2015
DOI: 10.1186/s13028-016-0221-8
|View full text |Cite
|
Sign up to set email alerts
|

Heritability of hypothyroidism in the Finnish Hovawart population

Abstract: BackgroundThe Hovawart is a working and companion dog breed of German origin. A few hundred Hovawart dogs are registered annually in Finland. The most common disease with a proposed genetic background in Hovawarts is hypothyroidism. The disease is usually caused by lymphocytic thyroiditis, an autoimmune disorder which destroys the thyroid gland. Hypothyroidism can be treated medically with hormone replacement. Its overall incidence could also be reduced through selection, provided that the trait shows an adequ… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
3
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 22 publications
(37 reference statements)
0
3
0
Order By: Relevance
“…However, it raises the concern that a lack of knowledge regarding the fact that some factors could reduce the sensitivity and specificity of thyroid function tests. Multiple nonthyroidal factors including breed, 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 concurrent illness, 39 , 40 , 41 certain medications, 42 , 43 , 44 , 45 , 46 age, 34 and sex 4 can significantly affect the results of measured TT4, TSH and fT4 concentrations. Drugs such as glucocorticoids, phenobarbital, aspirin, ketoprofen, carprofen, clomipramide, and sulfonamides affect the results of thyroid function tests.…”
Section: Discussionmentioning
confidence: 99%
“…However, it raises the concern that a lack of knowledge regarding the fact that some factors could reduce the sensitivity and specificity of thyroid function tests. Multiple nonthyroidal factors including breed, 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 concurrent illness, 39 , 40 , 41 certain medications, 42 , 43 , 44 , 45 , 46 age, 34 and sex 4 can significantly affect the results of measured TT4, TSH and fT4 concentrations. Drugs such as glucocorticoids, phenobarbital, aspirin, ketoprofen, carprofen, clomipramide, and sulfonamides affect the results of thyroid function tests.…”
Section: Discussionmentioning
confidence: 99%
“…However, the data of the present study cannot clarify this notion. There have been contradictory reports on whether sex and neutering status influence the likelihood of developing hypothyroidism [31,47,50,55,56,[58][59][60]. To date, a clear consensus on a sex-based predisposition is not available.…”
Section: Plos Onementioning
confidence: 99%
“…This leads to the conclusion that the underlying genetics are likely a polygenic trait that varies from one breed to another and that developing hypothyroidism is also heavily influenced by environmental factors. 6 Penetrance of the offending alleles is also likely to have a role in the expression of clinical disease. Despite these drawbacks, there are testing mechanisms that help screen potential breeding stock and assist breeders and veterinarians in choosing animals less likely to pass hypothyroidism on to their offspring.…”
Section: Heritability and Testing Breeding Animalsmentioning
confidence: 99%
“…4,5 Breeds that have a high incidence of thyroglobulin autoantibodies (TgAA) (antithyroglobulin antibodies) include Boxers, Dalmatians, Giant Schnauzers, Great Danes, Setters, and Old English Sheepdogs, among others. 1,[3][4][5][6][7] Diagnosis should be based on serologic testing and not on clinical signs alone as there are many diseases and medications, or even breed differences, that contribute to altered circulating thyroid hormone concentrations. Accurate testing should be utilized before supplementation is considered.…”
mentioning
confidence: 99%