Hereditary Amyloidosis, the Flexor Retinaculum, and the Carpal Tunnel Syndrome

Lambird, Perry A.; Hartmann, William H.

doi:10.1093/ajcp/52.6.714

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Introduction3

Is Cts a Multifactorial Disease That Involves An Important G1

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Cited by 39 publications

(8 citation statements)

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“…With some frequency, a peak in the region corresponding to an a,-globulin can be demonstrated in sera from these patients [5]. Histo logically, the amyloid deposits are predominantly found in the retinacu lum flexorum manus [16], in the fascia of the calf and in the vascular walls.…”

Section: Introductionmentioning

confidence: 90%

Amyloidotic Polyneuritis of Type III (Iowa-Van Allen)

et al. 1974

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Section: Introductionmentioning

confidence: 90%

Amyloidotic Polyneuritis of Type III (Iowa-Van Allen)

et al. 1974

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“…4 Familial occurrence of CTS also has been documented. [52][53][54][55][56][57] When CTS is inherited, it is often the manifestation of a systemic disease. 58 Gossett and Chance 57 concluded that in addition to linkage with FAP and HNPP, patients may present with a familial CTS.…”

Section: Is Cts a Multifactorial Disease That Involves An Important Gmentioning

confidence: 99%

Assessment of the Scientific Basis for Genetic Testing of Railroad Workers with Carpal Tunnel Syndrome

Schulte

Lomax²

2003

Journal of Occupational and Environmental Medicine

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In 2000, approximately 20 railroad track workers who filed injury reports or compensation claims for carpal tunnel syndrome were tested by their employer for two genetic traits to determine the work relatedness of the condition. The testing involved deletions, variants, or mutations in the genetic coding for peripheral myelin protein (PMP22) and transthyretin (TTR). This article is an assessment of whether there is a scientific basis for such testing. A review of the scientific literature indicated that neither the scientific basis nor the population validity of the PMP22 or TTR tests for carpal tunnel syndrome were adequately established before use on railroad track workers in 2000. Although ethical and legal issues may predominate in this case, the absence of a compelling scientific basis undermines the decision to conduct the tests.

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“…While this syndrome usually occurs spo radically, familial instances are well known [1][2][3][4][5][6]. In some of the familial cases, median nerve compression results from a recognized cause such as amyloidosis, mu copolysaccharidosis, mucolipidosis, or polyneuropathy [2][3][4], Occasionally, the familial cases have no recognizable cause. We now report the genetic linkage studies in one such family.…”

Section: Introductionmentioning

confidence: 99%