Hereditary defects and conservation genetic management of captive populations

Laikre, Linda

doi:10.1002/(sici)1098-2361(1999)18:2<81::aid-zoo1>3.0.co;2-2

Cited by 36 publications

(4 citation statements)

References 49 publications

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“…Among the mammal species, the following decreasing order of proportion was diversity from endogamy (Laikre 1999). Such an approach consists of the use of genetic analyses for species preservation focused on faunistic restoration capable of responding to environmental transformations and minimizing the risk of extinction (Frankham et al 2002).…”

Section: Resultsmentioning

confidence: 99%

Assessment of Genome Damage in Bird and Mammal Species as a Tool for Improvements in ex-situ Conservation at Zoos

Adam¹,

Torres²,

Kiska³

et al. 2013

NatCon

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Ex-situ conservation at zoos requires strategies regarding improvements to enclosures, as ex-situ conserved specimens constitute an effective reservoir for genetic and biological restoration. The present study focuses on the management of enclosures at zoos and offering an accurate, fast and inexpensive procedure for ex-situ conservation through the assessment of the degree of genome damage (micronuclei) in different bird and mammal species. Analyses of variance revealed statistically significant differences in both bird and mammal species, in comparison to their reference groups. All bird species and Tapirus terrestris had high proportional micronucleus indexes, indicating high susceptibility to genome damage through contact with polluted water from the river used to supply the enclosures. Recognizing the relationship between water quality (evaluated at entry and exit of water in the zoo) and habitat deterioration as well as individual responses to these factors in terms of genotoxicity make efforts directed at ex-situ conservation an urgent priority.

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Section: Resultsmentioning

confidence: 99%

Assessment of Genome Damage in Bird and Mammal Species as a Tool for Improvements in ex-situ Conservation at Zoos

Adam¹,

Torres²,

Kiska³

et al. 2013

NatCon

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“…Albinism in a number of natural and captive animal systems arises through de novo genetic mutations (Brown and Norris, 1956;Frankham et al, 1986;Laikre, 1999;Clark, 2002;McPhee, 2004;Pelletier et al, 2009). Indeed de novo mutations could, in principle, explain the presence of albinism in Micos cavefish; however, we believe this is unlikely.…”

Section: Standing Genetic Variation Versus De Novo Mutationsmentioning

confidence: 85%

Albinism in phylogenetically and geographically distinct populations of Astyanax cavefish arises through the same loss-of-function Oca2 allele

Gross

Wilkens

2013

Heredity

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The Mexican tetra, Astyanax mexicanus, comprises 29 populations of cave-adapted fish distributed across a vast karst region in northeastern Mexico. These populations have a complex evolutionary history, having descended from 'old' and 'young' ancestral surface-dwelling stocks that invaded the region B6.7 and B2.8 MYa, respectively. This study investigates a set of captive, pigmented Astyanax cavefish collected from the Micos cave locality in 1970, in which albinism appeared over the past two decades. We combined novel coloration analyses, coding sequence comparisons and mRNA expression level studies to investigate the origin of albinism in captive-bred Micos cavefish. We discovered that albino Micos cavefish harbor two copies of a loss-of-function ocular and cutaneous albinism type II (Oca2) allele previously identified in the geographically distant Pachó n cave population. This result suggests that phylogenetically young Micos cavefish and phylogenetically old Pachón cave fish inherited this Oca2 allele from the ancestral surface-dwelling taxon. This likely resulted from the presence of the loss-offunction Oca2 haplotype in the 'young' ancestral surface-dwelling stock that colonized the Micos cave and also introgressed into the ancient Pachón cave population. The appearance of albinism in captive Micos cavefish, caused by the same loss-offunction allele present in Pachó n cavefish, implies that geographically and phylogenetically distinct cave populations can evolve the same troglomorphic phenotype from standing genetic variation present in the ancestral taxon.

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“…There are documented examples of inherited disorders in captive populations of endangered species (Laikre, 1999;Ralls et al, 2000), which would have important negative consequences for animals reintroduced to the wild. Although these recessive alleles are in low frequency, many individuals in the population may be heterozygous for them.…”

Section: Detrimental Variationmentioning

confidence: 99%

Recent developments in conservation genetics

Hedrick

2004

Forest Ecology and Management

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Hereditary defects and conservation genetic management of captive populations

Cited by 36 publications

References 49 publications

Assessment of Genome Damage in Bird and Mammal Species as a Tool for Improvements in ex-situ Conservation at Zoos

Assessment of Genome Damage in Bird and Mammal Species as a Tool for Improvements in ex-situ Conservation at Zoos

Albinism in phylogenetically and geographically distinct populations of Astyanax cavefish arises through the same loss-of-function Oca2 allele

Recent developments in conservation genetics

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