Heredity and Self-Organization: Partners in the Generation and Evolution of Phenotypes

Malagon, Nicolas; Larsen, Ellen

doi:10.1016/bs.ircmb.2014.12.003

Cited by 5 publications

(4 citation statements)

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“…As the SC rotates during development, pronounced changes in apical cell area take place between the initial and final stages of sex comb rotation, while during these same stages epithelial cell division is conspicuously absent [ 15 , 16 , 27 , 28 ]. Based on the temporal variation in cell parameters in which epithelial cells from the distal region increase in size but cells from the proximal region decrease in size, at least three hypothetical models can be envisioned: pull, push, and push and pull [ 15 ] ( Fig 1C ).…”

Section: Resultsmentioning

confidence: 99%

“…Possibly, the most interesting comb feature involves its orientation [ 9 ], which constantly changes between three positions relative to joint: transverse, diagonal, and vertical ( Fig 1D ). Malagon and Larsen [ 16 ] suggest that genetic perturbations in D. melanogaster can easily phenocopy changes in comb variation. Thus, the SC system provides a rich developmental and evolutionary phenomenology with which to explore the strategies and tactics involved in morphogenesis and its evolution.…”

Section: Introductionmentioning

confidence: 99%

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Rotation of sex combs in Drosophila melanogaster requires precise and coordinated spatio-temporal dynamics from forces generated by epithelial cells

Malagon

Ahuja

et al. 2018

PLoS Comput Biol

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The morphogenesis of sex combs (SCs), a male trait in many species of fruit flies, is an excellent system in which to study the cell biology, genetics and evolution of a trait. In Drosophila melanogaster, where the incipient SC rotates from horizontal to a vertical position, three signal comb properties have been documented: length, final angle and shape (linearity). During SC rotation, in which many cellular processes are occurring both spatially and temporally, it is difficult to distinguish which processes are crucial for which attributes of the comb. We have used a novel approach combining simulations and experiments to uncover the spatio-temporal dynamics underlying SC rotation. Our results indicate that 1) the final SC shape is primarily controlled by the inhomogeneity of initial cell size in cells close to the immature comb, 2) the final angle is primarily controlled by later cell expansion and 3) a temporal sequence of cell expansion mitigates the malformations generally associated with longer rotated SCs. Overall, our work has linked together the morphological diversity of SCs and the cellular dynamics behind such diversity, thus providing important insights on how evolution may affect SC development via the behaviours of surrounding epithelial cells.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rotation of sex combs in Drosophila melanogaster requires precise and coordinated spatio-temporal dynamics from forces generated by epithelial cells

Malagon

Ahuja

et al. 2018

PLoS Comput Biol

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“…These complex interactions between developmental processes can explain some biases in phenotypic variation (Brakefield, 2006;de Bakker et al, 2013;Malagón et al, 2014). Finally, although this work concentrated on how body scale proportions change over time, we consider that the entrenchment of developmental processes described in this work, can be an important feature for understanding how some phenotypes originate and evolve (Malagon and Larsen, 2015).…”

Section: Discussionmentioning

confidence: 99%

Evolution of allometric changes in fruit fly legs: a developmentally entrenched story

Malagon¹,

Khan

2016

Acta biol. Colomb.

