Hereditary clear cell meningiomas in a single family: three-cases report

Inoue, Tan; Shitara, Satoshi; Ozeki, Michio; Nozawa, Akifumi; Fukao, Toshiyuki; Fukushima, Takanori

doi:10.1007/s00701-018-3727-1

Cited by 10 publications

(14 citation statements)

References 15 publications

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“…Based on these intraoperative findings, the site of origin could not be determined, but the tumor was considered to be located mainly between the dura mater and arachnoid. Intraoperative images of pediatric spinal CCMs have been reported only in a limited number of cases, 16,20,29,30) and this is the first report to provide a detailed review of intraoperative findings. In order to identify the origin, dural incision and arachnoid incision should be performed separately; otherwise the location of the tumor becomes ambiguous.…”

Section: Fig 1 Lumbar Spine Ct Showed High Absorption At the L3 Vertebral Level (A) And Lumbar Mri T1-weighted Images Showed Faint High Smentioning

confidence: 94%

“…3) Meningiomas generally adhere to the dura mater, 33,34) but cases of CCM not attached to the dura have been reported. 3,5,6,[10][11][12][13][14][16][17][18]25,29,30) In such cases, the tumor is often attached to the nerve root. Lee et al reported that 15 (83.3%) of 18 cases of spinal meningiomas did not have a dural attachment, 34) and lack of dural attachment is characteristic of this disease.…”

Section: Fig 1 Lumbar Spine Ct Showed High Absorption At the L3 Vertebral Level (A) And Lumbar Mri T1-weighted Images Showed Faint High Smentioning

confidence: 99%

“…8,2021 was no dural attachment. 3,5,6,[10][11][12][13][14][16][17][18]25,29,30) There is therefore currently no settled opinion on the origin of these tumors, 13,33,35) and no report has ever reviewed the intraoperative findings in detail. In this study, we intraoperatively examined the detailed anatomical location of this tumor.…”

Section: Introductionmentioning

confidence: 99%

“…3 , 5 – 32) Meningiomas, as a rule, adhere to the dura mater, 33 , 34) but one of the characteristics of CCMs is that 15 cases have been reported at the moment in which there was no dural attachment. 3 , 5 , 6 , 10 – 14 , 16 – 18 , 25 , 29 , 30) There is therefore currently no settled opinion on the origin of these tumors, 13 , 33 , 35) and no report has ever reviewed the intraoperative findings in detail. In this study, we intraoperatively examined the detailed anatomical location of this tumor.…”

Section: Introductionmentioning

confidence: 99%

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Intraoperative Anatomical Findings in Pediatric Clear Cell Meningioma of the Lumbar Spine: Case Report and Literature Review

Ikeda

Isoo

Sakakibara

et al. 2021

NMC Case Report Journal

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Clear cell meningioma (CCM) is a WHO classification Grade II meningioma. It is a very rare disease, of which only 41 cases of spinal cord CCM in children have been reported to date. CCMs sometimes do not have the "dural attachment" that is usually found in meningiomas, and our understanding of the origin of CCMs is therefore controversial. We hereby present a case of pediatric CCM of the lumbar spine, in which we examined intraoperatively, the detailed anatomical location of the tumor. The case is a 10-year-old boy, who presented to our hospital with a 2-month history of lower back and bilateral lower extremity pain upon waking, which gradually worsened. Lumbar spine CT and MRI revealed an intradural extramedullary tumor at the L3 vertebral level, and surgery was performed to remove it. The tumor was in close contact with the dura mater, and also in contact with the cauda equina via the arachnoid. The tumor was likely located primarily between the dura mater and arachnoid. The pathological diagnosis was CCM, with an MIB-1 index of less than 1%. His back pain and bilateral lower extremity pain improved after surgery, and he was discharged from our hospital. Postoperative radiation therapy was not performed. Based on this case, we suggest that intraoperative examination of the anatomical location of these tumors and accumulation of relevant experience are important to elucidate the embryological mechanisms of this rare disease.

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Section: Fig 1 Lumbar Spine Ct Showed High Absorption At the L3 Vertebral Level (A) And Lumbar Mri T1-weighted Images Showed Faint High Smentioning

confidence: 94%

Section: Fig 1 Lumbar Spine Ct Showed High Absorption At the L3 Vertebral Level (A) And Lumbar Mri T1-weighted Images Showed Faint High Smentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intraoperative Anatomical Findings in Pediatric Clear Cell Meningioma of the Lumbar Spine: Case Report and Literature Review

Ikeda

Isoo

Sakakibara

et al. 2021

NMC Case Report Journal

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show abstract

“…A Japanese study has described familial CCM in a single family with cases of both spinal and cranial (cerebello-pontine angle) SMARCE1 -deficient tumors and a germline SMARCE1 mutation ( 6 ).…”

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confidence: 99%