Hereditary liver disease: Gallstones

Wittenburg, Henning

doi:10.1016/j.bpg.2010.07.004

Cited by 47 publications

(35 citation statements)

References 77 publications

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“…About 2-4% of asymptomatic cholecystolithiasis patients become symptomatic during follow-up annually. Risk factors for transition include multiple gallstones, negative cholecystography findings, and young age [4][5][6]. There is no clear evidence that cholecystolithiasis increases the risk of gallbladder cancer or that there is an Fig.…”

Section: Commentarymentioning

confidence: 99%

Evidence-based clinical practice guidelines for cholelithiasis 2016

Tazuma

Unno²,

Igarashi³

et al. 2016

J Gastroenterol

209

178

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Cholelithiasis is one of the commonest diseases in gastroenterology. Remarkable improvements in therapeutic modalities for cholelithiasis and its complications are evident. The Japanese Society of Gastroenterology has revised the evidence-based clinical practice guidelines for cholelithiasis. Forty-three clinical questions, for four categories-epidemiology and pathogenesis, diagnosis, treatments, and prognosis and complications-were selected, and a literature search was performed for the clinical questions with use of the MEDLINE, Cochrane, and Igaku Chuo Zasshi databases for the period between 1983 and June 2012. The guidelines were developed with use of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. This article preferentially describes the clinical management of cholelithiasis and its complications. Following description of the diagnosis performed stepwise through imaging modalities, treatments of cholecystolithiasis, choledocholithiasis, and hepatolithiasis are introduced along with a flowchart. Since there have been remarkable improvements in endoscopic treatments and surgical techniques, the guidelines ensure flexibility in choices according to the actual clinical environment. The revised clinical practice guidelines are appropriate for use by clinicians in their daily practice.

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Section: Commentarymentioning

confidence: 99%

Evidence-based clinical practice guidelines for cholelithiasis 2016

Tazuma

Unno²,

Igarashi³

et al. 2016

J Gastroenterol

209

178

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“…The four stones showed high percent of aluminum ions (0.386, 0.75, 1.17 and 1.283%, g/g) and this is unusual results because references [2][3][4][5] indicated that over the world, gallstones do not contain aluminum ions and they contain other different organic molecules or inorganic ions. In addition gallstones disease is considered to be uncommon in infants and children [6], in contrast, missan city showed that new born babies birthed with existing of stones in them gallbladder.…”

Section: Resultsmentioning

confidence: 99%

“…In general, cholesterol gallstones are distinguished from bilirubin gallstones which it forms if the ion product of unconjugated bilirubin and calcium in gallbladder bile exceeds the solubilisation capacities of mixed micelles and vesicles. Cholesterol gallstones develop if the amount of cholesterol in gallbladder bile exceeds the maximum concentration that is soluble at the given concentration of bile salts and phospholipids [3]. Cholesterol crystal nucleation is considered the earliest step in cholesterol gallstone formation.…”

Section: Introductionmentioning

confidence: 99%

Gallstones Disease 'Cholelithiasis', Reasons and Solutions

Darraji¹,

Saheeb²,

Kadhem³

2017

Chem Sci J

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Gallstones disease is well known over the world. It causes death for about 5% of Al-Maghreb people. Whereas Missan city showed a lot of cases for new born babies which they born with gallstones in their gallbladders. These unusual cases lead this research to study the reason of this disease and its right treatment. Results of this research based on atomic absorption technique that indicated that gallstones of different samples contain: 0.386, 0.75, 1.17 and 1.283% of aluminum ions. While references indicated that there is no aluminum in gallstones in the world. These stones are mainly developed from cholesterol, bile salts, phospholipids (lecithin), bilirubin, calcium, and estrogen (for women). Gallstones disease is another disease that mainly caused by civilization and its treatment according to this research is by eating different food with so little cholesterol content comparing with very high other lipids such as triacylglycerol or different fatty acids in relatively limiting time etc. Although gallstones disease was well studied by many scientists during the last hundred years, it reason is not clear because it needs chemists touch.

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“…Age is an independent risk factor for GD. The prevalence of cholelithiasis is estimated to be between 0.13% and 2% in children less than 19 years and is lower than that in adolescents (16)(17)(18). Therefore, we excluded patients under 15 years.…”

Section: Shi Et Al Gallstones Subjected To Liver Transplantationmentioning

confidence: 99%

Gallstones in liver transplant recipients: A single-center study in China

Shi¹,

Shen²,

Teng³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Liver transplant recipients include patients who present with almost all kinds of end-stage liver disease. Studying the relationship between gallstones and end-stage liver disease among liver transplant recipients is becoming important. Materials and Methods: Multiple logistic regression analysis was applied to assess 1640 liver transplant recipients. Multiple factors were involved in the analysis, including age, sex, total bilirubin and total cholesterol levels, Child score, hepatitis B virus (HBV) infection, hepatitis C virus (HCV) infection, alcoholic cirrhosis, and hepatocellular carcinoma (HCC). Results: Age and Child score are independent risk factors for the development of gallstone disease (GD). The average age of the recipients in the GD group was 49.22±9.96 years, which was significantly higher than that in the GD-free group (48.23±9.79 years). The Child score of the recipients in the GD group was 9.21±2.47, which was significantly lower than that of the recipients in the GD-free group, which was 8.79±2.48 (t=3.23, p<0.001). We also found that hepatitis B is an influential factor in GD. Conclusion: The prevalence of gallstones among liver transplant recipients is related to the Child score and patient age. The prevalence of GD is lower in patients with HCC and in those who are HBV positive and is relatively higher in HCV-positive patients and in those with alcoholic cirrhosis, although no significant differences were found.

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Hereditary liver disease: Gallstones

Cited by 47 publications

References 77 publications

Evidence-based clinical practice guidelines for cholelithiasis 2016

Evidence-based clinical practice guidelines for cholelithiasis 2016

Gallstones Disease 'Cholelithiasis', Reasons and Solutions

Gallstones in liver transplant recipients: A single-center study in China

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