Hereditary Diabetes in the KK Mouse: An Overview

Reddi, Alluru S.; Camerini-Dávalos, Rafael A.

doi:10.1007/978-1-4684-5616-5_2

Cited by 27 publications

(22 citation statements)

References 5 publications

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“…2) is consistent with previous studies reporting that KK mice develop albuminuria after ϳ10 weeks of age (17). The factors contributing to albuminuria in KK/HlJ mice have not been fully elucidated, but spontaneous glucose intolerance and hyperinsulinemia have been previously reported (17,41,44). Regardless, STZ-induced diabetes produced a further increase in albuminuria in KK/HlJ mice, demonstrating that this strain is also susceptible to diabetic albuminuria.…”

Section: Diabetes Vol 54 September 2005supporting

confidence: 91%

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Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

et al. 2005

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Differential susceptibility to diabetic nephropathy has been observed in humans, but it has not been well defined in inbred strains of mice. The present studies characterized the severity of diabetic nephropathy in six inbred mouse strains including C57BL/6J, DBA/2J, FVB/NJ, MRL/MpJ, A/J, and KK/HlJ mice. Diabetes mellitus was induced using low-dose streptozotocin injection. Progression of renal injury was evaluated by serial measurements of urinary albumin excretion, glomerular filtration rate (GFR), and terminal assessment of renal morphology over 25 weeks. Despite comparable levels of hyperglycemia, urinary albumin excretion and renal histopathological changes were dramatically different among strains. DBA/2J and KK/HlJ mice developed significantly more albuminuria than C57BL/6J, MRL/MpJ, and A/J mice. Severe glomerular mesangial expansion, nodular glomerulosclerosis, and arteriolar hyalinosis were observed in diabetic DBA/2J and KK/HlJ mice. Glomerular hyperfiltration was observed in all diabetic strains studied except A/J. The significant decline in GFR was not evident over the 25-week period of study, but diabetic DBA/2J mice exhibited a tendency for GFR to decline. Taken together, these results indicate that differential susceptibility to diabetic nephropathy exists in inbred mice. DBA/2J and KK/HlJ mice are more prone to diabetic nephropathy, whereas the most widely used C57BL/6J mice are relatively resistant to development of diabetic nephropathy. Diabetes 54:2628 -2637, 2005

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Section: Diabetes Vol 54 September 2005supporting

confidence: 91%

“…The KK strain has previously been proposed to represent a model of diabetic nephropathy (17,(41)(42)(43). The present finding of moderate albuminuria in nondiabetic KK/HlJ mice (Fig.…”

Section: Diabetes Vol 54 September 2005supporting

confidence: 61%

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

et al. 2005

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“…Selected inbreeding has yielded the KK mouse, which shows moderate obesity, hyperinsulinemia, and hyperglycemia (Reddi and Camerini-Davalos 1988). The NSY mouse, which manifests hyperglycemia (200 mg/dL) at 120 min during an intraperitoneal glucose tolerance test, has been defined as "diabetic" by the investigators (Ueda et al 1995(Ueda et al , 2000.…”

Section: Inbred Mouse Modelsmentioning

confidence: 99%

Molecular Approaches to Study Control of Glucose Homeostasis

Neubauer

Kulkarni²

2006

ILAR Journal

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Type 2 diabetes is a polygenic disease that can lead to severe complications in multiple tissues. Rodent models have been used widely for investigating the pathophysiology underlying type 2 diabetes and for examining the potential link with obesity, largely due to the limitations of invasive testing and of studying detailed molecular mechanisms in human tissues. Among rodents, the mouse model is especially popular because mice are easy to manipulate genetically, have a short generation time, and are relatively inexpensive. The most commonly used inbred mouse strains are reviewed in addition to several genetically engineered mouse models that have been generated to study type 2 diabetes in the context of obesity, with a focus on insulin, leptin, and peroxisome proliferator-activated receptor (PPAR) signaling pathways.

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“…The KK mice become obese once with the onset of adulthood and develop insulin resistance, subsequent hyperinsulinemia and β-cell hyperplasia. Particularly, KK mice present a chemical diabetic stage preceded by prediabetes stage accompanied by renal, neurological and retinal complications [93]. The severity of diabetes is strongly correlated with environmental factors such as diet, food intake and social isolation of the animals, the chemical diabetic state being replaced with overt diabetes [94,95].…”

Section: Animal Models Of Non-insulin Dependent Diabetes Mellitus (Nimentioning

confidence: 99%

Development of Improved Animal Models for the Study of Diabetes

Ciobotaru¹

2013

Diabetes Mellitus - Insights and Perspectives

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Hereditary Diabetes in the KK Mouse: An Overview

Cited by 27 publications

References 5 publications

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

Characterization of Susceptibility of Inbred Mouse Strains to Diabetic Nephropathy

Molecular Approaches to Study Control of Glucose Homeostasis

Development of Improved Animal Models for the Study of Diabetes

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