Hereditary motor–sensory neuropathy and movement disorders

Cardoso, Francisco; Jankovic, Joseph

doi:10.1002/mus.880160904

Cited by 63 publications

(33 citation statements)

References 35 publications

(1 reference statement)

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“…Given that hereditary neuropathies are considered to be clinically heterogeneous [1], polyneuropathy associated with tremor could be considered a CMT variant with central nervous system involvement in our patients [19]. In our opinion, there are 2 strong points that support this consideration.…”

Section: Discussionmentioning

confidence: 74%

“…One of the hypotheses is the presence of distorted peripheral inputs that mislead a central processor into producing tremor [7,18]. Nevertheless, not all patients with neuropathy develop tremor, and the occurrence of the tremor does not correlate with the severity of the neuropathy [19]. Some reports describe some degree of cerebellar dysfunction in neuropathic tremor similar to those described in essential tremor [20].…”

Section: Discussionmentioning

confidence: 95%

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Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease

Cabañés-Martínez

Pedro²,

Beorlegui³

et al. 2017

Stereotact Funct Neurosurg

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Background: It has been described that many Charcot-Marie-Tooth syndrome type 2 patients are affected by a very disabling type of tremor syndrome, the pathophysiology of which remains unclear. Deep brain stimulation (DBS) has been successfully applied to treat most types of tremors by implanting electrodes in the ventral intermediate nucleus of the thalamus (Vim). Methods: We used DBS applied to the Vim in 2 patients with severe axonal inherited polyneuropathies who developed a disabling tremor. Results: Both patients responded positively to stimulation, with a marked reduction of the tremor and with an improvement of their quality of life. Conclusion: We report 2 cases of tremor associated with a hereditary neuropathy with a good response to DBS.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 95%

Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease

Cabañés-Martínez

Pedro²,

Beorlegui³

et al. 2017

Stereotact Funct Neurosurg

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“…[87][88][89][90][91] Usually it is a mild postural tremor. Some cases, however, typically with chronic demyelinating peripheral neuropathies or "benign" monoclonal gammopathies ,suffer from severe and most disabling tremors.…”

Section: Tremor In Peripheral Neuropathy Diagnosismentioning

confidence: 99%

Deep brain stimulation for trauma: Patient selection and evaluation

Deuschl

Bain

2002

Mov Disord.

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The selection of patients with movement disorders for deep brain stimulation is becoming a common neurological and neurosurgical task. Deep brain stimulation is suitable for different forms of tremor, which can often not be treated with medication. This suitability applies for essential tremor, monosymptomatic tremor at rest, cerebellar or multiple sclerosis tremor, Holmes' tremor, primary writing tremor or tremor in neuropathies. The appropriate selection of patients is critical for the outcome of surgical relief of tremors. Considering the risks of any stereotactic intervention, the following must apply: (1) motor symptoms lead to a relevant disability in activities of daily living, despite optimal medical treatment; (2) biological age of the patient; (3) neurosurgical contraindications; (4) the patient is neither demented nor severely depressed. If these conditions are fulfilled, the individual chances of improvement of the target symptoms need to be checked, based on the following guidelines: (1) the kind of tremor, (2) the natural course of the tremor, (3) the chances for medical treatment in a particular patient, (4) the outcome of surgery in a specific condition, (5) the individual risks for a patient to suffer from complications. The outcome of surgery for tremor depends on the clinical type and distribution. Distal limb tremors are easier to treat than proximal limb tremors. Intention tremor is more difficult to treat than rest or postural tremor. The indication for surgical treatment depends on the analysis of the individual risk-benefit ratio, which also has to take into account the patients' social, professional, and familial background. The patient needs to be well informed about his individual risk-benefit ratio and of alternative treatments, before undergoing stereotactic surgery.

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“…While the characteristics and prevalence of tremor in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and hereditary motor-sensory neuropathies (HMSN) have been documented, 1,5 how often tremor occurs in patients with other acquired neuropathies having demyelinating features remains unclear, as does the nature of the relationship between the symptoms of neuropathy, tremor, and associated immunologic disorders. Little has been written on these topics, and virtually no in-depth physiologic studies have been performed on groups of patients with both peripheral neuropathy (PN) and tremor.…”

mentioning

confidence: 99%