Hereditary skeletal muscle diseases in the horse. A review

Nollet, Heidi; Deprez, Piet

doi:10.1080/01652176.2005.9695187

Cited by 12 publications

(7 citation statements)

References 72 publications

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“…28 Severe degenerative myopathy in equids can be fatal. 17,19,25,31,32,35 Causes of muscular disorders in adult horses include nutritional myopathy, 5,17,31 infectious disease, 10,17,32,35,38 immune-mediated disorders, 17,25,26 toxic myopathy, 19,36 inherited myopathies, 5,29 endocrinopathy, 2 pasture-associated rhabdomyolysis, 15,44,45 malignant hyperthermia, 1 and exertional rhabdomyolysis. 4,6,23,39 Disorders affecting the peripheral nerves resulting in denervation atrophy of muscle also occur.…”

Section: Introductionmentioning

confidence: 99%

Pathologic Findings in Equine Muscle (Excluding Polysaccharide Storage): A Necropsy Study

Valentine

2008

J VET Diagn Invest

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Abstract. Gross and histopathologic evaluation of skeletal muscle was performed in 229 equids (217 horses, 8 ponies, 3 donkeys, and 1 mule) 1 year of age or older undergoing postmortem examination at Oregon State University in a 2.5-year period. Animals were evaluated for grossly evident muscle lesions, and muscle samples were fixed in formalin, processed routinely, and stained with hematoxylin and eosin (HE) and periodic acid-Schiff (PAS) for glycogen. Muscle lesions were detected in 149 animals (65%). Chronic myopathic change (excessive fiber size variation and internal nuclei) was evaluated in horses without polysaccharide storage myopathy and was the most common finding (36 animals; 15.7%). Chronic myopathic change was more common in older animals. Generalized muscle atrophy was present in 30 animals (13.1%). Myonecrosis was attributed to endotoxic injury (11 animals; 4.8%), bone fracture (8 animals; 3.5%), bacterial infection (5 animals; 2.2%), muscle rupture (3 animals; 1.3%), selenium deficiency (2 animals; 0.9%), and exertional rhabdomyolysis (1 horse; 0.4%); cause was not determined in 9 animals (3.9%). Intramyofiber protozoa were detected in 19 horses and ponies (8.3%). Denervation atrophy was detected in 14 animals (6.1%). Neoplasia involving muscle occurred in 3 animals (1.3%), injection site reactions were detected in 4 animals (1.7%), and focal lymphocytic infiltrates were found in 6 animals (2.6%). Other findings were ring fibers (2 horses; 0.9%), fiber splitting (2 horses; 0.9%), and fat infiltration (1 horse; 0.4%). Skeletal muscle lesions are common in equids examined at postmortem. Transverse sections stained with HE and PAS are invaluable when evaluating equine muscle.

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Section: Introductionmentioning

confidence: 99%

Pathologic Findings in Equine Muscle (Excluding Polysaccharide Storage): A Necropsy Study

Valentine

2008

J VET Diagn Invest

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“…Symptoms are mild hind end stiffness, gait abnormalities, bulging of thigh and rump muscles and contraction (muscle dimpling) of affected muscles after being stimulated by percussion for up to a minute (51). The symptoms get worse following a period of rest (36). There is no significant and sustained elevation in CK and AST activities.…”

Section: Mitochondrial Myopathiesmentioning

confidence: 95%

“…There is no significant and sustained elevation in CK and AST activities. Elevations are only seen especially after stress due to transportation or intramuscular injections (36 6. Secondary (or acquired) metabolic myopathies There is a group of secondary or acquired metabolic myopathies with a wide variation of diseases resulting in myopathies which will not be discussed here.…”

Section: Mitochondrial Myopathiesmentioning

confidence: 99%

“…Maybe in the future this will also be applicable to horses, since the complete equine mitochondrial DNA sequence is available now (36,77 Myotonia, rare in the horse, is characterized by contraction and difficulty in relaxation of muscle following stimulation (50). The biochemical defects responsible for the condition are not known explicitly, but seem to be inherent within the muscle rather than the nervous system, maybe involving the chloride channels.…”

Section: Mitochondrial Myopathiesmentioning

confidence: 99%

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Equine metabolic myopathies with emphasis on the diagnostic approach comparison with human myopathies A review

Westermann¹,

Dorland

Wijnberg

et al. 2007

Veterinary Quarterly

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“…In a case study of a New Forest pony, Wijinberg et al (2012) reported a missense mutation in the CLCN1 gene that was associated with a phenotype of hereditary recessive myotonia. According to Nollet and Deprez (2005), horses with this syndrome show gait abnormalities and stiffness after birth and these symptoms get worse after a period of rest.…”

Section: Genomic Regions Selected In Quarter Horsesmentioning

confidence: 99%

Prospection of genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line

Meira

Curi

Farah

et al. 2014

Animal

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Selection of Quarter Horses for different purposes has led to the formation of lines, including racing and cutting horses. The objective of this study was to identify genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line applying relative extended haplotype homozygosity (REHH) analysis, an extension of extended haplotype homozygosity (EHH) analysis, and the fixation index ( F ST ) statistic. A total of 188 horses of both sexes, born between 1985 and 2009 and registered at the Brazilian Association of Quarter Horse Breeders, including 120 of the racing line and 68 of the cutting line, were genotyped using single nucleotide polymorphism arrays. On the basis of 27 genomic regions identified as selection signatures by REHH and F ST statistics, functional annotations of genes were made in order to identify those that could have been important during formation of the racing line and that could be used subsequently for the development of selection tools. Genes involved in muscle growth (n = 8), skeletal growth (n = 10), muscle energy metabolism (n = 15), cardiovascular system (n = 14) and nervous system (n = 23) were identified, including the FKTN, INSR, GYS1, CLCN1, MYLK, SYK, ANG, CNTFR and HTR2B.

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Hereditary skeletal muscle diseases in the horse. A review

Cited by 12 publications

References 72 publications

Pathologic Findings in Equine Muscle (Excluding Polysaccharide Storage): A Necropsy Study

Pathologic Findings in Equine Muscle (Excluding Polysaccharide Storage): A Necropsy Study

Equine metabolic myopathies with emphasis on the diagnostic approach comparison with human myopathies A review

Prospection of genomic regions divergently selected in racing line of Quarter Horses in relation to cutting line

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