Herbomineral Formulation's Safety and Efficacy Employed in Siddha System of Medicine: A Review

Devi, B Rama; Reddy, G. Dayanand; Kumar, G V Narasimha; Sathiyarajeswaran, P; Elankani, P

doi:10.7897/2230-8407.10014

Cited by 4 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A small dosage is suf icient for the metallic formulation to control the illness completely, it acts very fastly, single medicine has so many therapeutic values, it has signi icantly longer shelf life, older prepared medicines possess rich medicinal values, and geological variations will not occur in metallic drugs. (Thyagarajan, 2004;Devi et al, 2019). In this system, arsenic is called as Paasaanam.…”

Section: Introductionmentioning

confidence: 99%

Studies on Contributions of FTIR Spectroscopic analysis in the Puriৎication process of Veeram (Hg2Cl2) used in Siddha formulations

Madhavan¹,

Muthukumar²,

C³

et al. 2020

ijrps

View full text Add to dashboard Cite

In Siddha system Arsenics are called as Paasaanam (toxins). Veeram is one of the paasaanam, its chemical formula is Hg2Cl2 (Calomel). Internally arsenic based medicines are used for rheumatoid arthritis, generalized body pain, syphilis, epilepsy and cancer.Various organic agents are used to purify the veeram such as milk, tender coconut, bitter guard and lemon juice. In this study raw veeram and products obtained after purification were analyzed using FTIR Spectroscopy with a view to understand the need and mechanism of this purification processes. FTIR analysis was carried out before and after purification. Efforts were made to study various chemical changes veeram undergoes during this process. FTIR of the raw Veeram and its processed samples were recorded between 4000-400cm-1. In the study raw drug showed only nine functional groups in the region between 3789.36cm-1 and 468.75cm-1. Bitter gourd treated veeram peaks were observed in the region between 3526.99 and 476.62cm-1 and a total of 13-peaks were obtained. Milk treated veeram showed peaks in the region between 3851.10 and 470.39cm-1 and total of 16- peaks were obtained. This method indicated presence of large number of functional groups. Lemon juice treated veeram showed peaks in between 3839.33 and 471.99cm-1 total of 15-peaks were obtained. Tender coconut veeram peaks were observed in between 3877.84 and 477.33cm-1 and total of 15-peaks were obtained. From this data number of functional groups increased in purified samples which indicated that the toxic veeram is not only detoxified but also interacted with functional groups of purifying agents there by therapeutic potency is enhanced.

show abstract

Section: Introductionmentioning

confidence: 99%

Studies on Contributions of FTIR Spectroscopic analysis in the Puriৎication process of Veeram (Hg2Cl2) used in Siddha formulations

Madhavan¹,

Muthukumar²,

C³

et al. 2020

ijrps

View full text Add to dashboard Cite

show abstract

Traditional medicine for aging-related disorders: Implications for drug discovery

Banerjee

Pavane

Banu

et al. 2021

Stem Cells and Aging

View full text Add to dashboard Cite

Nano-formulation of herbo-mineral alternative medicine from linga chenduram and evaluation of antiviral efficacy

Al-Ansari

Singh²,

Al-Khattaf

et al. 2021

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Traditional medicine is becoming a primary source of health care in many countries in recent years. The current study proposes a new dimension of understanding a traditional origin treatment, using herbo-mineral preparations in nanoform. The herbo-mineral preparation , Linga chenduram [HMLC], was prepared according to the ancient palm script protocol dates back to 1000 years. In search of alternative therapy for the coronavirus, an attempt was made to determine this ethnic medicine formulation's therapeutic potential for viral hepatitis infection. The Hepatitis C virus [HCV] has several genomic similarities with SARS-CoV-2 viruses. The herbo-mineral formulation (HMLC) were analyzed using UV–vis, EDAX, FTIR, XRD, SEM, and TEM studies. SEM images confirmed the ' presence of nanoparticles with agglomerated conditions having an average grain size of 18 to 25 nm. EDAX studies showed the presence of metallic components in oxide or sulfide form in HMLC. The HCV inhibitory effects of HMLC indicated a good response. The cytotoxicity of this preparation against the Huh-7 human hepatoma cell line was significant. The HMLC showed a strong inhibitory effect on HCV replication in a dose-dependent manner. The genomic component of HCV is similar to COVID −19 virus. The Hepatitis C virus (HCV) NS3/4A protease has a striking three-dimensional structural similarity to the SARS-CoV2 M pro protease, particularly in the arrangement of key active site residues. So HMLC can be tried to treat coronavirus infection. At higher concentrations, HMLC exhibited over 100-fold inhibition. In the MTT assay, HMLC did not show any apparent cytotoxic effect on cell viability at the concentrations 1–100 µg. Histological studies indicated that the liver and kidney did not experience any toxicity by 7 and 15 consecutive days of administration of HMLC on experimental Wistar rats. Hence, the HMLC can be tried as a therapy for COVID −19 infections using the preparations strictly according to ethnopharmacological protocol and optimum doses.

show abstract

Herbomineral Formulation's Safety and Efficacy Employed in Siddha System of Medicine: A Review

Cited by 4 publications

References 4 publications

Studies on Contributions of FTIR Spectroscopic analysis in the Puriৎication process of Veeram (Hg2Cl2) used in Siddha formulations

Studies on Contributions of FTIR Spectroscopic analysis in the Puriৎication process of Veeram (Hg2Cl2) used in Siddha formulations

Traditional medicine for aging-related disorders: Implications for drug discovery

Nano-formulation of herbo-mineral alternative medicine from linga chenduram and evaluation of antiviral efficacy

Contact Info

Product

Resources

About