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La evolución de los cambios alométricos en las patas de las moscas de la fruta: una historia enraizada en la biología del desarrollo ABSTRACTAllometric studies measure the scaling changes between different body parts and these often have implications on understanding ecology and evolution. Although most work on allometry has described its importance during phenotypic evolution, few studies have focused on studying how entrenched developmental processes can affect allometric changes. To explore this problem, here we used the sex comb, a male-specific group of bristles with a spectacular morphological diversity among Drosophila species. By combining morphometric analysis in wild type and genetically perturbed Drosophila melanogaster and Drosophila species, we studied the allometric changes that occur in leg length and other bristle rows in concert with sex comb radiation. We show that bristledevelopmental processes are important for understanding the allometric changes of Drosophila first tarsal segments. Different lines of evidence suggest that a complicated interaction between bristle spacing and movement are crucial for understanding the evolution of allometry in this system. As a result, this work shows that although the emergence of a new trait, the sex comb, can modify the allometric relationships, there is a hierarchy of ancestral developmental processes with respect to how easily they can be modified. As a result, the interconnection of developmental processes can bias the direction of morphological changes.Keywords: rotation, sex combs, transverse rows. RESUMENLa alometría estudia los cambios de tamaño entre las diferentes partes del cuerpo de los seres vivos y sus implicaciones ecológicas y evolutivas. Aunque la mayoría de los estudios en esta área se han centrado en investigar la importancia de los cambios alométricos en la evolución fenótipica, pocos estudios han analizado como la interconexión de los diferentes procesos del desarrollo afectan dichos cambios de tamaño. Para investigar la relación entre los mecanismos de desarrollo y los cambios alométricos, utilizamos los peines sexuales de diferentes especies del género Drosophila. Dichas estructuras, constituidas por un grupo de sedas ubicadas en las patas anteriores de los machos, presentan una variedad morfológica sobresaliente durante la evolución. Por medio de análisis morfométricos entre diferentes especies de Drosophila, incluidas líneas de Drosophila melanogaster modificadas genéticamente, investigamos los cambios alométricos que ocurren en el tamaño de las patas y diferentes tipos de sedas como resultado de la radiación de los peines sexuales. En este trabajo presentamos evidencia que sugiere una interacción compleja entre los mecanismos del desarrollo encargados de definir la distancia entre las sedas y su movimiento. Además, mostramos que dichos mecanismos son fundamentales para entender cómo evoluciona la alometría en los segmentos tarsales. Aunque la emergencia de una nueva característica puede modificar las relaciones alométricas, los p...

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“…As for laboratory investigation, it should be conducted in all suspected situations of this disease, using the functional quantification of coagulation inhibitors [antithrombin (AT), protein C (PC), protein S (PS)], the plasma homocysteine quantification, mutations research (FVL and FIIG20210A) and the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin IgM and IgG) [12] . Thus, it is essential to select patients for thrombophilia screening in a detailed anamnesis on the type and context of thromboembolic events in the family history evaluation since hereditary thrombophilias are autosomal dominant transmission [13] .…”

Section: Disease Diagnosismentioning

confidence: 99%

Gestational Thrombophilia

Casseb¹,

Casseb²,

Souza³

et al. 2022

Int J Innov Educ Res

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The woman's body undergoes several physiological changes during the gestational period. Risk factors and comorbidities can cause pathophysiological changes in this period, especially in the maternal vascular system, triggering thrombophilia. This clotting disorder increases the thrombus formation risk, especially in the uteroplacental circulation. The study aimed to conduct a thorough review of the main approaches to diagnosis and treatment in reducing patient morbidity and mortality. This is an integrative review with qualitative data searched in Pubmed, BVS and Cochrane Library. A total of 624 studies were found, 591 were excluded outside the inclusion criteria, and 33 were selected. According to the careful search, thrombophilias can be hereditary or acquired, the former when there is a predisposition to venous occlusion and the latter from other clinical conditions. Pregnancy is a pro-thrombotic event and increases the chances of thrombus occurrence, triggering a series of pregnancy complications, such as intrauterine death, early or late miscarriage, and premature birth. However, if diagnosed early, there is a favorable prognosis for the woman and the fetus. To reduce these impacts of gestational thrombophilia, it is imperative to train primary health care and private clinics professionals to promote and treat health and basic diagnostic tests on pregnant women. Thus, performing early intervention avoiding the development of maternal-fetal complications.

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Heredity and Self-Organization: Partners in the Generation and Evolution of Phenotypes

Cited by 5 publications

References 87 publications

Rotation of sex combs in Drosophila melanogaster requires precise and coordinated spatio-temporal dynamics from forces generated by epithelial cells

Rotation of sex combs in Drosophila melanogaster requires precise and coordinated spatio-temporal dynamics from forces generated by epithelial cells

Evolution of allometric changes in fruit fly legs: a developmentally entrenched story

Gestational Thrombophilia

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