“…A comparison between the EQ-5D and an angioedema-specific quality of life instrument revealed multiple differences that could have a significant effect on the analysis. 12 Angioedema-specific, as well as HAE-specific, quality of life instruments have been developed and validated but were not used for this analysis. 13,14 A greater concern is the relatively modest improvement in QALY assigned to patients treated with prophylactic medications in this model.…”