Hereditary Breast and Ovarian Cancer Screening Syndrome Profile in Women Diagnosed with Breast Cancer from Paraná State Southwest

Abstract

Objective This study evaluated the risk of the hereditary breast and ovarian cancer (HBOC) syndrome in patients with breast cancer by using the Family History Screening 7 (FHS-7) tool, a validated low-cost questionnaire with high sensitivity able to screen the HBOC risk in the population. Methods Women diagnosed with breast cancer (n = 101) assisted by the Unified Health System at the 8th Regional Health Municipal Office of the state of Paraná answered the FHS-7, and the results were analyzed using IBM SPSS Statistics for Windows, Version 25.0. software (IBM Corp., Armonk, NY, USA). Results The risk of HBOC was 19.80% (n = 20). Patients at risk exhibited aggressive tumor characteristics, such as high-grade tumors (30%), presence of angiolymphatic emboli (35%), and premenopausal at diagnosis (50%). Significant associations between the prevalence of high-grade tumors were observed in women younger than 50 years at diagnosis with HBOC (p = 0.003). Conclusion Our findings suggest a possible family inheritance associated with worse clinical features in women with breast cancer in this population, indicating that HBOC investigation can be initially performed with low-cost instruments such as FHS-7.

Exposure to Pesticides and Breast Cancer in an Agricultural Region in Brazil

“…Further, little attention has been given to other chronic, life-threatening pathologies such as BC. The gap is particularly relevant because BC is the leading cause of women’s death worldwide, a cancer for which most cases result from environmental factors and life habits, with a minority of cases attributable to heritable high-risk genes . Evidence addressing BC risk and pesticide exposure for potentially exposed women is not well documented.…”

“…The gap is particularly relevant because BC is the leading cause of women’s death worldwide, a cancer for which most cases result from environmental factors and life habits, with a minority of cases attributable to heritable high-risk genes. 41 Evidence addressing BC risk and pesticide exposure for potentially exposed women is not well documented. Indeed, data concerning specific pesticide exposures or pesticide measurement in biological samples from female rural workers are typically unavailable.…”