Heritability estimation of 2D:4D finger ratio in a Chuvashian population‐based sample

Kalichman, Leonid; Batsevich, Valery; Kobyliansky, Eugene

doi:10.1002/ajhb.23212

Cited by 14 publications

(14 citation statements)

References 36 publications

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“…Thus, the findings suggest that the functions of testosterone are not related to individual differences referring to the ratio in adults. Of note, 2D:4D shows a robust heritability (Hiraishi, Sasaki, Shikishima, & Ando, ; Kalichman, Batsevich, & Kobyliansky, ; Medland & Loehlin, ; Richards, Bellin, & Davies, ; Voracek & Dressler, ), while the ratio analyzed in this study is not significantly associated with genetic variations that are involved in testosterone functions. Thus, 2D:4D at individual level might be related to other genetic factors (Butovskaya et al, ; Kondo, Zakany, Innis, & Duboule, ).…”

Section: Discussionmentioning

confidence: 54%

Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses

Zhang

Yang

zhang

et al. 2019

J of Neuroscience Research

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The relationships of digit ratio (2D:4D) with the length of AR (CAG)n, and testosterone levels from saliva and blood have been extensively debated over the years. This research including three studies further clarifies such controversies. To do so, we re‐examined the relationships between the length of AR (CAG)n, 2D:4D, and current testosterone levels, through replication study and meta‐analysis for each study. The results indicate: (a) the length of AR (CAG)n is not significantly associated with 2D:4D; (b) current testosterone levels are not significantly associated with the ratio; and (c) the length is not significantly associated with testosterone levels. Thus, AR (CAG)n and current testosterone levels are not significantly related to 2D:4D at individual level.

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Section: Discussionmentioning

confidence: 54%

Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses

Zhang

Yang

zhang

et al. 2019

J of Neuroscience Research

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“…between digit ratios of children and those of their mothers, whereas previous studies (e.g. Hiraishi, Sasaki, Shikishima, & Ando, 2012;Kalichman, Batsevich, & Kobyliansky, 2019;Voracek & Dressler, 2009) suggest that genetic factors contribute substantially to the phenotypic expression of this trait.…”

Section: Comparisons Of 2d:4d Between Patients With Cah and Controlsmentioning

confidence: 67%

Digit ratio (2D:4D) and congenital adrenal hyperplasia (CAH): Systematic literature review and meta-analysis

Richards

Browne

Aydin

et al. 2020

Hormones and Behavior

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The ratio of length between the second and fourth fingers (2D:4D) is commonly used as an indicator of prenatal sex hormone exposure. Several approaches have been used to try to validate the measure, including examining 2D:4D in people with congenital adrenal hyperplasia (CAH), a suite of conditions characterised by elevated adrenal androgen production secondary to defective steroidogenesis. We present here a systematic review that examines the relationship between these two variables. Twelve articles relating to nine CAH cohorts were identified, and 2D:4D comparisons have been made between cases and controls in eight of these cohorts. Altogether, at least one 2D:4D variable has been compared between n=251 females with CAH and n=358 unaffected females, and between n=108 males with CAH and n=204 unaffected males. A previous meta-analysis (Hönekopp & Watson, 2010) reported lower right hand (R2D:4D) and left hand (L2D:4D) digit ratios in patients with CAH relative to sexmatched controls. Our meta-analysis showed the same direction of results; however, the effects were only statistically significant for R2D:4D in males and L2D:4D in females (R2D:4D: females, p = 0.072, g = 0.591; males, p = 0.019, g = 0.513; L2D:4D: females, p = 0.020, g = 0.245; males, p = 0.334, g = 0.218), and the average effect size had reduced by 46.70%. We also found no evidence to suggest the right-left difference in 2D:4D (D[R-L]) is associated with prenatal sex hormone exposure.

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“…(e.g Hiraishi, Sasaki, Shikishima, & Ando, 2012;Kalichman, Batsevich, & Kobyliansky, 2019;Voracek & Dressler, 2009Rivas et al (2014), who reported L2D:4D in males with CAH to be higher than that of male controls.…”

mentioning

confidence: 99%

Digit ratio (2D:4D) and Congenital Adrenal Hyperplasia (CAH): Systematic Literature Review and Meta-Analysis

Richards¹,

Browne

Aydin³

et al. 2020

Preprint

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The ratio of length between the second and fourth fingers (2D:4D) is commonly used as an indicator of prenatal sex hormone exposure. Several approaches have been used to try to validate the measure, including examining 2D:4D in people with congenital adrenal hyperplasia (CAH), a suite of conditions characterised by elevated adrenal androgen production secondary to defective steroidogenesis. We present here a systematic review that examines the relationship between these two variables. Twelve articles relating to nine CAH cohorts were identified, and 2D:4D comparisons have been made between cases and controls in eight of these cohorts. Altogether, at least one 2D:4D variable has been compared between n=251 females with CAH and n=358 unaffected females, and between n=108 males with CAH and n=204 unaffected males. A previous meta-analysis (Hönekopp & Watson, 2010) reported lower right hand (R2D:4D) and left hand (L2D:4D) digit ratios in patients with CAH relative to sex-matched controls. Our meta-analysis showed the same direction of results; however, the effects were only statistically significant for R2D:4D in males and L2D:4D in females (R2D:4D: females, p = 0.072, g = 0.591; males, p = 0.019, g = 0.513; L2D:4D: females, p = 0.020, g = 0.245; males, p = 0.334, g = 0.218), and the average effect size had reduced by 46.70%. We also found no evidence to suggest the right-left difference in 2D:4D (D[R-L]) is associated with prenatal sex hormone exposure.

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Heritability estimation of 2D:4D finger ratio in a Chuvashian population‐based sample

Cited by 14 publications

References 36 publications

Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses

Revisiting the relationships of 2D:4D with androgen receptor (AR) gene and current testosterone levels: Replication study and meta‐analyses

Digit ratio (2D:4D) and congenital adrenal hyperplasia (CAH): Systematic literature review and meta-analysis

Digit ratio (2D:4D) and Congenital Adrenal Hyperplasia (CAH): Systematic Literature Review and Meta-Analysis

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