Herding the U.S. cattle industry toward a paradigm shift in parasite control

McArthur, M; Reinemeyer, Craig R.

doi:10.1016/j.vetpar.2013.12.021

Cited by 43 publications

(23 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the current study indicate that anthelmintic resistance is an increasing reality in three major cattle rearing countries in Europe, and that this concerns not only the dose-limiting species but also O. ostertagi . This should incite the different stakeholders, farmers as well as vets and industry, to work towards what has been referred to as a paradigm shift in parasite control ( McArthur and Reinemeyer, 2014 ). The key message is that management advice should be based on a sound understanding of the parasite epidemiology and farm management, past and present, and that the requirement for and appropriate timing of treatment should be established based on faecal examinations.…”

Section: Discussionmentioning

confidence: 99%

Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe

Geurden

Chartier

Fanke

et al. 2015

International Journal for Parasitology: Drugs and Drug Resistan

133

View full text Add to dashboard Cite

Anthelmintic resistance has been increasingly reported in cattle worldwide over the last decade, although reports from Europe are more limited. The objective of the present study was to evaluate the efficacy of injectable formulations of ivermectin and moxidectin at 0.2 mg per kg bodyweight against naturally acquired gastro-intestinal nematodes in cattle. A total of 753 animals on 40 farms were enrolled in Germany (12 farms), the UK (10 farms), Italy (10 farms), and France (8 farms). Animals were selected based on pre-treatment faecal egg counts and were allocated to one of the two treatment groups. Each treatment group consisted of between 7 and 10 animals. A post-treatment faecal egg count was performed 14 days (±2 days) after treatment. The observed percentage reduction was calculated for each treatment group based on the arithmetic mean faecal egg count before and after treatment. The resistance status was evaluated based on the reduction in arithmetic mean faecal egg count and both the lower and upper 95% confidence limits. A decreased efficacy was observed in half or more of the farms in Germany, France and the UK. For moxidectin, resistance was confirmed on 3 farms in France, and on 1 farm in Germany and the UK. For ivermectin, resistance was confirmed on 3 farms in the UK, and on 1 farm in Germany and France. The remaining farms with decreased efficacy were classified as having an inconclusive resistance status based on the available data. After treatment Cooperia spp. larvae were most frequently identified, though Ostertagia ostertagi was also found, in particular within the UK and Germany. The present study reports lower than expected efficacy for ivermectin and moxidectin (based on the reduction in egg excretion after treatment) on European cattle farms, with confirmed anthelmintic resistance on 12.5% of the farms.

show abstract

Section: Discussionmentioning

confidence: 99%

Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe

Geurden

Chartier

Fanke

et al. 2015

International Journal for Parasitology: Drugs and Drug Resistan

133

View full text Add to dashboard Cite

show abstract

“…IVM and other macrocyclic lactones are currently the most commonly used anthelmintics in the UK sheep industry [16] and in the US cattle industry [17]. They are also the most frequently used anthelmintics to control equine roundworms in the UK 18, 19.…”

Section: Use In Veterinary and Human Medicinementioning

confidence: 99%

Ivermectin – Old Drug, New Tricks?

Laing

Gillan

Devaney

2017

Trends in Parasitology

332

237

View full text Add to dashboard Cite

Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved. Here we discuss the history of this versatile drug and its use in global health. Based on recent studies in a variety of systems, we question whether ivermectin could have additional modes of action on parasitic nematodes.

show abstract

“…While anemia in livestock may be associated with nutritional deficiency (e.g., iron, copper, and vitamin E), anemia in domestic animals is primarily caused by infestation by nematode parasites. 1,2 The most common test for anemia diagnosis in livestock is blood hemoglobin (Hgb) content, which is typically included in a complete blood count (CBC). Laboratory testing can be used to screen for underlying diseases before clinical signs or loss of production are present.…”

Section: Introductionmentioning

confidence: 99%

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

et al. 2016

View full text Add to dashboard Cite

Abstract. Anemia associated with intestinal parasites and malnutrition is the leading cause of morbidity and mortality in small ruminants worldwide. Qualitative scoring of conjunctival redness has been developed so that farmers can gauge anemia in sheep and goats to identify animals that require treatment. For clinically relevant anemia diagnosis, complete blood count-comparable quantitative methods often rely on complicated and expensive optical instruments, requiring detailed spectral information of hemoglobin. We report experimental and numerical results for simple, yet reliable, noninvasive hemoglobin detection that can be correlated with laboratory-based blood hemoglobin testing for anemia diagnosis. In our pilot animal study using calves, we exploit the third eyelid (i.e., palpebral conjunctiva) as an effective sensing site. To further test spectrometerfree (or spectrometerless) hemoglobin assessments, we implement full spectral reconstruction from RGB data and partial least square regression. The unique combination of RGB-based spectral reconstruction and partial least square regression could potentially offer uncomplicated instrumentation and avoid the use of a spectrometer, which is vital for realizing a compact and inexpensive hematology device for quantitative anemia detection in the farm field.

show abstract

Herding the U.S. cattle industry toward a paradigm shift in parasite control

Cited by 43 publications

References 44 publications

Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe

Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe

Ivermectin – Old Drug, New Tricks?

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

Contact Info

Product

Resources

About