Hereditary Colon Cancer: Polyposis and Nonpolyposis Variants

Lynch, Henry T.; Rozen, Paul; Schuelke, Guy S.

doi:10.3322/canjclin.35.2.95

Cited by 27 publications

(12 citation statements)

References 57 publications

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“…Such a policy should be cost-effective because the number of colorectal cancer cases is small compared to that in other countries. For such a study, screening tools should include: fecal occult blood test, 60-cm flexible sigmoidoscopy, colonoscopy, and barium enema [10].…”

Section: Discussionmentioning

confidence: 99%

Colorectal Carcinoma: Review of 110 Cases

1990

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Section: Discussionmentioning

confidence: 99%

Colorectal Carcinoma: Review of 110 Cases

1990

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“…Hereditary nonpolyposis colon cancer was identified by Lynch and colleagues (100,101) in the early 1980s. It is distinguished from familial adenomatous polyposis syndrome, which is characterized by numerous colonic polyps that progress to colon cancer.…”

Section: Hereditary Nonpolyposis Colon Cancermentioning

confidence: 99%

Hereditary Renal Cancers

Choyke¹,

Glenn²,

Walther³

et al. 2003

Radiology

204

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Hereditary renal cancer syndromes can lead to multiple bilateral kidney tumors that occur at a younger age than do nonhereditary renal cancers. Imaging plays an important role in the diagnosis and management of these syndromes. During the past decade, several new hereditary renal syndromes have been discovered but are not yet widely known. Whereas previously, the list of hereditary renal cancers in adults included von Hippel-Lindau disease and a rare form of chromosomal translocation, the list now includes the following syndromes: tuberous sclerosis, hereditary papillary renal cancer, Birt-Hogg-Dubé syndrome, hereditary leiomyoma renal cell carcinoma, familial renal oncocytoma, hereditary nonpolyposis colon cancer, and medullary carcinoma of the kidney. In addition, a number of newly described but poorly understood syndromes are under investigation. Even at this early stage, it is clear that elucidation of the underlying genetic mutations that cause hereditary renal cancer syndromes will have profound implications for understanding the origins of nonhereditary renal tumors. These studies will likely culminate in a better understanding of the causes of renal cancer, its prevention, and, ultimately, its cure.

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“…Probably the best and cheapest method of identifying this cohort is through a detailed family history. Clearly, first‐ degree relatives are at increased risk for developing bowel cancer, even if they do not appear to be in a FAP or HNPCC family 159–162 . As a result, these high‐risk individuals should be candidates for regular screening and, perhaps, should be considered for genetic testing.…”

Section: Future Potential For Molecular Diagnostic Testsmentioning

confidence: 99%