Heritability of fearful-anxious endophenotypes in infant rhesus macaques: a preliminary report

Williamson, Douglas E.; Coleman, Kris; Bacanu, Silviu‐Alin; Devlin, Bernie; Rogers, Jeffrey; Ryan, Neal D.; Cameron, Judy L.

doi:10.1016/s0006-3223(02)01601-3

Cited by 97 publications

(81 citation statements)

References 52 publications

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“…Using this technique, dimensions of human personality, including sociability, have been shown to be heritable (127). Similar findings show that the behavioral tendencies of a number of vertebrate species, including some nonhuman primates (128)(129)(130), are heritable, thus pointing to a (partly) genetic basis for primate social behavior. Not only are social components of personality heritable, but so too is the extent to which individuals are integrated into their social networks in both humans (131) and rhesus macaques (124).…”

Section: Genetic Regulation Of Social Behaviormentioning

confidence: 55%

Neuroethology of primate social behavior

Chang¹,

Brent²,

Adams³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

135

107

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A neuroethological approach to human and nonhuman primate behavior and cognition predicts biological specializations for social life. Evidence reviewed here indicates that ancestral mechanisms are often duplicated, repurposed, and differentially regulated to support social behavior. Focusing on recent research from nonhuman primates, we describe how the primate brain might implement social functions by coopting and extending preexisting mechanisms that previously supported nonsocial functions. This approach reveals that highly specialized mechanisms have evolved to decipher the immediate social context, and parallel circuits have evolved to translate social perceptual signals and nonsocial perceptual signals into partially integrated social and nonsocial motivational signals, which together inform general-purpose mechanisms that command behavior. Differences in social behavior between species, as well as between individuals within a species, result in part from neuromodulatory regulation of these neural circuits, which itself appears to be under partial genetic control. Ultimately, intraspecific variation in social behavior has differential fitness consequences, providing fundamental building blocks of natural selection. Our review suggests that the neuroethological approach to primate behavior may provide unique insights into human psychopathology.decision | evolution | reward | serotonin | oxytocin S ensitivity and responsiveness to information about others is critical for human health (1, 2), survival (3), and even financial success (4). To navigate our social worlds, we track the behavior of others and form models of their intentions and emotional states, we actively seek out and exchange information about others, and we flexibly alter our behavior in response to what we know about others. These faculties are so important to human behavior that their disruption constitutes psychopathology (5, 6). These specializations for social behavior reflect a rich evolutionary heritage of adaptation to group life (7-9). Like humans, many nonhuman primates also live in large groups characterized by patterns of social behaviors like grooming, imitative and cooperative foraging, differentiated affiliative relationships, ritualized courtship and mating behavior, and competitive interactions structured by social dominance (10, 11). Not surprisingly, the ability to deftly navigate the social environment has observable consequences for reproductive success in some nonhuman primates (12). Evolutionary Perspective on Social BehaviorSocial behavior places strong and unique demands on the nervous system. Across primate species, group size (a potential proxy of social complexity) is correlated with forebrain volume, after correcting for body size (9). Additional brain tissue beyond that required to maintain a body of a particular size is costly, in both developmental complexity and metabolic demands (7, 13-15). Indeed, social complexity and the elaboration of neural mechanisms to support it are associated with diets high in dependa...

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Section: Genetic Regulation Of Social Behaviormentioning

confidence: 55%

Neuroethology of primate social behavior

Chang¹,

Brent²,

Adams³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

135

107

View full text Add to dashboard Cite

show abstract

“…23 Genetic analyses in infant rhesus macaques have revealed high heritabilities of anxiety-related behaviors like inhibition and distress responses. 24,25 Temperament characteristics have biological correlates; a wealth of data demonstrate that high impulsivity and aggressiveness are related to reduced serotonin activity. Serotonin is a neurotransmitter involved in control of the neurohormonal stress axis.…”

Section: Consistency Of Social Relations: the Case Of The Rhesus Macaquementioning

confidence: 99%

Unity in diversity: Lessons from macaque societies

Thierry

2007

Evolutionary Anthropology

283

408

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The macaque radiation is as old as the hominin radiation, approximately 7 million years. After Homo, Macaca has the widest geographical range among primates, and both of these genera are present in tropical and temperate regions as well. Whereas the single extant representative of the genus Homo diverged through processes of cultural diversification, extant species of macaques emerged through processes of evolutionary diversification. Macaque societies are characterized by profound unity and great diversity, and can best be described as variations on the same theme. To understand macaque variation and adaptation, we must take into account the processes that insure the persistence of their societies across generations and environments.

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“…[103] As in humans, anxious temperament appears to be highly heritable in rodent and primate models. [85,104,105] As noted earlier, Rgs2 was identified by positional mapping as a contributor to mouse anxious temperament phenotypes resembling BI. [74] The gene encodes a regulator of G-protein signaling that accelerates the deactivation of G-proteins that are second messengers for neurotransmitters including norepinephrine and serotonin.…”

Section: à8mentioning

confidence: 65%

Genetics of anxiety disorders: the complex road from DSM to DNA

2009

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Anxiety disorders are among the most common psychiatric disorders, affecting one in four individuals over a lifetime. Although our understanding of the etiology of these disorders is incomplete, familial and genetic factors are established risk factors. However, identifying the specific casual genes has been difficult. Within the past several years, advances in molecular and statistical genetic methods have made the genetic dissection of complex disorders a feasible project. Here we provide an overview of these developments, with a focus on their implications for genetic studies of anxiety disorders. Although the genetic and phenotypic complexity of the anxiety disorders present formidable challenges, advances in neuroimaging and experimental animal models of anxiety and fear offer important opportunities for discovery. Real progress in identifying the genetic basis of anxiety disorders will require integrative approaches that make use of these biologic tools as well as larger-scale genomic studies. If successful, such efforts may yield novel and more effective approaches for the prevention and treatment of these common and costly disorders.

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Heritability of fearful-anxious endophenotypes in infant rhesus macaques: a preliminary report

Cited by 97 publications

References 52 publications

Neuroethology of primate social behavior

Neuroethology of primate social behavior

Unity in diversity: Lessons from macaque societies

Genetics of anxiety disorders: the complex road from DSM to DNA

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