Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines

Abstract

Hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers; however, familial forms are believed to account for up to 30% of some cancers. In Hispanics, the most commonly diagnosed hereditary cancers include colorectal cancer syndromes such as, Lynch Syndrome, Familial Adenomatous Polyposis, and hereditary breast and ovarian cancer syndromes. Although the incidence of hereditary cancers is low, patients diagnosed with hereditary cancer syndromes are at high-risk for developing secondary cancers. Furthermore, the productivity loss that occurs after cancer diagnosis in these high-risk patients has a negative socio-economic impact. This review summarizes the genetic basis, phenotype characteristics, and the National Comprehensive Cancer Network’s screening, testing, and surveillance guidelines for the leading hereditary cancer syndromes. The aim of this review is to promote a better understanding of cancer genetics and genetic testing in Hispanic patients.

Frequency of Mismatch Repair Protein Deficiency in a Puerto Rican Population with Colonic Adenoma and Adenocarcinoma

“…(17). However, Caribbean Puerto Ricans MMR studies suggest a higher prevalence of MSH2 mutations among Puerto Rican patients compared to MLH1 mutations among Portuguese and Spanish patients despite of shared Spanish ancestry (18). The aim of the study is to assess the frequency of alterations in MMR protein expression in both primary colorectal cancer and precursor lesions of Puerto Rican patients.…”

Prognostic Biomarkers of Gastrointestinal Neoplasia

“…Более 90 % случаев КРР, ассоциированных с синдромом Линча, составляют КРР фенотипа МСН + . Начало заболевания при синдроме Линча приходится на молодой возраст: к 20 годам большинство пациентов имеют по меньшей мере 1 аденоматозный полип, а к 50 годам -аденокарциному [44]. Наследственная форма полипозного КРР вызвана герминативной мутацией в гене APC.…”

Education on cancer risk assessment and genetic counseling to address cancer health disparities among racial/ethnic groups and rural populations: Implementing culturally tailored outreach through community health educators

“…Cancer is the second‐leading cause of death among men and women in the United States, (National Cancer Institute, 2014‐2016) and hereditary cancer predisposition syndromes comprise approximately 10% of diagnosed cancers. (Cruz‐Correa et al, 2017) Of those diagnosed, at least 15% of individuals with cancer are candidates for cancer genetic counseling. (Stoll, Kubendran, & Cohen, 2018) Broader access to GCRA may inform individuals from R/E groups who have cancer about treatment options, risk projections for secondary cancers, and clinical trial participation.…”