Hereditary Persistence of Fetal Hemoglobin

Huisman, T. H. J.; Schroeder, W. A.; Charache, Samuel; Bethlenfalvay, Nicholas C.; Bouver, Nicole; Shelton, J. R.; Shelton, J. C.; Apell, Gerald

doi:10.1056/nejm197109232851303

Cited by 51 publications

(9 citation statements)

References 14 publications

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“…Two groups were observed: One group of four averaged 31% Tychain, and the remaining 39 averaged 18% (17% for 23 Black babies and 19% for 16 Caucasian newbom). 10 Veddoid Indians, and 1 Israeli citizen) has been examined; 7 from Blacks and 0 from Veddoid Indians were positive for the Ty-chain (Tables II and III). All information on the seven positive cases is detailed in Table IV (Table V).…”

Section: Resultsmentioning

confidence: 99%

“…These results do not exclude the presence of a Ty-gene in trans to the HPFH determinant in the heterozygote, but do suggest that it is absent in cis within the limits of this relatively small all types; two subjects were also heterozygous I Was also heterozygous for Hb-E. § See (6). I i See (7,8). ¶ See (9); two subjects were also heterozygous for Hb-S.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

Schroeder¹,

Huisman²,

Ефремов³

et al. 1979

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Further studies of the frequency and significance of the Tgamma-chain of human fetal hemoglobin.

Schroeder¹,

Huisman²,

Ефремов³

et al. 1979

J. Clin. Invest.

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“…Hematological findings including red cell morphology and levels of hemoglobin A2 (Hb A.) and hemoglobin F (Hb F) are similar in Negro and non-Negro patients with P-thalassemia trait (2)(3)(4). Homozygous fi-thalassemia in the Negro has been reported infrequently with approximately 20 cases appearing in the American literature (5).…”

Section: Introductionmentioning

confidence: 99%

β-Thalassemia in the American Negro

Friedman¹,

Rw²,

Schwartz³

1973

J. Clin. Invest.

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A B S T R A C T In Italian patients with high hemoglobinA2 fl-thalassemia trait, the synthesis of P-chains of adult hemoglobin in the peripheral blood is approximately one-half that of a-chains. In this study the relative rates of f-and a-chain synthesis were determined in 26 Negro heterozygotes and five homozygotes for fi-thalassemia in six families. The 8/a ratio of globin synthesis was decreased in only 15 heterozygotes, whereas in the other 11, fl/a globin synthesis was in the normal range or was slightly increased. These unusual findings did not appear to be due to the presence of a-thalassemia or a hyperactive "normal" fl-allele. This study demonstrates that the f8/a ratio of globin synthesis in the peripheral blood is normal in some patients with

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“…The reliability of the data has been tested repeatedly by duplicate analyses of fetal globin samples. The results indicate an order of precision and accuracy of ±0.05 residue [18,27,28,30].…”

Section: Chemical Examination Of Hb-fmentioning

confidence: 83%

“…The ratio of G y to A y chains in newborn Hb-F is about 3:1. Examination of Hb-F variants, abnormal in the y chain, and of the Hb-F from individuals with hereditary persistence of fetal hemoglobin established that the °y and A y chains are the products of nonallelic structural genes for the y chain [18][19][20]29].…”

Section: Introductionmentioning

confidence: 99%