Herbosomes - Herbal Drug in Novel Drug Delivery System for the Management of Periodontal Disease

Abstract

The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compounds. Herbosomes are recently introduced herbal formulations that are better absorbed and as a result produce better bioavailability and actions than the conventional botanical extracts. Herbal excipients are non-toxic and compatible they have a major role to play in pharmaceutical formulation. Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared to modern medicines. However, phytotherapeutics needs a scientific approach to deliver the components in a sustained manner to increase patient's compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems for herbal constituents. Over the last decade, herbal and Ayurvedic drugs has become a subject of world importance, with both medicinal and economical implications. There are number of traditional herbal remedies for the treatment and management of diseases related to teeth, gum and oral hygiene. The aim of the present study is to present overall view of the current strategies adopted for the formulation and application of traditional herbal remedies. This review article summarizes the current data on the effect of natural products like Acacia catechu, Aloe vera, Chamomile, Azadirachata indica, and Glycyrriza glabra on management of various periodontal diseases together with their biological activities.

EFFECT OF ALOIN (ALOEVERA EXTRACT) ON THE LEVELS OF PORPHYROMONAS GINGIVALIS AND AGGREGATIBACTER ACTINOMYCETEMCOMITANS IN CHRONIC GENERALIZED PERIODONTITIS: A CLINICAL & MICROBIOLOGICAL STUDY

“…[1] Herbosomes are recently introduced herbal formulations that have better bioavailability, low toxicity and better theurapetic actions than the conventional botanical extracts. [7] Aloin, (10-glucopyranosyl-1,8-dihydroxy-3hydroxymethyl-9(10H)-anthracenone), an active compound obtained from Aloevera, which is known as miracle herb. Aloin when undergoes semi-synthetic modifications shows better antimicrobial activity than the unmodified one.…”

A Novel Targeted Drug Delivery Carrier: Herbosomes

“…The herbosome technique is noninvasive and passive. Herbosome components can be used in cosmetic and medicinal products and are nontoxic and nonmutagenic [20,21]. Hydrophilic solvent ethanol has now primarily replaced hazardous organic solvents such as tetrahydrofuran and dichloromethane, which are used in conventional procedures to generate herbosome complexes, enhancing their safety and potential for clinical applications.…”

“…Research has demonstrated the hepatoprotective properties of soy phospholipids, which work in concert to protect the liver from toxins, alcohol, and other medications. Additionally, they have been shown to raise plasma levels of circulating HDL and help with blood cholesterol clearance [20]. Phospholipids with a particular affinity for biological membranes include phosphatidylcholine.…”

Role of different polyherbal medicinal plants are used in the treatment of periodontitis disease

“…[3] There are several traditional herbal remedies used to treat and treat dental related conditions such as periodontitis as well as gingivitis. [4] This article attempts to use the best available evidence to demonstrate the scientific status of the subject and the need for further research to expand the current knowledge. [5] This overview presents various natural remedies that can help with periodontitis.…”