Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin

Buta, Corina; Benabou, Eva; Lequoy, Marie; Regnault, Hélène; Wendum, Dominique; Meratbene, Fatiha; Chettouh, Hamza; Aoudjehane, Lynda; Conti, Filoména; Chrétien, Yves; Scatton, Olivier; Rosmorduc, Olivier; Praz, Françoise; Fartoux, Lætitia; Desbois-Mouthon, Christèle

doi:10.1186/s13046-016-0402-3

Cited by 9 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In support of this, we detected the presence of ErbB2 mRNA in human neutrophils by RT-PCR (Figure 4A) and a 60kD protein (lower molecular weight ErbB family products are well-documented (Jackson et al, 2013; Guillaudeau et al, 2012; Siegel, 1999; Ward et al, 2013) which was upregulated by GMCSF and dbcAMP (Figure 4B). ErbB3 was also detected in human neutrophils by ELISA (Figure 4C), at levels similar to those observed in other tissues in literature (Buta et al, 2016). We found ErbB3 expression was not regulated by growth factors, which may in part be due to regulation being primarily at the post-translational level.…”

Section: Resultssupporting

confidence: 87%

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Rahman

Henry

Herman

et al. 2019

eLife

View full text Add to dashboard Cite

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering mechanisms regulating neutrophil survival is likely to identify novel therapeutic targets. Screening of 367 kinase inhibitors in human neutrophils and a zebrafish tail fin injury model identified ErbBs as common targets of compounds that accelerated inflammation resolution. The ErbB inhibitors gefitinib, CP-724714, erbstatin and tyrphostin AG825 significantly accelerated apoptosis of human neutrophils, including neutrophils from people with COPD. Neutrophil apoptosis was also increased in Tyrphostin AG825 treated-zebrafish in vivo. Tyrphostin AG825 decreased peritoneal inflammation in zymosan-treated mice, and increased lung neutrophil apoptosis and macrophage efferocytosis in a murine acute lung injury model. Tyrphostin AG825 and knockdown of egfra and erbb2 by CRISPR/Cas9 reduced inflammation in zebrafish. Our work shows that inhibitors of ErbB kinases have therapeutic potential in neutrophilic inflammatory disease.

show abstract

Section: Resultssupporting

confidence: 87%

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Rahman

Henry

Herman

et al. 2019

eLife

View full text Add to dashboard Cite

show abstract

“…Firstly, our study was performed on patients of Caucasian ethnicity chronically infected with HCV, while the study by Hsieh et al included Asian patients prevalently infected with hepatitis B virus; in fact, previous reports showed that etiology of chronic liver disease could affect the performance of HCC biomarkers [ 24 ]. In addition, this is in good agreement with the results of a recent study showing that HBV and HCV infections were associated with different ERBB3 mRNA expression in HCC cells [ 25 ]. Regarding ethnicity, several studies showed that ethnic differences may influence cancer biomarker levels as well as drug response and survival, possibly reflecting different genetic alterations and epigenetic changes involved in the regulation of oncogenic pathways [ 26 ].…”

Section: Discussionsupporting

confidence: 92%

The Clinical Role of Serum Epidermal Growth Factor Receptor 3 in Hepatitis C Virus-Infected Patients with Early Hepatocellular Carcinoma

Caviglia

Abate

Rolle³

et al. 2021

Biology

View full text Add to dashboard Cite

Epidermal growth factor receptor 3 (ERBB3) is a surface tyrosine kinase receptor belonging to the EGFR/ERBB family, involved in tumor development and progression. We evaluated the diagnostic and prognostic value of serum ERBB3 measurement in hepatitis C virus (HCV)-infected patients with early hepatocellular carcinoma (HCC). A total of 164 HCV-infected patients (82 with cirrhosis and 82 with early HCC) were included in the study. HCC was classified according to the Barcelona Clinic Liver Cancer (BCLC) staging system. Among patients with HCC, 23 (28%) had a diagnosis of very early tumor (BCLC = 0), while 59 (62%) had a diagnosis of early HCC (BCLC = A). Median overall survival (OS) in patients with HCC was 79.2 (95% CI 51.6–124.8) months. While ERBB3 serum values were similar between patients with cirrhosis and those with HCC (p = 0.993), in the latter, serum ERBB3 ≥ 2860 RU resulted significantly and independently associated with OS (Hazard Ratio = 2.24, 95% CI 1.16–4.35, p = 0.017). Consistently, the 1-, 3-, and 5-year OS rates in patients with serum ERBB3 ≥ 2860 RU were 90% (36/40), 53% (19/36), and 28% (8/29) in comparison to patients with serum ERBB3 < 2860 RU, which were 98% (40/41), 80% (32/40), and 74% (26/35) (Log-rank test; p = 0.014). In conclusion, serum ERBB3 values resulted an independent prognostic factor of patients with early HCC and might be useful to tailor more personalized treatment strategies.

show abstract

“…GPC3 promotes cancerogenesis via activation of the Wnt/β-catenin signaling pathway and, hence, presents itself as a potential therapeutic target (Kolluri and Ho, 2019; Shih et al, 2020). Finally, another noteworthy receptor from the list is ERBB3 (HERT3) which is upregulated in chronic hepatitis B (CHB) but not hepatitis C induced HCC (Buta et al, 2016) corresponding to the liquid biopsy liver cancer sample composition we employed (>60% CHB) (Chen et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

Detection of reproducible liver cancer specific ligand-receptor signaling in blood

Safrastyan,

Wollny

2023

Preprint

View full text Add to dashboard Cite

Cell-cell communication mediated by ligand-receptor interactions (LRI) is critical to coordinating diverse biological processes in homeostasis and disease. Lately, our understanding of these processes has greatly expanded through the inference of cellular communication, utilizing RNA extracted from bulk tissue or individual cells. Considering the challenge of obtaining tissue biopsies for these approaches, we considered the potential of studying cell-free RNA obtained from blood. To test the feasibility of this approach, we used the BulkSignalR algorithm across 295 cell-free RNA samples and compared the LRI profiles across multiple cancer types and healthy donors. Interestingly, we detected specific and reproducible LRIs particularly in the blood of liver cancer patients compared to healthy donors. We found an increase in the magnitude of hepatocyte interactions, notably hepatocyte autocrine interactions in liver cancer patients. Additionally, a robust panel of 30 liver cancer-specific LRIs presents a bridge linking liver cancer pathogenesis to discernible blood markers. In summary, our approach shows the plausibility of detecting liver LRIs in blood and builds upon the biological understanding of cell-free transcriptomes.

show abstract

Heregulin-1ß and HER3 in hepatocellular carcinoma: status and regulation by insulin

Cited by 9 publications

References 39 publications

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

The Clinical Role of Serum Epidermal Growth Factor Receptor 3 in Hepatitis C Virus-Infected Patients with Early Hepatocellular Carcinoma

Detection of reproducible liver cancer specific ligand-receptor signaling in blood

Contact Info

Product

Resources

About