Heritabilities and Genetic Correlations of Body Composition and  Structural Soundness Traits in Commercial Gilts

Nikkilä, Marja; Stalder, Kenneth J.; Mote, Benny E; Lampe, Jay; Thorn, Bridget; Rothschild, Max F.; Johnson, Anna K.; Karriker, Locke A.; Serenius, Timo

doi:10.31274/ans_air-180814-147

Cited by 6 publications

(11 citation statements)

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“…Thus, IGFBP3 transcription factors involved in the regulation of fat deposition may also function in the transcriptional activation of leg The South African Journal of Animal Science is available online at http://www.sasas.co.za/sajas.asp South African Journal of Animal Science 2009, 39 (2) © South African Society for Animal Science 129 soundness. Although this association was indicative in this study, it is in agreement with previous findings that the genetic correlations between leg action and fat deposition measurements are antagonistic in pigs (Huang et al, 1995;Jørgensen & Andersen, 2000;Nikkilä et al, 2008). On the other hand, the association between the favourable alleles for both leg action and fatness in HMGA1 and TCF7L2 (T and G, respectively) suggests that for these genes less fatness may be associated with better leg soundness.…”

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confidence: 92%

“…In Denmark, up to 72% of culls were attributed to locomotive system problems (Kirk et al, 2005). Genetic improvement for leg action traits has in the past been challenging, since these traits have been shown to exhibit low to moderate heritability (Webb et al, 1983;Huang et al, 1995;Jørgensen & Andersen, 2000;Nikkilä et al, 2008). High fat deposition in pigs has been found to be associated with low lean meat production (Chen et al, 2002).…”

mentioning

confidence: 99%

“…Genetic progress for reduced fatness, using traditional breeding methods has been successful. Conversely, selection for reduced fatness has been shown to have antagonistic relationships with leg action traits (Huang et al, 1995;Stern et al, 1995;Jørgensen & Andersen, 2000;Nikkilä et al, 2008). Marker assisted selection (MAS) may be an effective strategy in improving these traits of economic importance and at the same time overcome pleoitropic effects in genes.…”

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Investigation of effects of three candidate genes on leg action and fat deposition traits in pigs (Short communication)

Makgahlela¹,

Fan²,

Du³

et al. 2009

SA J. An. Sci.

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Data from 188 sows were used in the current study to examine the effects of high mobility group AT-hook1 (HMGA1), transcription factor 7-like-2 (TCF7L2) and insulin-like growth factor binding protein 3 (IGFBP3) genes on leg action and fat deposition traits, and further to explore the possible relationships between these genes on both traits. The candidate genes used in the study are known for their roles in fat deposition and growth. Overall leg action was scored on a scale of 1 (good movement) to 9 (leg weakness). Fatness traits included 10 th rib backfat (BF10), adjusted 10 th rib backfat to 125 kg (adjBF10) and last rib backfat (last BF), measured by ultrasonic imaging approach. The association analyses between single nucleotide polymorphisms (SNPs) and traits were performed using PROC MIXED procedures of SAS. The results showed that the associations between HMGA1, TCF7L2 and IGFBP3 genotypes with fat deposition traits were mostly suggestive in this limited data set. Leg action was also suggestively associated with IGFBP3 gene effects but was not associated with HMGA1 and TCF7L2 genes. Thus, IGFBP3 AA homozygote individuals tended to have had better movements (5.40), and were fatter when compared to GG homozygotes (5.84). The results from this study suggest a possible association between the IGFBP3 gene effects on both leg action and fatness. Therefore, further studies must be carried out in several populations, and using larger data to demonstrate these results conclusively.

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confidence: 92%

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confidence: 99%

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Investigation of effects of three candidate genes on leg action and fat deposition traits in pigs (Short communication)

Makgahlela¹,

Fan²,

Du³

et al. 2009

SA J. An. Sci.

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“…The allele T of SNP INRA0052808 located in BMP2 was associated with long body length, shallow body depth and narrow body width, and additionally it was associated with upright front/rear leg pastern postures and smaller LMA (Table 1). The genetic correlation between body length and body depth was positive while it was negative between these two traits and body width, and body width had a high favorable genetic correlation with LMA [26]. In practical breeding programs, animals could be selected as breeding stock based on the allele in BMP preferred by the breeder based on structural requirement.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Study Identifies Loci for Body Composition and Structural Soundness Traits in Pigs

