Hereditary gastrointestinal cancer

Hata, Keisuke; Yamamoto, Yasutake; Kiyomatsu, Tomomichi; Tanaka, Toshiaki; Kazama, Shinsuke; Nozawa, Hiroaki; Kawai, Kazushige; Tanaka, Junichiro; Nishikawa, Takeshi; Otani, Kensuke; Yasuda, Koji; Kishikawa, Junko; Nagai, Yoshinori; Anzai, Hiroyuki; Shinagawa, Takahiro; Arakawa, K; Yamaguchi, Hironori; Ishihara, Soichiro; Sunami, Eiji; Kitayama, Joji; Watanabe, Toshiaki

doi:10.1007/s00595-015-1283-3

Cited by 21 publications

(8 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present case, the patient did not meet the Amsterdam II Criteria or the Revised Bethesda Guidelines. Other major hereditary gastrointestinal cancer syndromes are familial adenomatous polyposis (FAP), Li-Fraumeni syndrome, Hereditary diffuse gastric cancer (29). FAP is an autosomal dominant disease that is classically characterized by the development of hundreds to thousands of adenomas in the rectum and colon during the second decade of life (30).…”

Section: Discussionmentioning

confidence: 99%

Multiple primary malignancies of six organs in a Japanese male patient: A case report

et al. 2019

View full text Add to dashboard Cite

As a result of recent advances in diagnostic techniques and treatment modalities, the number of patients diagnosed with multiple primary malignancies has been increasing. We report the case of a 79-year-old male with multiple primary malignancies of three histological types in six different organs: Stomach, prostate, colon, urinary bladder, facial skin and pancreas, in chronological order. The first malignancy was upper gastric cancer diagnosed in 1998. The second and third malignancies were prostate cancer and ascending colon cancer, which were diagnosed in 2010. The fourth malignancy was bladder cancer diagnosed in 2011. The fifth and sixth malignancies were squamous cell skin cancer of the right cheek and intraductal papillary mucinous carcinoma (IPMC), respectively, diagnosed in 2014. The gastric cancer, colon cancer, bladder cancer, skin cancer and IPMC were surgically resected. The prostate cancer was treated by anti-androgen therapy. The patient died of local recurrence of IPMC in August 2016. Although multiple primary malignancies are not uncommon, diagnosis of six primary malignancies in a single patient, as reported in the present study, is extremely rare. It is important to understand the characteristics of multiple primary malignancies in order to administer suitable treatment and determine relevant follow-up plans for patients with cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Multiple primary malignancies of six organs in a Japanese male patient: A case report

et al. 2019

View full text Add to dashboard Cite

show abstract

“…This patient had seven carcinomas in the gastrointestinal tract—with lesions in the esophagus, stomach, and colorectum—and a tumor in the prostate gland and external ear canal. The major relevant hereditary gastrointestinal cancer syndromes are familial adenomatous polyposis (FAP), Lynch syndrome, hereditary diffuse gastric cancer, and Li-Fraumeni syndrome [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough cases of multiple primary malignant neoplasms are increasing, reports of more than three or four primary metachronous malignant neoplasms are extremely rare. Moreover, very few publications have provided a genetic mutational analysis or have evaluated risk factors associated with such neoplasms. We present an extremely rare case of nine primary malignant lesions in a man who was successfully treated. We also report on microsatellite stability status, analyze risk factors, and discuss the relevant literature.Case presentationBetween 67 and 73 years of age, a male patient developed nine primary metachronous malignant lesions: Three were located in the esophagus, two in the stomach, two in the colorectum, one in the prostate gland, and one in the external ear canal. The patient’s clinical history included hypertension, atrial fibrillation, an acoustic schwannoma, and heavy smoking. The lesions were diagnosed during regular screening over a six-year period. He was successfully treated with surgery (both open surgical and endoscopic resection of lesions) and adjuvant chemotherapy. Immunohistochemistry and mutational analysis showed that the lesions were microsatellite stable, and the KRAS, BRAF, p53, and nuclear β-catenin status was not uniform among the lesions.ConclusionsGiven that the presence of more than three or four neoplasms is extremely rare, the present case of nine primary malignancies with no associated microsatellite instability and no apparent predisposing hereditary conditions, is extraordinary. Our case study shows that it is possible for up to nine sporadic neoplasms to occur, and efficient disease management requires diligent screening and early detection.Electronic supplementary materialThe online version of this article (10.1186/s12885-017-3973-2) contains supplementary material, which is available to authorized users.

show abstract

“…In general, episodes of pouchitis are more associated with colectomy due to UC, than to neoplastic or familial polyposic syndromes. In these latter cases, the incidence of pouchitis ranges from 0% to 11%, which is lower than in colectomies secondary to UC, and could be explained by the immune-mediated etiology of UC (7)(8)(9) .…”

Section: Introductionmentioning

confidence: 94%

Diagnostic and Management Approach to Pouchitis in Inflammatory Bowel Disease

Sedaño

Núñez

Quera

2020

Arq. Gastroenterol.

View full text Add to dashboard Cite

In patients with ulcerative colitis refractory to medical therapy, total proctocolectomy and posterior ileal-anal pouch anastomosis is the standard surgical therapy. One of the possible complications is pouchitis. Depending on the duration of the symptoms, it can be classified as acute, recurrent, or chronic. The latter, according to the response to therapy, can be defined as antibiotic-dependent or refractory. The treatment of pouchitis is based on the use of antibiotics and probiotics. Thiopurine and biological therapy have been suggested in patients with refractory pouchitis. Special care should be taken in the endoscopic surveillance of these patients, especially if they present risk factors such as dysplasia or previous colorectal cancer, primary sclerosing cholangitis or ulcerative colitis for more than 10 years.

show abstract

Hereditary gastrointestinal cancer

Cited by 21 publications

References 61 publications

Multiple primary malignancies of six organs in a Japanese male patient: A case report

Multiple primary malignancies of six organs in a Japanese male patient: A case report

Nine primary malignant neoplasms-involving the esophagus, stomach, colon, rectum, prostate, and external ear canal-without microsatellite instability: a case report

Diagnostic and Management Approach to Pouchitis in Inflammatory Bowel Disease

Contact Info

Product

Resources

About