Hereditary muscular dystrophy in MDX mice as a homologous model for introduction of cell technologies in the treatment of progressive muscular dystrophies in humans

Стенина, М. А.; Савчук, В. Й.; Sitnikov, V. F.; Krivov, L. I.; Кузнецов, А. Б.; Воеводин, Д. А.; Yarygin, V. N.; Сухих, Г. Т.

doi:10.1007/s10517-004-0030-3

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“…These mice were a part of the reproductive colony maintained at Russian State Medical University [2]. ECG in standard lead II was recorded on nonanesthesized alert animals in natural (abdominal) posture with the limbs slightly fixed to the platform.…”

Section: Methodsmentioning

confidence: 99%

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Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: Various effects of cell material

et al. 2005

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Animals with bradycardia were detected in reproductive colony of mdx mice. Low pulse rate was associated with poor survival and predisposition to sudden death, but did not directly depend on the presence of dystrophin mutant gene or animal age. Heart rate increased in old mice with bradycardia after extracardial, intramuscular, and intravenous injection of human embryonic myoblasts. Stable normalization of the pulse was observed 2 weeks after transplantation, but early peak of heart rate was observed as early as 24 h after cell transplantation. Cell suspensions, which could contain stem cells (blood mononuclears and CD34+ lymphocytes), also corrected heart rhythm. Unlike the effect of myoblasts, cardiotropic effect of mononuclears was preceded by a period of tachycardia, while the effect of CD34+ lymphocytes was very unstable. The cardiotropic effect of myoblasts was combined with life span prolongation and certain rejuvenation in some animals. Erythrocytes and supernatant obtained during blood cell fractionation did not modify the heart rhythm in mice with bradycardia. After injection of myoblasts to mice with rare and normal pulses serum creatine kinase activity decreased with different rates. These data attest to a variety of biological effects of stem cells and/or their derivatives and to ambiguous mechanisms of these effects.

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Section: Methodsmentioning

confidence: 99%

“…Activity of creatine kinase (CPK) was measured in blood samples collected from the caudal vein as described previously [2].…”

Section: Methodsmentioning

confidence: 99%

Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: Various effects of cell material

et al. 2005

Self Cite

View full text Add to dashboard Cite

show abstract

Hereditary muscular dystrophy in MDX mice as a homologous model for introduction of cell technologies in the treatment of progressive muscular dystrophies in humans

Cited by 1 publication

References 10 publications

Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: Various effects of cell material

Cardiotropic effect of extracardiac transplantation of embryonic human myoblasts to mice with bradycardia: Various effects of cell material

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