Herbosomes enhance the in vivo antioxidant activity and bioavailability of punicalagins from standardized pomegranate extract

Vora, Amisha; Londhe, Vaishali; Pandita, Nancy

doi:10.1016/j.jff.2014.12.017

Cited by 34 publications

(20 citation statements)

References 25 publications

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“…However, as previously shown in both rats and humans, the poor bioavailability of punicalagin represents a considerable limitation to pharmaceutical research on its potential therapeutic effects in vivo ( 24 ). The low bioavailability of ellagic acid generated from punicalagin is due to its hydrophilic structure and large molecular weight, which limits its absorption by simple diffusion, including oral administration ( 25 ). In addition, extremely low lipid solubility further restricts its permeability through the lipophilic layer of the gastrointestinal tract ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

2020

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Osteosarcoma is the most common primary malignant bone tumor among children and young people and is associated with poor prognosis. Punicalagin is an antioxidant ellagitannin found in pomegranate juice with known antiproliferation and anti-angiogenesis properties. However, the antitumor effect of punicalagin on osteosarcoma requires further investigation. In the present study, the inhibitory effect of punicalagin on proliferation and invasion was evaluated in one human osteoblast cell line (hFOB1.19) and three human osteosarcoma cell lines (U2OS, MG63 and SaOS2). The cancer cell apoptosis ratio was determined using flow cytometry. NF-κB signaling in these cells was also evaluated using western blotting analysis. A subcutaneous tumor xenograft model was initiated to study the efficacy of punicalagin on osteosarcoma development and angiogenesis in vivo . Punicalagin treatment significantly decreased osteosarcoma cell proliferation and increased apoptosis. In addition, the invasion potential of these cells in a transwell assay was also dramatically suppressed in osteosarcoma cells. Punicalagin not only induced the degradation of IκBα but also the nuclear translocation of p65, suggesting the attenuation of NF-κB signaling pathway following treatment. Moreover, punicalagin markedly downregulated interleukin (IL)-6 and IL-8 levels, which was consistent with the inhibition of NF-κB signaling. An NF-κB activator could reverse these effects. Using a tumor xenograft mouse model, it was demonstrated that punicalagin exposure inhibited osteosarcoma growth and angiogenesis in vivo . These observations confirmed the suppressive effect of punicalagin against osteosarcoma malignancies. The underlying molecular mechanisms may include inhibition of the NF-κB signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

2020

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“…[1][2][3] Phytosomes are a complex between natural water soluble phytoconstituents and natural phospholipids (like soy phospholipids) which are prepared by reaction of stoichiometric amounts of phospholipid and the phytoconstituents in a solvent to achieve lipid compatible molecular complexes and improve their absorption and bioavailability. 4,5 Phytosomes show more bioavailability as compared to conventional herbal extracts, because of the being much better absorbed (enhanced capacity to cross the lipoidal biomembrane) than liposomes, showing better bioavailability and reaching the systemic circulation. Therefore, phytosomes have been found superior benificial compared to the liposomes in delivery of herbal medicines and nutraceuticals as well as using in topical and skin care (cosmetic) products.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Rutin-loaded Nanophytosomes

Hooresfand¹,

Ghanbarzadeh²,

Hamishehkar³

2015

Pharm Sci

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“…was measured after 60 min (at room temperature) at 517 nm using ascorbic acid as standard. The higher DPPH free radical scavenging activity was correlated with lower absorbance of the reaction mixture 12 . The following formula was used to calculate percentage inhibition of DPPH, suggestive of percentage of scavenging activity of pigment on DPPH radicals:…”

Section: Evaluation Of Antioxidant Activity Of Pigmentsmentioning

confidence: 86%

Antibacterial Activity of Marine Bacterial Pigments Obtained from Arabian Sea Water Samples

Patel¹,

Dwivedi²,

Jadeja³

et al. 2020

J. Pure Appl. Microbiol.

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The Arabian Sea environment harbors numerous microorganisms that have developed unique metabolic abilities to ensure their survival in hostile habitats. The bacterial pigments are considered to be important metabolic product which is useful for bacteria and may exert specific biological properties including antibacterial activity. Moreover, there is an imperative need for exploring new antibacterial agents since; there are drug resistance issues with the existing antibiotics. Therefore, the present study was aimed to assess antibacterial activity of pigments extracted from marine bacteria of Arabian Sea water samples and to characterize the potent antibacterial pigment producing isolate. The water samples were obtained from Tithal (Valsad), Diu, Daman and Dandi beaches of India. Total 9 distinct pigmented bacteria were isolated. The pigments extracted from bacterial isolates were assessed for the antibacterial, antioxidant and anticancer activities. Four pigment producing isolates (NP5, NP6, NP8 & NP9) among the nine isolates showed good antibacterial activity against the different bacterial cultures. Among these four isolates, NP9 showed maximum antibacterial activity against all the test cultures. The pigment obtained from NP5 isolate exhibited higher antioxidant property as compared to NP6, NP8 and NP9. However, none of the pigments obtained from NP5, NP6 and NP9 exhibited anti-cancerous activity on MCF-7 cell line. The molecular identification by16srDNA sequencing revealed that NP9 belongs to Candidatus chryseobacterium massiliae (MK213063). Chryseobacterium has been known to produce yellow pigment; however, for the first time, the study suggests that Candidatus chryseobacterium massiliae strain produces red pigment with potent antibacterial activity. However, its antibacterial activity must be tested with more number of pathogens and study in disease animal model is needed to confirm the results of the study.

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Herbosomes enhance the in vivo antioxidant activity and bioavailability of punicalagins from standardized pomegranate extract

Cited by 34 publications

References 25 publications

Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

Punicalagin inhibited proliferation, invasion and angiogenesis of osteosarcoma through suppression of NF‑κB signaling

Preparation and Characterization of Rutin-loaded Nanophytosomes

Antibacterial Activity of Marine Bacterial Pigments Obtained from Arabian Sea Water Samples

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