA) may have link to the heritability of the airway anatomy. The aim of this study was to investigate heritability of the airway anatomy by comparing skeletal and soft tissue features of Korean monozygotic twins (MZ) and dizygotic twins (DZ). In total, 72 participants (mean age, 41.5 ± 5.9 years; 40 males, 32 females) including 48 MZ (24 pairs) and 24 DZ (12 pairs) with same sex were participated. The craniofacial, craniovertebral, hyoideal and pharyngeal parameters were measured using lateral cephalograms. The genetic analysis was performed using Falconer's method. High heritability was detected in the hyoid position and inclination of the cervical column. The velopharyngeal and hypopharyngeal dimensions showed higher heritability compared to those of the nasopharynx and oropharynx. The body mass index (BMI) had interactions with the nasopharyngeal and hypopharyngeal dimensions and length of the tongue and soft palate. The mandibular growth had correlations with the nasopharyngeal and hypopharyngeal dimensions. The vertical skeletal relationships appeared to have interaction with the nasopharyngeal, velopharyngeal and hypopharyngeal dimensions, as well as length of the tongue and soft palate. A forwarded inclination of the cervical columns was seen in connections with BMI and the nasopharyngeal and hypopharyngeal dimensions. The airway structures and head postures seemed to be under strong genetic controls. The airway dimensions had associations with BMI, head postures and skeletal structures which showed high heritability. Forwarded head postures would be physiological adaptations of compromised airway adequacy by increased BMI and retrognathia.

show abstract

The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins

et al. 2022

View full text Add to dashboard Cite

While language is expressed in multiple modalities, including sign, writing, or whistles, speech is arguably the most common. The human vocal tract is capable of producing the bewildering diversity of the 7000 or so currently spoken languages, but relatively little is known about its genetic bases, especially in what concerns normal variation. Here, we capitalize on five cohorts totaling 632 Dutch twins with structural magnetic resonance imaging (MRI) data. Two raters placed clearly defined (semi)landmarks on each MRI scan, from which we derived 146 measures capturing the dimensions and shape of various vocal tract structures, but also aspects of the head and face. We used Genetic Covariance Structure Modeling to estimate the additive genetic, common environmental or non-additive genetic, and unique environmental components, while controlling for various confounds and for any systematic differences between the two raters. We found high heritability, h2, for aspects of the skull and face, the mandible, the anteroposterior (horizontal) dimension of the vocal tract, and the position of the hyoid bone. These findings extend the existing literature, and open new perspectives for understanding the complex interplay between genetics, environment, and culture that shape our vocal tracts, and which may help explain cross-linguistic differences in phonetics and phonology.

show abstract

Heritability of mandibular cephalometric variables in twins with completed craniofacial growth

Abstract: The shape and sagittal position of the mandible is under stronger genetic control, than is its size and vertical relationship to cranial base.

Cited by 45 publications

References 27 publications

Vertical growth in mono‐and dizygotic twins: A longitudinal cephalometric cohort study

Vertical growth in mono‐and dizygotic twins: A longitudinal cephalometric cohort study

Heritability of the airway structure and head posture using twin study

The heritability of vocal tract structures estimated from structural MRI in a large cohort of Dutch twins

Contact Info

Product

Resources

About