Heredity and Psoriasis

Abele, Donald C.

doi:10.1001/archderm.1963.01590190044005

Cited by 77 publications

(8 citation statements)

References 18 publications

(1 reference statement)

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“…Moreover, a significantly higher incidence of the disease is observed among patients’ relatives [ 17 ]. The assessment of the sera of 346 subjects from a kindred of 815 Caucasian Americans spanning six generations has highlighted the implication of genetic factors [ 18 ]. Although psoriasis can affect people of all ages, there is a bimodal age of onset: early-onset occurs before 40 years old and represents 75% of the cases, while the late-onset occurs at a mean age of 56–60 years [ 19 , 20 ].…”

Section: The Genetic Basis Of Psoriasismentioning

confidence: 99%

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis

Rioux

Ridha

Simard

et al. 2020

Genes

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Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology involving environmental and genetic factors. A better insight into related genomic alteration helps design precise therapies leading to better treatment outcome. Gene expression in psoriasis can provide relevant information about the altered expression of mRNA transcripts, thus giving new insights into the disease onset. Techniques for transcriptome analyses, such as microarray and RNA sequencing (RNA-seq), are relevant tools for the discovery of new biomarkers as well as new therapeutic targets. This review summarizes the findings related to the contribution of keratinocytes in the pathogenesis of psoriasis by an in-depth review of studies that have examined psoriatic transcriptomes in the past years. It also provides valuable information on reconstructed 3D psoriatic skin models using cells isolated from psoriatic patients for transcriptomic studies.

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Section: The Genetic Basis Of Psoriasismentioning

confidence: 99%

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis

Rioux

Ridha

Simard

et al. 2020

Genes

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“…Though ample evidence in favour of this view has been presented in roentgenological (e. g. Avila et al 1960) and serological (e. g. Reed et al 1961a) studies, the problem has not yet been definitely settled (d. Abele et al 1963),…”

mentioning

confidence: 99%

Psoriasis Arthropathy and Rheumatoid Arthritis: A Roentgenological Comparison

Lassus¹,

Mustakallio²,

Laine³

1964

Acta Rheumatologica Scandinavica

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“…It is also conceivable that patients with psoriasis and arthritis have a different disease from patients with psoriasis alone. The question of heterogeneity in psoriasis has been raised in the past (Abele, Dobson, and Graham, 1963). Steinberg, Becker, Fitzpatrick, and Kierland (1951) deduced from their studies that at least two genes would be required to explain the familial distribution of psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Distal interphalangeal joint disease and nail abnormalities.

Green¹

1968

Annals of the Rheumatic Diseases

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Heredity and Psoriasis

Cited by 77 publications

References 18 publications

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis

Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis

Psoriasis Arthropathy and Rheumatoid Arthritis: A Roentgenological Comparison

Distal interphalangeal joint disease and nail abnormalities.

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