Hereditary Cataracta Caerulea

Wolfe, Otis; Wolfe, Russell M.

doi:10.1097/00006324-194112000-00019

Cited by 3 publications

(2 citation statements)

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“…Individuals are uniquely identified by integers, and those affected by blue dot cataract are coloured black. The disease has long been recognized as genetically determined (Wolfe and Wolfe, 1943) and is believed to be controlled by a single locus at which the allele for the trait is dominant to the normal allele, as is the case for most inheritable cataracts (Marner, 1949). That the trait appears to be passed down without missing a generation, as can be seen from Fig.…”

Section: Mode Oj Inheritancementioning

confidence: 99%

Gene Hunting with Gradients of Likelihoods

Thomas

1991

Journal of the Royal Statistical Society Series B: Statistical Methodology

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When analysing the mode of inheritance of a genetic trait, or mapping its location on the human genome, computationally intensive likelihood calculations are required. The standard method, called peeling, is reviewed here and an extension to the calculation of gradients is implemented. The gradients are used for numerical searches for maximum likelihood estimates, and also for producing contour plots of log-likelihood surfaces. This is illustrated with an analysis of the mode of inheritance, of the eye disease blue dot cataract, and of its proximity to a genetic marker on chromosome 16.

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Section: Mode Oj Inheritancementioning

confidence: 99%

Gene Hunting with Gradients of Likelihoods

Thomas

1991

Journal of the Royal Statistical Society Series B: Statistical Methodology

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“…It may be transmitted as an autosomal dominant trait [Halbertsma, 1928;Vogt. 1930;Wolfe and Wolfe. 1943], On the other hand, true juvenile cataracts are not rare and there are many pedigrees demonstrating the autosomal dominant in heritance of some of these cataracts [Rowan and Wilson, 1921;Veil and Favory, 1930; What about senile cataracts'!…”

Section: Juvenile Presenile and Senile Cataractsmentioning

confidence: 99%