Herbs and the kidney

Bagnis, Corinne Isnard; Deray, Gilbert; Baumelou, A; Quintrec, Moglie Le; Vanherweghem, Jean Louis

doi:10.1053/j.ajkd.2004.02.009

Cited by 185 publications

(75 citation statements)

References 80 publications

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“…Commonly found adulterants include caffeine, indomethacin, acetaminophen, and steroids [7]. Heavy metals have also been identified in 10-15% of patented Asian medicines sold in California and have included lead, mercury, and arsenic [1]. These contaminations can seriously harm this patient population.…”

Section: Discussionmentioning

confidence: 99%

“…An estimated 75% of the world population, especially in developing countries, depend on botanical medicines for their healthcare [1]. In the western world, the popularity and consumption of herbal medicines have increased in the recent years.…”

Section: Introductionmentioning

confidence: 99%

“…The toxic effects of natural products usually involve either (1) direct toxicity of the substance, (2) misidentification of the plant, (3) product-drug and product-disease interactions, (4) drug alterations in the hemodynamics/function of the kidney, (5) electrolyte derangements, and (6) toxic effect of adulterants or contaminants of the herbal preparation [1]. …”

Section: Introductionmentioning

confidence: 99%

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Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Vamenta-Morris¹,

Shoemaker-Moyle²,

Abdel‐Rahman³

2014

Am J Nephrol

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Background: The use of complementary/alternative medicine has garnered rising interest in recent years. Natural products including herbs, vitamins, and minerals are the most popularly consumed. The Internet is a ubiquitous source of information/market for these supplements. Aim: To systematically evaluate the dietary and herbal supplement recommended for patients with CKD and ESRD on the Internet, and try to distinguish between the claim of the manufacturer and proven scientific data. Methods: A questionnaire assessing each website was formulated. Each product ingredient was recorded in the questionnaire by two independent reviewers and statistically analyzed. Results: Of the 184 websites, 28% claimed to decrease CKD progression, 60% did not advise to consult a doctor before taking the supplement, and >90% did not mention any potential drug interaction, disease interaction, or caution in use during pregnancy or in children. The ten common plant ingredients claiming to be beneficial in kidney diseases were uva ursi, dandelion, parsley, corn silk, juniper, celery, buchu, horsetail, marshmallow, and stinging nettle. In contrast to their claims, these substances were not adequately studied in humans. The available animal studies showed detrimental effects and potential drug interactions with commonly used medications in the CKD/ESRD population. Conclusions: Nephrologists need to be cognizant of the lack of substantiated proven benefits of these substances and of the potential adverse effects in the animal models that can translate to the patients. Most importantly, the policy needs to change regarding the regulation of these products to prevent patient harm and misinformation. i 2014 S. Karger AG, Basel

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Vamenta-Morris¹,

Shoemaker-Moyle²,

Abdel‐Rahman³

2014

Am J Nephrol

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“…[20][21][22] Additionally, some AA-containing herbs, such as Caulis Aristolochiae manshuriensis (CAM, Figure 1), reportedly induce similar ARF effects at high doses. 23,24 Some studies indicated that AA-induced nephrotoxicity is distinct from that induced by other toxicological substances, including heavy metals. 24 Furthermore, AA likely induces end-stage renal disease (ESRD) characterized by hyperhomocysteinemia in exposed patients.…”

Section: Introductionmentioning

confidence: 99%

“…23,24 Some studies indicated that AA-induced nephrotoxicity is distinct from that induced by other toxicological substances, including heavy metals. 24 Furthermore, AA likely induces end-stage renal disease (ESRD) characterized by hyperhomocysteinemia in exposed patients. [24][25][26] The nephrotoxicity of AA remains in dispute, and may occur through multiple mechanisms, such as direct cytotoxicity or oncogene activation and hypersensitivity, the latter of which can be confirmed by detecting AA-DNA adducts (7-(deoxyadenosin-N 6 -yl) aristolactam I or II) in renal biopsies.…”

Section: Introductionmentioning

confidence: 99%

Metabonomic Study of Aristolochic Acid-Induced Nephrotoxicity in Rats

et al. 2006

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This paper describes a metabonomic study characterizing the nephrotoxicity induced by aristolochic acid (AA), a suspected kidney toxicant. For these studies, we examined the biochemical compositions of AA-treated rat urine using LC-MS and pattern recognition methods. The biochemical and histological patterns of rat groups treated with different AA sources showed distinct differences from those of the control group. Certain metabolic pathways, such as homocysteine formation and the folate cycle were significantly accelerated, while others, including arachidonic acid biosynthesis, were decreased. A subset-validation procedure using linear discriminant analysis (LDA) and selected predictive variables indicated that approximately 95% of the treated and nontreated rat urine samples were classified correctly into their respective treatment groups. The results suggested that this metabonomic approach is a promising methodology for the rapid in vivo screening of nephrotoxicity associated with ingesting multi-ingredient medicinal herb supplements, and provides a valid method for comprehending the chemical-induced perturbations in the metabolic network and the networked lesions.

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Herbal Remedies and the Patient with Chronic Kidney Disease

Markell

2010

Herbal Supplements

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Herbs and the kidney

Cited by 185 publications

References 80 publications

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Internet Claims on Dietary and Herbal Supplements in Advanced Nephropathy: Truth or Myth

Metabonomic Study of Aristolochic Acid-Induced Nephrotoxicity in Rats

Herbal Remedies and the Patient with Chronic Kidney Disease

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