Herceptin-functionalized SK-BR-3 cell membrane-wrapped paclitaxel nanocrystals for enhancing the targeted therapy effect of HER2-positive breast cancer

Wu, Qian; Tong, Le; Zou, Zhiru; Li, Yingqiao; An, Jinyu; Shen, Wenwen; Gao, Yu; Liu, Ying; Wu, Chao

doi:10.1016/j.matdes.2022.110818

Cited by 8 publications

(1 citation statement)

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“…After being blocked for 1 h, the gel was incubated with primary antibody overnight at 4°C, and with secondary antibody for 1 h. Added developer, and the protein bands were photographed with an ultrasensitive chemiluminescence detector, and the grayscale values of each protein band were analyzed by ImageJ. [23][24][25]. Relative content (%) of each target protein was calculated according to the formula using GAPDH as the reference protein [26].…”

Section: Effect Of Strain 729 On Related Proteins In Hct116 Cellsmentioning

confidence: 99%

The Plant-Derived Lactic Acid Bacteria Increases the Cell Death of Human Colon Cancer Cell via Modulating the Apoptosis and Ferroptosis

Huang¹,

Wu²,

Li³

et al. 2023

Preprint

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Colon cancer is a common malignancy of digestive tract and has high incidence and mortality worldwide. As a normal flora in the human gastrointestinal tract, lactic acid bacteria have been proved to have health benefits, such as immune-regulation, anti-infection, and anti-tumor. In the present study, the inhibitory effects of 19 heat-inactivated plant-derived lactic acid bacteria on human colon cancer cell HCT116 were investigated. The results showed that heat-inactivated plant-derived lactic acid bacteria strain 729 had the strongest inhibitory effect on HCT116 cells among all tested bacteria. Treatment with heat-inactivated bacteria strain 729 could inhibit the proliferation of HCT-116 cells in dose-dependent manner, with 54.52% inhibition at a final concentration of 1×108 CFU/mL. Moreover, the heat-inactivated bacteria strain 729 could block the cell cycle, induce apoptosis, and promote cellular ferroptosis by downregulating the expression of GPX4 and xCT at protein level. According to the 16S rDNA sequencing, the plant-derived lactic acid bacteria strain 729 was Lactobacillus plantarum. Collectively, the results indicates that lactic acid bacteria strain 729 may be developed as special ingredients targeting colon cancer, but further in vivo studies are required.

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Section: Effect Of Strain 729 On Related Proteins In Hct116 Cellsmentioning

confidence: 99%