et al. 2011

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BackgroundThe recent completion of the swine genome sequencing project and development of a high density porcine SNP array has made genome-wide association (GWA) studies feasible in pigs.Methodology/Principal FindingsUsing Illumina's PorcineSNP60 BeadChip, we performed a pilot GWA study in 820 commercial female pigs phenotyped for backfat, loin muscle area, body conformation in addition to feet and leg (FL) structural soundness traits. A total of 51,385 SNPs were jointly fitted using Bayesian techniques as random effects in a mixture model that assumed a known large proportion (99.5%) of SNPs had zero effect. SNP annotations were implemented through the Sus scrofa Build 9 available from pig Ensembl. We discovered a number of candidate chromosomal regions, and some of them corresponded to QTL regions previously reported. We not only have identified some well-known candidate genes for the traits of interest, such as MC4R (for backfat) and IGF2 (for loin muscle area), but also obtained novel promising genes, including CHCHD3 (for backfat), BMP2 (for loin muscle area, body size and several FL structure traits), and some HOXA family genes (for overall leg action). The candidate regions responsible for body conformation and FL structure soundness did not overlap greatly which implied that these traits were controlled by different genes. Functional clustering analyses classified the genes into categories related to bone and cartilage development, muscle growth and development or the insulin pathway suggesting the traits are regulated by common pathways or gene networks that exert roles at different spatial and temporal stages.Conclusions/SignificanceThis study is one of the earliest GWA reports on important quantitative traits in pigs, and the findings will contribute to the further biological function analysis of the identified candidate genes and potential utilization of them in marker assisted selection.

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“…Since the start of pig breeding, a subjective assessment of exterior traits has been carried out by the breeders, and several evaluation systems have been implemented by pig breeders and pig breeding companies worldwide (Bereskin, 1979;Lundeheim, 1987;Grindflek and Sehested, 1996;Nikkilä et al, 2013a). The focus on exterior traits in the pig industry is primarily owing to its relationship with leg weakness and the stayability of the animals.…”

Section: Introductionmentioning

confidence: 99%

Genetic trends of conformation traits and genetic correlations to osteochondrosis in boars

Aasmundstad

Gjerlaug-Enger

Grindflek

et al. 2014

animal

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The objective of our study was to investigate the heritabilities and genetic correlations between traits from a linear exterior assessment system and osteochondrosis (OC) measured by computed tomography (CT), and in addition, to study the genetic trend in a population where the conformation traits have been included in the breeding goal. The data material consisted of phenotypes from a total of 4571 Norsvin Landrace test boars. At the end of the test period, all boars were subjected to a detailed exterior assessment system. Within 10 days of the assessment, the boars were CT scanned for measuring OC. The total score of osteochondrosis (OCT), used in this study, is the sum of phenotypes from the assessment on the medial and lateral condyles at the distal end of both the humerus and the femur of the right and the left leg of the boar based on images from CT. The exterior assessment traits included in the study were; 'front leg knee' (FKNE), 'front leg pasterns' (FPAS), 'front leg stance' (FSTA), 'front leg twisted pasterns' (FFLK), 'hind leg stance', 'hind leg pasterns' (HPAS), 'hind leg standing under' (HSTU), 'hind leg small inner toe', 'dipped back', 'arched back' (ARCH) and 'waddling hindquarters' (WADL). The estimation of (co)variance components and breeding values were performed using bivariate animal genetic models. Breeding values for HSTU, HPAS, FPAS, WADL and OCT traits were additional outputs from the same bivariate analyses. The lowest heritability was found for FFLK ( h 2 FFLK = 0.05), whereas FPAS was estimated to have the highest heritability ( h 2 FPAS = 0.36), and OCT demonstrating a heritability of 0.29. Significant genetic correlations were found between several traits; the strongest correlation was between FSTA and FFLK (0.94), which was followed by the correlation between FPAS and FKNE (0.69). The traits ARCH and FSTA had significant genetic correlations to OCT, whereas all other genetic correlations between OCT and the conformation traits were low and not significantly different from 0. Our study shows positive genetic trends for the conformation traits included in the breeding goal. In general, low genetic correlations between conformation traits and OC were observed in our study.

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Heritabilities and Genetic Correlations of Body Composition and Structural Soundness Traits in Commercial Gilts

Cited by 6 publications

References 0 publications

Investigation of effects of three candidate genes on leg action and fat deposition traits in pigs (Short communication)

Investigation of effects of three candidate genes on leg action and fat deposition traits in pigs (Short communication)

Genome-Wide Association Study Identifies Loci for Body Composition and Structural Soundness Traits in Pigs

Genetic trends of conformation traits and genetic correlations to osteochondrosis in boars

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