Herbicide/Pesticide Effects on Intestinal Epithelial Growth

Greenman, Stephanie B.; Rutten, Michael J.; Fowler, Wendy M.; Scheffler, Larry; Shortridge, Linda A.; Brown, Beth; Sheppard, Brett C.; Deveney, Karen E.; Deveney, Clifford W.; Trunkey, Donald D.

doi:10.1006/enrs.1997.3766

Cited by 32 publications

(25 citation statements)

References 48 publications

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“…Similarly, desquamation, haemorrhage and necrosis of the epithelial cells of the stomach and intestine were noticed post α-cypermethrin insecticide oral administration in rats . In vitro study showed that the cultured intestinal and colonic cell proliferation was decreased by diazinon insecticide (Greenman et al, 1997). In contrary of the present results, Zaleska-Freljan et al (1983) reported that promfenvinphos organophosphate pesticide induced no changes in the stomach, small and large intestine of mice.…”

Section: Discussioncontrasting

confidence: 91%

Effects of exposure to Diazinon on the lung and small intestine of Guinea pig, histological and some histochemical changes

Rady

2009

Braz. arch. biol. technol.

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Section: Discussioncontrasting

confidence: 91%

Effects of exposure to Diazinon on the lung and small intestine of Guinea pig, histological and some histochemical changes

Rady

2009

Braz. arch. biol. technol.

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“…Many chemicals, both natural and synthetic, can evidently possess estrogenic-like activities and interfere with female reproductive patterns [12]. These estrogenic chemicals have adverse effects not only in the reproductive system but also in the central nervous system during development and throughout life [14].…”

Section: Discussionmentioning

confidence: 99%

Effects and Neuro-toxic Mechanisms of 2,2',4,4',5,5'-Hexachlorobiphenyl and Endosulfan in Neuronal Stem Cells.

et al. 2001

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ABSTRACT. Endocrine disrupters are exogenous compounds thought to mimic the action of estrogen or other hormones and influence endocrine activity in the body (Juberg, 2000). These chemicals have adverse effects not only in the reproductive system but also in the central nervous system during development and throughout life. Polychlorinated biphenyls (PCBs) are a class of environmentally persistent and widespread halogenated hydrocarbons. It has been reported that PCBs are potential neurotoxicants. Endosulfan is an organochlorine insecticide that is extensively used to control pests in vegetables, cotton, and fruits. To determine the effect of 2, 2', 4, 4', 5, 5',-hexachlorobiphenyl(2, 4, 5-HCB) and endosulfan on embryo nervous system, we isolated neural stem cells from rat brain at embryonic day 17. Isolated neural stem cells showed pluripotenty. Stem cells could differentiate into neurons and glia. Neurite formation in endosulfan and 2, 4, 5-HCB treated cells. And it appeared to be decreased as compared with that in untreated cells. In order to know the neuro-toxic mechanisms of 2, 4, 5-HCB and endosulfan in neuronal stem cells, we investigated mitogen-activated protein kinase activity (MAPK) and gap junctional intercellular communication (GJIC). Endosulfan decreased the MAPK activity in dose dependent manner. Endosulfan and 2, 4, 5-HCB inhibited GJIC compared to the untreated cell by scrape loading dye transfer (SL/DT). 2, 4, 5-HCB and endosulfan decreased the expression of connexin 43 in dose dependent manner. These results indicated that 2, 4, 5-HCB and endosulfan may inhibit differentiation and proliferation of neural stem cells and gap junctional intercellular communication which play a crucial role in the maintenance of cellular homeostasis. KEY WORDS: endosulfan, gap junctional intercellular communication (GJIC), 2, 2', 4, 4', 5, 5',-hexachlorobiphenyl(2, 4, 5-HCB), mitogenactivated protein kinase (MAPK), neural stem cell.

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“…The other virulence traits tested were slime formation (Freeman et al 1989) and surface hydrophobicity (Rosenberg et al 1980, Scoaris et al 2008). Cytotoxicity of culture supernatant was examined on Hep-2 cells by incubating exponentially growing cells with the supernatant following the 3-(4, 5-dimethylthiazol-2-yl)2, 5-diphenyltetrazolium bromide (MTT) assay (Mosmann 1983, Greenman et al 1997.…”

Section: Diseased Fishmentioning

confidence: 99%

Isolation and characterization of virulent Aeromonas veronii from ascitic fluid of oscar Astronotus ocellatus showing signs of infectious dropsy

Sreedharan¹,

Philip²,

Singh³

2011

Dis. Aquat. Org.

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The cichlid oscar Astronotus ocellatus has worldwide commercial value in the pet fish industry because of its early maturation, relatively high fecundity, ability to identify its caretaker and also to alter colouration amongst conspecifics. Pathogenic strains of Aeromonas veronii resistant to multiple antibiotics were isolated from A. ocellatus individuals showing signs of infectious abdominal dropsy. The moribund fish showed haemorrhage in all internal organs, and pure cultures could be obtained from the abdominal fluid. The isolates recovered were biochemically identified as A. veronii biovar sobria and genetically confirmed as A. veronii based on 16S rRNA gene sequence analysis (GenBank accession no. FJ573179). The RAPD profile using 3 primers (OPA-3, OPA-4 and OPD-20) generated similar banding patterns for all isolates. They displayed cytotoxic and haemolytic activity and produced several exoenzymes which were responsible for the pathogenic potential of the isolates. In the representative isolate MCCB 137, virulence genes such as enterotoxin act, haemolytic toxin aerA, type 3 secretion genes such as aexT, ascV and ascF-ascG, and gcat (glycerophospholipidcholesterol acyltransferase) could be amplified. MCCB 137 exhibited a 50% lethal dose (LD 50 ) of 10 5.071 colony-forming units ml -1 in goldfish and could be subsequently recovered from lesions as well as from the internal organs. This is the first description of a virulent A. veronii from oscar. KEY WORDS: Aeromonas veronii · Oscar · Astronotus ocellatus · Virulence · Ornamental fishesResale or republication not permitted without written consent of the publisher

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Herbicide/Pesticide Effects on Intestinal Epithelial Growth

Cited by 32 publications

References 48 publications

Effects of exposure to Diazinon on the lung and small intestine of Guinea pig, histological and some histochemical changes

Effects of exposure to Diazinon on the lung and small intestine of Guinea pig, histological and some histochemical changes

Effects and Neuro-toxic Mechanisms of 2,2',4,4',5,5'-Hexachlorobiphenyl and Endosulfan in Neuronal Stem Cells.

Isolation and characterization of virulent Aeromonas veronii from ascitic fluid of oscar Astronotus ocellatus showing signs of infectious dropsy

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