Hereditary Defect of the Pilosebaceous Unit in a New Double Mutant Mouse**From the Department of Gynecology and Obstetrics and the Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305.

Gates, Allen H.; Arundell, Faye D.; Karasek, Marvin A.

doi:10.1038/jid.1969.18

Cited by 19 publications

(2 citation statements)

References 2 publications

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“…Normal development and function of the sebaceous glands are very important for correct hair development and cycling. Abnormal functioning of sebaceous glands and druginduced degeneration of sebaceous glands in association with hair loss have been reported (1)(2)(3)(4)(5)(6). Although sebaceous glands in nevus sebaceus are usually numerous and hyperplastic, they are immature and demonstrate malpositioning.…”

Section: Introductionmentioning

confidence: 99%

The effect of sebocytes cultured from nevus sebaceus on hair growth

Lee

Wuk

Lim

et al. 2012

Experimental Dermatology

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Sebaceous glands are known to affect hair growth. Nevus sebaceus, a sebaceous gland hamartomas, presents as hairless patches. In this study, cultures of nevus sebaceus sebocytes (NSS) and normal scalp hair follicle sebocytes (NS) were used in performance of microarray, RT-PCR, western blot assay and immunofluorescence staining. NSS-and NS-conditioned media were also added to the culture of outer root sheath cells (ORSCs), dermal papilla cells (DPCs) or normal scalp hair follicle sebocytes. Results of this study showed a decrease in the survival rate of ORSCs and DPCs and hair growth in the NSS-conditioned medium-treated group, compared with the control and NSconditioned medium-treated groups. An increase in expression of fibroblast growth factor (FGF)-5, Dickkopf-1 and inflammatory cytokines and a decrease in expression of Wnt10b and Lef1 were observed. In conclusion, NSS showed an increase in expression of hair growth-suppressing bioactive factors, including FGF-5, and a decrease in expression of hair growth-stimulating factors.

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Section: Introductionmentioning

confidence: 99%

The effect of sebocytes cultured from nevus sebaceus on hair growth

Lee

Wuk

Lim

et al. 2012

Experimental Dermatology

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“…, nude, naked, hairless, and rhino are now available for experimental use [6,12,14,15]. A single gene mutation produces the rhino strain, which is allelic to the hairless gene [8].…”

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confidence: 99%

Growth of the Mammary Gland in Rhino Mouse

Tsubura

Morii

Ikehara

1993

Experimental Animals

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Hair loss and cyst formation in hairless and rhino mutant mice

Mann

1971

Anat. Rec.

107

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Structural abnormalities begin in the integument of hairless (hrhr), hairless-rhino ( hrhrrh), and rhino (hrVhhrrh) male and female mutant mice prior to the end of the first hair growth cycle. The pilary canals begin to widen and accumulate keratin and sebaceous material. During the first catagen phase the lower internal root sheath coalesces around the terminal part of the hair shaft and abnormal club hairs form. The lower part of the external root sheath fails to follow the ascending club hair and becomes stranded in the dermis. The abnormal club hairs move above their normal anchoring position and fall out of the follicle at the end of the first growth cycle. The formation of abnormal club hairs and the loss of hair probably are related to the mispositioning of the internal root sheath. Subsequent to the loss of hair there are changes in the sebaceous glands and adipose tissue, disorganization of the peripheral neurovascular system, and the formation of cysts that are associated with either the pilary canals or with epithelial units of disorganized hair follicles stranded in the dermis. Cysts arise from proliferation of epithelial tissue; sebaceous cells are not necessary for cyst formation.Comparisons among similar and dissimilar anomalies indicate that the degree of gene action on the integument is in the following order of increased severity: hrhr, hrhrrh, and hrThhrrh.

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Hereditary Defect of the Pilosebaceous Unit in a New Double Mutant Mouse**From the Department of Gynecology and Obstetrics and the Department of Dermatology, Stanford University School of Medicine, Stanford, California 94305.

Cited by 19 publications

References 2 publications

The effect of sebocytes cultured from nevus sebaceus on hair growth

The effect of sebocytes cultured from nevus sebaceus on hair growth

Growth of the Mammary Gland in Rhino Mouse

Hair loss and cyst formation in hairless and rhino mutant mice

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